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Biological Activity for BI-6901
BI-6901 is a potent and selective CCR10 antagonist (IC50 = 1 - 25 nM). BI-6901 inhibits CCL27-dependent chemotaxis of Ba/F3 cells (IC50 = 1 nM) and reduces inflammation in a DNFB-stimulated animal model of contact hypersensitivity.
Technical Data for BI-6901
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for BI-6901
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for BI-6901
The following data is based on the product molecular weight 453.56. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.2 mL||11.02 mL||22.05 mL|
|5 mM||0.44 mL||2.2 mL||4.41 mL|
|10 mM||0.22 mL||1.1 mL||2.2 mL|
|50 mM||0.04 mL||0.22 mL||0.44 mL|
References for BI-6901
References are publications that support the biological activity of the product.
Abeywardane et al (2016) N-Arylsulfonyl-a-amino carboxamides are potent and selective inhibitors of the chemokine receptor CCR10 that show efficacy in the murine DNFB model of contact hypersensitivity. Bioorg.Med.Chem.Lett. 26 5277 PMID: 27692854
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Citations for BI-6901
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Literature in this Area
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