BMS CCR2 22

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Cat.No. 3129 - BMS CCR2 22 | C28H34F3N5O4S | CAS No. 445479-97-0
Description: High affinity, potent CCR2 antagonist
Chemical Name: 2-[(Isopropylaminocarbonyl)amino]-N-[2-[[cis-2-[[4-(methylthio)benzoyl]amino]cyclohexyl]amino]-2-oxoethyl]-5-(trifluoromethyl)benzamide
Purity: ≥98% (HPLC)
Datasheet
Citations (1)

Biological Activity

High affinity CCR2 chemokine receptor antagonist (IC50 = 5.1 nM). Displays potent functional antagonism, IC50 values are 1 and 18 nM for chemotaxis and antagonism of calcium flux respectively. Selective over CCR3.

Compound Libraries

BMS CCR2 22 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 593.66
Formula C28H34F3N5O4S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 445479-97-0
PubChem ID 24801690
InChI Key IBPXYDUJQWENPM-XZOQPEGZSA-N
Smiles O=C(N[C@@H]2CCCC[C@@H]2NC(CNC(C3=C(NC(NC(C)C)=O)C=CC(C(F)(F)F)=C3)=O)=O)C1=CC=C(SC)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 59.37 100
ethanol 5.94 10

Preparing Stock Solutions

The following data is based on the product molecular weight 593.66. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.68 mL 8.42 mL 16.84 mL
5 mM 0.34 mL 1.68 mL 3.37 mL
10 mM 0.17 mL 0.84 mL 1.68 mL
50 mM 0.03 mL 0.17 mL 0.34 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Cherney et al (2008) Discovery of disubstituted cyclohexanes as a new class of CC chemokine receptor 2 antagonists. J.Med.Chem. 51 721 PMID: 18232650

You et al (2010) CCR2 receptor ligands inhibit Cav3.2 T-type calcium channels. Mol.Pharmacol. 77 211 PMID: 19864434


If you know of a relevant reference for BMS CCR2 22, please let us know.

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Keywords: High affinity potent CCR2 antagonists Chemokine Receptors BMSCCR222 Chemokine CC Receptors

1 Citation for BMS CCR2 22

Citations are publications that use Tocris products. Selected citations for BMS CCR2 22 include:

Volpe et al (2012) CCR2 acts as scavenger for CCL2 during monocyte chemotaxis. PLoS One 7 e37208 PMID: 22615942


Do you know of a great paper that uses BMS CCR2 22 from Tocris? If so please let us know.

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Pathways for BMS CCR2 22

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