C 021 dihydrochloride

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Cat.No. 3581 - C 021 dihydrochloride | C27H41N5O2.2HCl | CAS No. 1784252-84-1
Description: Potent CCR4 antagonist
Chemical Name: 2-[1,4'-Bipiperidin]-1'-yl-N-cycloheptyl-6,7-dimethoxy-4-quinazolinamine dihydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations (5)
Reviews (1)
Literature (4)

Biological Activity

Potent CCR4 chemokine receptor antagonist (IC50 values are 0.14 and 0.039 μM for inhibition of chemotaxis in human and mouse respectively).

Compound Libraries

C 021 dihydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 540.57
Formula C27H41N5O2.2HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 1784252-84-1
PubChem ID 56972238
InChI Key GKJKNYQUFAPLOQ-UHFFFAOYSA-N
Smiles COC1=C(OC)C=C(N=C(N4CCC(N5CCCCC5)CC4)N=C2NC3CCCCCC3)C2=C1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 26.96 50
DMSO 53.93 100

Preparing Stock Solutions

The following data is based on the product molecular weight 540.57. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.85 mL 9.25 mL 18.5 mL
5 mM 0.37 mL 1.85 mL 3.7 mL
10 mM 0.18 mL 0.92 mL 1.85 mL
50 mM 0.04 mL 0.18 mL 0.37 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Yokoyama et al (2009) Potent and orally bioavailable CCR4 antagonists: synthesis and structure-activity relationship study of 2-aminoquinazolines. Bioorg.Med.Chem. 17 64 PMID: 19081254


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Keywords: C 021 dihydrochloride, C 021 dihydrochloride supplier, C021, dihydrochloride, potent, CCR4, chemokines, receptors, antagonists, Chemokine, CC, Receptors, 3581, Tocris Bioscience

5 Citations for C 021 dihydrochloride

Citations are publications that use Tocris products. Selected citations for C 021 dihydrochloride include:

McMillin et al (2014) Neuronal CCL2 is upregulated during hepatic encephalopathy and contributes to microglia activation and neurological decline. J Neuroinflammation 11 121 PMID: 25012628

Rasheed et al (2018) CCL17/TARC and CCR4 expression in Merkel cell carcinoma. Oncotarget 9 31432 PMID: 30140381

He et al (2018) Circadian Expression of Migratory Factors Establishes Lineage-Specific Signatures that Guide the Homing of Leukocyte Subsets to Tissues. Immunity 49 1175 PMID: 30527911

Kwon et al (2015) CCL2 Mediates Neuron-Macrophage Interactions to Drive Proregenerative Macrophage Activation Following Preconditioning Injury. J Neurosci 35 15934 PMID: 26631474


Do you know of a great paper that uses C 021 dihydrochloride from Tocris? Please let us know.

Reviews for C 021 dihydrochloride

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Unfortunately I found no effect..
By Anonymous on 12/12/2017
Species: Human

I used it both in vivo and in vitro. In vitro, I was unable to find any impact in chemotaxis towards CCL17


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