GSK 2239633A

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Cat.No. 7071 - GSK 2239633A | C24H25ClN4O5S2 | CAS No. 1240516-71-5
Description: Potent CCR4 antagonist
Chemical Name: N-[[3-[[3-[[(5-Chloro-2-thienyl)sulfonyl]amino]-4-methoxy-1H-indazol-1-yl]methyl]phenyl]methyl]-2-hydroxy-2-methylpropanamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (4)

Biological Activity

Potent CCR4 antagonist (pIC50 = 7.83 in a 35S-GTPγS competition assay). Inhibits thymus activation-regulated chemokine (TARC) -induced F-actin polymerization in human whole blood.

Technical Data

M. Wt 549.06
Formula C24H25ClN4O5S2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1240516-71-5
PubChem ID 46861584
InChI Key YTEVTHHGQMUPHC-UHFFFAOYSA-N
Smiles COC1=C2C(NS(=O)(C3=CC=C(S3)Cl)=O)=NN(C2=CC=C1)CC4=CC(CNC(C(C)(O)C)=O)=CC=C4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 54.91 100

Preparing Stock Solutions

The following data is based on the product molecular weight 549.06. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.82 mL 9.11 mL 18.21 mL
5 mM 0.36 mL 1.82 mL 3.64 mL
10 mM 0.18 mL 0.91 mL 1.82 mL
50 mM 0.04 mL 0.18 mL 0.36 mL

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References

References are publications that support the biological activity of the product.

Procopiou et al (2012) Lead optimisation of the N1 substituent of a novel series of indazole arylsulfonamides as CCR4 antagonists and identification of a candidate for clinical investigation. Bioorg.Med.Chem.Lett. 22 2730 PMID: 22437117


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Keywords: GSK 2239633A, GSK 2239633A supplier, GSK2239633A, CCR4, antagonists, antagonism, potent, TARC, CCL17, thymus, activation-regulated, chemokines, CCL22, macrophage-derived, MDC, Chemokine, CC, Receptors, 7071, Tocris Bioscience

Citations for GSK 2239633A

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