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C 021 dihydrochloride is a potent CCR4 chemokine receptor antagonist (IC50 values are 0.14 and 0.039 μM for inhibition of chemotaxis in human and mouse respectively).
C 021 dihydrochloride is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
The following data is based on the product molecular weight 540.57. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.85 mL||9.25 mL||18.5 mL|
|5 mM||0.37 mL||1.85 mL||3.7 mL|
|10 mM||0.18 mL||0.92 mL||1.85 mL|
|50 mM||0.04 mL||0.18 mL||0.37 mL|
References are publications that support the biological activity of the product.
Yokoyama et al (2009) Potent and orally bioavailable CCR4 antagonists: synthesis and structure-activity relationship study of 2-aminoquinazolines. Bioorg.Med.Chem. 17 64 PMID: 19081254
If you know of a relevant reference for C 021 dihydrochloride, please let us know.
Keywords: C 021 dihydrochloride, C 021 dihydrochloride supplier, C021, dihydrochloride, potent, CCR4, chemokines, receptors, antagonists, Chemokine, CC, Receptors, 3581, Tocris Bioscience
Citations are publications that use Tocris products. Selected citations for C 021 dihydrochloride include:
He et al (2018) Circadian Expression of Migratory Factors Establishes Lineage-Specific Signatures that Guide the Homing of Leukocyte Subsets to Tissues. Immunity 49 1175 PMID: 30527911
Palchevskiy et al (2019) CCR4 expression on host T cells is a driver for alloreactive responses and lung rejection. JCI Insight 5 PMID: 31085832
McMillin et al (2014) Neuronal CCL2 is upregulated during hepatic encephalopathy and contributes to microglia activation and neurological decline. J Neuroinflammation 11 121 PMID: 25012628
Kwon et al (2015) CCL2 Mediates Neuron-Macrophage Interactions to Drive Proregenerative Macrophage Activation Following Preconditioning Injury. J Neurosci 35 15934 PMID: 26631474
Rasheed et al (2018) CCL17/TARC and CCR4 expression in Merkel cell carcinoma. Oncotarget 9 31432 PMID: 30140381
Do you know of a great paper that uses C 021 dihydrochloride from Tocris? Please let us know.
Average Rating: 1 (Based on 1 Review.)
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I used it both in vivo and in vitro. In vitro, I was unable to find any impact in chemotaxis towards CCL17
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Rheumatoid arthritis (RA) is a chronic destructive inflammatory autoimmune disease that results from a breakdown in immune tolerance, for reasons that are as yet unknown. This poster summarizes the pathology of RA and the inflammatory processes involved, as well as describing some of the epigenetic modifications associated with the disease and the potential for targeting these changes in the discovery of new treatments.