BMS CCR2 22
High affinity CCR2 chemokine receptor antagonist (IC50 = 5.1 nM). Displays potent functional antagonism, IC50 values are 1 and 18 nM for chemotaxis and antagonism of calcium flux respectively. Selective over CCR3.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 593.66. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.68 mL||8.42 mL||16.84 mL|
|5 mM||0.34 mL||1.68 mL||3.37 mL|
|10 mM||0.17 mL||0.84 mL||1.68 mL|
|50 mM||0.03 mL||0.17 mL||0.34 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Cherney et al (2008) Discovery of disubstituted cyclohexanes as a new class of CC chemokine receptor 2 antagonists. J.Med.Chem. 51 721 PMID: 18232650
You et al (2010) CCR2 receptor ligands inhibit Cav3.2 T-type calcium channels. Mol.Pharmacol. 77 211 PMID: 19864434
If you know of a relevant reference for BMS CCR2 22, please let us know.
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Keywords: High affinity potent CCR2 antagonists Chemokine Receptors BMSCCR222 Chemokine CC Receptors
1 Citation for BMS CCR2 22
Citations are publications that use Tocris products. Selected citations for BMS CCR2 22 include:
Volpe et al (2012) CCR2 acts as scavenger for CCL2 during monocyte chemotaxis. PLoS One 7 e37208 PMID: 22615942
Do you know of a great paper that uses BMS CCR2 22 from Tocris? If so please let us know.