BX 513 hydrochloride

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Cat.No. 2769 - BX 513 hydrochloride | C28H29ClN2O.HCl | CAS No. 1216540-18-9
Description: Selective CCR1 antagonist
Alternative Names: VUF 2274
Chemical Name: 4-(4-Chlorophenyl)-4-hydroxy-α,α-diphenyl-1-piperidinepentanenitrile hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Selective CCR1 receptor antagonist (Ki values are 0.04, > 10, > 10 and > 10 nM for CCR1, CCR5, CXCR2 and CXCR4 receptors respectively). Inhibits MIP-1α-induced intracellular calcium mobilization (IC50 = 2.5 μM). Also a full inverse agonist at US28, a  HCMV-encoded chemokine receptor.

Technical Data

M. Wt 481.46
Formula C28H29ClN2O.HCl
Storage Desiccate at +4°C
Purity ≥99% (HPLC)
CAS Number 1216540-18-9
PubChem ID 56972186
InChI Key SSZWNUGWOGONQJ-UHFFFAOYSA-N
Smiles ClC1=CC=C(C2(O)CCN(CCCC(C4=CC=CC=C4)(C#N)C3=CC=CC=C3)CC2)C=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 48.15 100
ethanol 24.07 50

Preparing Stock Solutions

The following data is based on the product molecular weight 481.46. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.08 mL 10.39 mL 20.77 mL
5 mM 0.42 mL 2.08 mL 4.15 mL
10 mM 0.21 mL 1.04 mL 2.08 mL
50 mM 0.04 mL 0.21 mL 0.42 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Hesselgesser et al (1998) Identification and characterisation of small molecule functional antagonists of the CCR1 chemokine receptor. J.Biol.Chem. 273 15687 PMID: 9624164

Ng et al (1999) Discovery of a novel non-peptide CCR1 receptor antagonists. J.Med.Chem. 42 4680 PMID: 10579830

Casarosa et al (2003) Identification of the first nonpeptidergic inverse agonist for a constitutively active viral-encoded G-protein-coupled receptor. J.Biol.Chem. 278 5172 PMID: 12456673


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