UCB 35625

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Cat.No. 2757 - UCB 35625 | C30H37Cl2IN2O2 | CAS No. 202796-42-7
Description: Potent CCR1 and CCR3 antagonist
Chemical Name: 1,4-trans-1-(1-Cycloocten-1-ylmethyl)-4-[[(2,7-dichloro-9H-xanthen-9-yl)carbonyl]amino]-1-ethylpiperidinium iodide
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Literature (4)

Biological Activity

Potent chemokine CCR1 and CCR3 receptor antagonist. Inhibits MIP-1α-induced chemotaxis in CCR1 transfectants and eotaxin-induced chemotaxis in CCR3 transfectants (IC50 values are 9.57 and 93.8 nM respectively). Antagonizes CCR3-mediated entry of HIV-1 isolate 89.6 into NP-2 cells (IC50 = 57 nM).

Isomer also available.

Compound Libraries

UCB 35625 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 655.44
Formula C30H37Cl2IN2O2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 202796-42-7
PubChem ID 6918496
InChI Key FOAFBMYSXIGAOX-LQGGPMKRSA-N
Smiles ClC1=CC=C(OC(C=CC(Cl)=C3)=C3C2C(N[C@H]4CC[N@@+](C/C5=C/CCCCCC5)(CC)CC4)=O)C2=C1.ClC6=CC=C(OC(C=CC(Cl)=C8)=C8C7C(N[C@@H]9CC[N@+](C/C%10=C/CCCCCC%10)(CC)CC9)=O)C7=C6.[I-].[I-]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 65.54 100
ethanol 32.77 50

Preparing Stock Solutions

The following data is based on the product molecular weight 655.44. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.53 mL 7.63 mL 15.26 mL
5 mM 0.31 mL 1.53 mL 3.05 mL
10 mM 0.15 mL 0.76 mL 1.53 mL
50 mM 0.03 mL 0.15 mL 0.31 mL

Molarity Calculator

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Dilution Calculator

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Sabroe et al (2000) A small molecule antagonist of chemokine receptors CCR1 and CCR3. J.Biol.Chem. 275 25985 PMID: 10854442

Lopes de Mendonca et al (2005) Site-directed mutagenesis of CC chemokine receptor 1 reveals the mechanism of action of UCB 35625, a small molecule chemokine receptor antagonist. J.Biol.Chem. 280 4808 PMID: 15548526


If you know of a relevant reference for UCB 35625, please let us know.

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Keywords: UCB 35625, UCB 35625 supplier, Potent, CCR1, CCR3, antagonists, Chemokine, Receptors, UCB35625, Rantes, CC, 2757, Tocris Bioscience

1 Citation for UCB 35625

Citations are publications that use Tocris products. Selected citations for UCB 35625 include:

Liu et al (2016) Cancer-associated fibroblasts promote hepatocellular carcinoma metastasis through chemokine-activated hedgehog and TGF-β pathways. Cancer Lett. 379 49 PMID: 27216982


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Literature in this Area

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