You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
C 021 dihydrochloride
Potent CCR4 chemokine receptor antagonist (IC50 values are 0.14 and 0.039 μM for inhibition of chemotaxis in human and mouse respectively).
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 540.57. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.85 mL||9.25 mL||18.5 mL|
|5 mM||0.37 mL||1.85 mL||3.7 mL|
|10 mM||0.18 mL||0.92 mL||1.85 mL|
|50 mM||0.04 mL||0.18 mL||0.37 mL|
References are publications that support the biological activity of the product.
Yokoyama et al (2009) Potent and orally bioavailable CCR4 antagonists: synthesis and structure-activity relationship study of 2-aminoquinazolines. Bioorg.Med.Chem. 17 64 PMID: 19081254
If you know of a relevant reference for C 021 dihydrochloride, please let us know.
View Related Products by Product Action
Keywords: C 021 dihydrochloride, C 021 dihydrochloride supplier, C021, dihydrochloride, potent, CCR4, chemokines, receptors, antagonists, Chemokine, CC, Receptors, 3581, Tocris Bioscience
5 Citations for C 021 dihydrochloride
Citations are publications that use Tocris products. Selected citations for C 021 dihydrochloride include:
McMillin et al (2014) Neuronal CCL2 is upregulated during hepatic encephalopathy and contributes to microglia activation and neurological decline. J Neuroinflammation 11 121 PMID: 25012628
Rasheed et al (2018) CCL17/TARC and CCR4 expression in Merkel cell carcinoma. Oncotarget 9 31432 PMID: 30140381
He et al (2018) Circadian Expression of Migratory Factors Establishes Lineage-Specific Signatures that Guide the Homing of Leukocyte Subsets to Tissues. Immunity 49 1175 PMID: 30527911
Kwon et al (2015) CCL2 Mediates Neuron-Macrophage Interactions to Drive Proregenerative Macrophage Activation Following Preconditioning Injury. J Neurosci 35 15934 PMID: 26631474
Palchevskiy et al (2019) CCR4 expression on host T cells is a driver for alloreactive responses and lung rejection. JCI Insight 5 PMID: 31085832
Do you know of a great paper that uses C 021 dihydrochloride from Tocris? Please let us know.
Reviews for C 021 dihydrochloride
Average Rating: 1 (Based on 1 Review.)
Have you used C 021 dihydrochloride?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
I used it both in vivo and in vitro. In vitro, I was unable to find any impact in chemotaxis towards CCL17
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Rheumatoid Arthritis Poster
Rheumatoid arthritis (RA) is a chronic destructive inflammatory autoimmune disease that results from a breakdown in immune tolerance, for reasons that are as yet unknown. This poster summarizes the pathology of RA and the inflammatory processes involved, as well as describing some of the epigenetic modifications associated with the disease and the potential for targeting these changes in the discovery of new treatments.