You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
INCB 3284 dimesylate
Biological Activity for INCB 3284 dimesylate
INCB 3284 dimesylate is a potent, selective hCCR2 antagonist. Exhibits potent antagonism against monocyte chemoattractant molecule binding to hCCR2 and chemotaxis activity (IC50 values are 3.7 and 4.7 nM respectively). Also displays weak hERG activity; inhibits the hERG potassium current (IC50 = 84μM). Orally bioavailable.
Compound Libraries for INCB 3284 dimesylate
Technical Data for INCB 3284 dimesylate
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for INCB 3284 dimesylate
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for INCB 3284 dimesylate
The following data is based on the product molecular weight 712.76. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.4 mL||7.01 mL||14.03 mL|
|5 mM||0.28 mL||1.4 mL||2.81 mL|
|10 mM||0.14 mL||0.7 mL||1.4 mL|
|50 mM||0.03 mL||0.14 mL||0.28 mL|
Product Datasheets for INCB 3284 dimesylate
References for INCB 3284 dimesylate
References are publications that support the biological activity of the product.
Xue et al (2011) Discovery of INCB3284, a potent, selective, and orally bioavailable hCCR2 antagonist. ACS.Med.Chem.Lett. 2 450
If you know of a relevant reference for INCB 3284 dimesylate, please let us know.
View Related Products by Product Action
Keywords: INCB 3284 dimesylate, INCB 3284 dimesylate supplier, INCB3284, CCR2, antagonist, antagonists, hCCR2, human, chemokine, receptor, receptors, Chemokine, CC, Receptors, 4306, Tocris Bioscience
3 Citations for INCB 3284 dimesylate
Citations are publications that use Tocris products. Selected citations for INCB 3284 dimesylate include:
Zhou et al (2015) Klotho gene deficiency causes salt-sensitive hypertension via monocyte chemotactic protein-1/CC chemokine receptor 2-mediated inflammation. Nat Commun 26 121 PMID: 24904083
McMillin et al (2014) Neuronal CCL2 is upregulated during hepatic encephalopathy and contributes to microglia activation and neurological decline. J Neuroinflammation 11 121 PMID: 25012628
Liu et al (2016) Cancer-associated fibroblasts promote hepatocellular carcinoma metastasis through chemokine-activated hedgehog and TGF-β pathways. Cancer Lett. 379 49 PMID: 27216982
Do you know of a great paper that uses INCB 3284 dimesylate from Tocris? Please let us know.
Reviews for INCB 3284 dimesylate
There are currently no reviews for this product. Be the first to review INCB 3284 dimesylate and earn rewards!
Have you used INCB 3284 dimesylate?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Rheumatoid Arthritis Poster
Rheumatoid arthritis (RA) is a chronic destructive inflammatory autoimmune disease that results from a breakdown in immune tolerance, for reasons that are as yet unknown. This poster summarizes the pathology of RA and the inflammatory processes involved, as well as describing some of the epigenetic modifications associated with the disease and the potential for targeting these changes in the discovery of new treatments.