SB 328437

Pricing Availability Delivery Time Qty
Cat.No. 3650 - SB 328437 | C21H18N2O5 | CAS No. 247580-43-4
Description: Potent and selective CCR3 antagonist
Chemical Name: N-(1-Naphthalenylcarbonyl)-4-nitro-L-phenylalanine methyl ester
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Potent and selective CCR3 antagonist (IC50 = 4 nM). Displays > 2500-fold selectivity over C5aR, LTD4, CCR7, CXCR1 and CXCR2 receptors. Inhibits eotaxin-, eotaxin-2- and MCP-4-induced Ca2+ mobilization (IC50 values are 38, 35 and 20 nM respectively) and inhibits eotaxin-, eotaxin-2- and MCP-4-induced eosinophil chemotaxis with similar potencies.

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Technical Data

M. Wt 378.38
Formula C21H18N2O5
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 247580-43-4
PubChem ID 10474776
InChI Key VMFGCGRAIBLAFY-IBGZPJMESA-N
Smiles O=C(C2=CC=CC3=C2C=CC=C3)N[C@H](C(OC)=O)CC1=CC=C([N+]([O-])=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 37.84 100

Preparing Stock Solutions

The following data is based on the product molecular weight 378.38. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.64 mL 13.21 mL 26.43 mL
5 mM 0.53 mL 2.64 mL 5.29 mL
10 mM 0.26 mL 1.32 mL 2.64 mL
50 mM 0.05 mL 0.26 mL 0.53 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

White et al (2000) Identification of potent, selective non-peptide CC chemokine receptor-3 antagonist that inhibits eotaxin-, eotaxin-2-, and monocyte chemotactic protein-4-induced eosinophil migration. J.Biol.Chem. 275 36626 PMID: 10969084

Mori et al (2007) Selective suppression of Th2-mediated airway eosinophil infiltration by low-molecular weight CCR3 antagonists. Int.Immunol. 19 913 PMID: 17804691

Abonyo et al (2005) Autoregulation of CCL26 synthesis and secretion in A549 cells: a possible mechanism by which alveolar epithelial cells modulate airway inflammation. Am.J.Physiol.Lung Cell.Mole.Physiol. 289 L478 PMID:


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