CB2 Receptors

The CB2 receptor, also known as the peripheral cannabinoid receptor, is a member of the cannabinoid receptor group of G-protein-coupled receptors that also includes CB1 and GPR55. CB2 receptors are located primarily in immune cells both within and outside the CNS.

Products
Background
Literature
Gene Data

Agonists

Cat No Product Name / Activity
2663 CB 65
High affinity, selective CB2 agonist
2678 GP 2a
Selective CB2 agonist
2374 GW 405833
Selective, high affinity CB2 receptor partial agonist
3088 HU 308
Potent and selective CB2 agonist
1341 JWH 015
Selective CB2 agonist
1343 JWH 133
Potent, selective CB2 agonist
1783 JWH 133 (in Tocrisolve™ 100)
Potent, selective CB2 agonist (in water-soluble emulsion)
2434 L-759,656
Highly selective CB2 agonist
2433 L-759,633
High affinity, selective CB2 agonist
5826 LEI 101 hydrochloride
Potent and selective CB2 partial agonist; orally biovailable
4205 MDA 19
CB2 agonist
3556 SER 601
Potent, selective CB2 agonist

Antagonists

Cat No Product Name / Activity
1120 AM 630
CB2 selective antagonist/inverse agonist
4756 COR 170
Selective CB2 receptor inverse agonist
2479 JTE 907
Selective CB2 receptor antagonist/inverse agonist
5039 SR 144528
High affinity and selective CB2 inverse agonist

Other

Cat No Product Name / Activity
2764 GP 1a
Highly selective CB2 agonist

The CB2 receptor, also known as the peripheral cannabinoid receptor, is a member of the cannabinoid receptor group of G-protein-coupled receptors that also includes CB1 and GPR55. CB2 receptors are located primarily in immune cells both within and outside the central nervous system. The function of these receptors includes modulation of cytokine release and immune cell migration. In the brain CB2 receptors are expressed by microglia, blood vessels and some neurons.

External sources of pharmacological information for CB2 Receptors :

Literature for CB2 Receptors

GPCR

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Secretin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling
Neurodegeneration

Neurodegeneration Product Guide

A collection of over 275 products for neurodegeneration research, the guide includes research tools for the study of:

  • Alzheimer's disease
  • Parkinson's disease
  • Huntington's disease
Pain

Pain Research Product Guide

A collection of over 250 products for pain research, the guide includes research tools for the study of:

  • Nociception
  • Ion Channels
  • G-Protein-Coupled Receptors
  • Intracellular Signaling
Cannabinoid Receptor Ligands

Cannabinoid Receptor Ligands Scientific Review

Written by Roger Pertwee, this review discusses compounds which affect the activity of the endocannabinoid system, focusing particularly on ligands that are most widely used as experimental tools and denotes compounds available from Tocris.

CB2 Receptor Gene Data

Species Gene Symbol Gene Accession No. Protein Accession No.
Human CNR2 NM_001841 P34972
Mouse Cnr2 NM_009924 P47936
Rat Cnr2 NM_020543 Q9QZN9