TAK 779

Pricing Availability   Qty
Cat.No. 4340 - TAK 779 | C33H39N2O2.Cl | CAS No. 229005-80-5
Description: Potent and selective CCR5 and CCR2 chemokine receptor antagonist
Chemical Name: N-[[4-[[[6,7-Dihydro-2-(4-methylphenyl)-5H-benzocyclohepten-8-yl]carbonyl]amino]phenyl]methyl]tetrahydro-N,N-dimethyl-2H-pyran-4-aminium chloride
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (4)

Biological Activity for TAK 779

TAK 779 is a potent and selective CCR5 and CCR2 chemokine receptor antagonist (IC50 values = 1 nM and 27 nM, respectively). TAK 779 blocks the binding of macrophage inflammatory protein 1α and 1β to CHO cells (IC50 = 1 nM) and inhibits replication of R5 HIV-1 at 1.6-3.7 nM. In animal models, TAK 779 protects against ischemic brain injury and prevents development of asthma features.

Technical Data for TAK 779

M. Wt 531.13
Formula C33H39N2O2.Cl
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 229005-80-5
PubChem ID 183789
InChI Key VDALIBWXVQVFGZ-UHFFFAOYSA-N
Smiles CC1=CC=C(C2=CC(C=C(C(NC3=CC=C(C[N+](C)(C)C4CCOCC4)C=C3)=O)CCC5)=C5C=C2)C=C1.[Cl-]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for TAK 779

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 5.31 10
DMSO 2.66 5

Preparing Stock Solutions for TAK 779

The following data is based on the product molecular weight 531.13. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 18.83 mL 94.14 mL 188.28 mL
0.5 mM 3.77 mL 18.83 mL 37.66 mL
1 mM 1.88 mL 9.41 mL 18.83 mL
5 mM 0.38 mL 1.88 mL 3.77 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References for TAK 779

References are publications that support the biological activity of the product.

Baba et al (1999) A small-molecule, nonpeptide CCR5 antagonist with highly potent and selective anti-HIV-1 activity. Proc.Natl.Acad.Sci.U.S.A. 96 5698 PMID: 10318947

Suzaki et al (2008) A small-molecule compound targeting CCR5 and CXCR3 prevents airway hyperresponsiveness and inflammation. Eur.Respir.J. 31 783 PMID: 18094012

Takami et al (2002) TAK-779, a nonpeptide CC chemokine receptor antagonist, protects the brain against focal cerebral ischemia in mice. J.Cereb.Blood Flow Metab. 22 780 PMID: 12142563


If you know of a relevant reference for TAK 779, please let us know.

View Related Products by Product Action

View all Chemokine CC Receptor Antagonists

Keywords: TAK 779, TAK 779 supplier, TAK779, potent, selective, chemokines, receptors, antagonists, CCR5, CCR2, macrophage, viral, replication, ischemia, asthma, Chemokine, CC, Receptors, HIV, 4340, Tocris Bioscience

Citations for TAK 779

Citations are publications that use Tocris products.

Currently there are no citations for TAK 779. Do you know of a great paper that uses TAK 779 from Tocris? Please let us know.

Reviews for TAK 779

There are currently no reviews for this product. Be the first to review TAK 779 and earn rewards!

Have you used TAK 779?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


GPCR Product Listing

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling
Immunology Product Listing

Immunology Product Listing

A collection of over 190 products for immunology research, the guide includes research tools for the study of:

  • Chemokine and Cytokine Signaling
  • Chemotaxis
  • Complement System
  • Immune Cell Signaling
  • Inflammation
Asthma Poster

Asthma Poster

Asthma is one of the most common chronic diseases in the world, affecting over 300 million people. This poster highlights key pathways and new therapies used to treat the condition, including those currently in clinical development.

Rheumatoid Arthritis Poster

Rheumatoid Arthritis Poster

Rheumatoid arthritis (RA) is a chronic destructive inflammatory autoimmune disease that results from a breakdown in immune tolerance, for reasons that are as yet unknown. This poster summarizes the pathology of RA and the inflammatory processes involved, as well as describing some of the epigenetic modifications associated with the disease and the potential for targeting these changes in the discovery of new treatments.