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Biological Activity for UCB 35625
UCB 35625 is a potent chemokine CCR1 and CCR3 receptor antagonist. Inhibits MIP-1α-induced chemotaxis in CCR1 transfectants and eotaxin-induced chemotaxis in CCR3 transfectants (IC50 values are 9.57 and 93.8 nM respectively). Antagonizes CCR3-mediated entry of HIV-1 isolate 89.6 into NP-2 cells (IC50 = 57 nM).
Isomer also available.
Compound Libraries for UCB 35625
Technical Data for UCB 35625
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for UCB 35625
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for UCB 35625
The following data is based on the product molecular weight 655.44. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.53 mL||7.63 mL||15.26 mL|
|5 mM||0.31 mL||1.53 mL||3.05 mL|
|10 mM||0.15 mL||0.76 mL||1.53 mL|
|50 mM||0.03 mL||0.15 mL||0.31 mL|
References for UCB 35625
References are publications that support the biological activity of the product.
Sabroe et al (2000) A small molecule antagonist of chemokine receptors CCR1 and CCR3. J.Biol.Chem. 275 25985 PMID: 10854442
Lopes de Mendonca et al (2005) Site-directed mutagenesis of CC chemokine receptor 1 reveals the mechanism of action of UCB 35625, a small molecule chemokine receptor antagonist. J.Biol.Chem. 280 4808 PMID: 15548526
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Keywords: UCB 35625, UCB 35625 supplier, Potent, CCR1, CCR3, antagonists, Chemokine, Receptors, UCB35625, Rantes, CC, 2757, Tocris Bioscience
1 Citation for UCB 35625
Citations are publications that use Tocris products. Selected citations for UCB 35625 include:
Liu et al (2016) Cancer-associated fibroblasts promote hepatocellular carcinoma metastasis through chemokine-activated hedgehog and TGF-β pathways. Cancer Lett. 379 49 PMID: 27216982
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Literature in this Area
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