RS 102895 hydrochloride

Pricing Availability Delivery Time Qty
Cat.No. 2089 - RS 102895 hydrochloride | C21H21F3N2O2.HCl | CAS No. 1173022-16-6
Description: CCR2b chemokine receptor antagonist
Chemical Name: 1'-[2-[4-(Trifluoromethyl)phenyl]ethyl]-spiro[4H-3,1-benzoxazine-4,4'-piperidin]-2(1H)-one hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations (2)
Literature

Biological Activity

CCR2-selective chemokine receptor antagonist (IC50 values are 0.36 and 17.8 μM for inhibition of human recombinant CCR2b and CCR1 receptors respectively). Blocks MCP-1-stimulated calcium influx and chemotaxis with IC50 values of 32 nM and 1.7 μM respectively. Also inhibits α1A, α1D and 5-HT1A receptors.

Compound Libraries

RS 102895 hydrochloride is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 426.86
Formula C21H21F3N2O2.HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 1173022-16-6
PubChem ID 16759153
InChI Key KRRISOFSWVKYBF-UHFFFAOYSA-N
Smiles Cl.FC(F)(F)C1=CC=C(CCN2CCC3(CC2)OC(=O)NC2=CC=CC=C32)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 32.01 75

Preparing Stock Solutions

The following data is based on the product molecular weight 426.86. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.34 mL 11.71 mL 23.43 mL
5 mM 0.47 mL 2.34 mL 4.69 mL
10 mM 0.23 mL 1.17 mL 2.34 mL
50 mM 0.05 mL 0.23 mL 0.47 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Clark et al (1983) Synthesis and antihypertensive activity of 4'-substituted spiro[4H-3,1-benzoxazine-4,4'piperidin]-2(1H)-ones. J.Med.Chem. 26 657 PMID: 6842505

Mirzadegan et al (2000) Identification of the binding site for a novel class of CCR2b chemokine receptor antagonists. J.Biol.Chem. 275 25562 PMID: 10770925


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Keywords: CCR2b chemokine receptor antagonists Chemokine Receptors RS102895 hydrochloride Chemokine CC Receptors

2 Citations for RS 102895 hydrochloride

Citations are publications that use Tocris products. Selected citations for RS 102895 hydrochloride include:

Maxwell et al (2014) Tumor-derived CXCL8 signaling augments stroma-derived CCL2-promoted proliferation and CXCL12-mediated invasion of PTEN-deficient prostate cancer cells. Oncotarget 5 4895 PMID: 24970800

Sennlaub et al (2013) CCR2(+) monocytes infiltrate atrophic lesions in age-related macular disease and mediate photoreceptor degeneration in experimental subretinal inflammation in Cx3cr1 deficient mice. EMBO Mol Med 5 1775 PMID: 24142887


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