CB 65

Pricing Availability   Qty
Description: High affinity, selective CB2 agonist
Chemical Name: N-Cyclohexyl-7-chloro-1-[2-(4-morpholinyl)ethyl]quinolin-4(1H)-one-3-carboxamide
Purity: ≥99% (HPLC)
Citations (1)
Literature (1)

Biological Activity for CB 65

CB 65 is a high affinity and selective CB2 receptor agonist; Ki values are 3.3 and > 1000 nM for CB2 and CB1 receptors respectively.

Technical Data for CB 65

M. Wt 417.93
Formula C22H28ClN3O3
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 913534-05-1
PubChem ID 16086891

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for CB 65

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 2.09 5 with gentle warming

Preparing Stock Solutions for CB 65

The following data is based on the product molecular weight 417.93. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.05 mM 47.85 mL 239.27 mL 478.55 mL
0.25 mM 9.57 mL 47.85 mL 95.71 mL
0.5 mM 4.79 mL 23.93 mL 47.85 mL
2.5 mM 0.96 mL 4.79 mL 9.57 mL

Molarity Calculator

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References for CB 65

References are publications that support the biological activity of the product.

Manera et al (2006) Design, synthesis, and biological evaluation of new 1,8-naphthyridin-4(1H)-on-3-carboxamide and quinolin-4(1H)-on-3-carboxamide derivatives as CB2 selective agonists. J.Med.Chem. 49 5947 PMID: 17004710

If you know of a relevant reference for CB 65, please let us know.

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Keywords: CB 65, CB 65 supplier, High, affinity, selective, CB2, agonists, cannabinoids, Receptors, CB65, cb2r, 2663, Tocris Bioscience

1 Citation for CB 65

Citations are publications that use Tocris products. Selected citations for CB 65 include:

Akoume et al (2019) A Differential Hypofunctionality of Gαi Proteins Occurs in Adolescent Idiopathic Scoliosis and Correlates with the Risk of Disease Progression. Sci Rep 9 10074 PMID: 31296888

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Cannabinoid Receptor Ligands Scientific Review

Cannabinoid Receptor Ligands Scientific Review

Written by Roger Pertwee, this review discusses compounds which affect the activity of the endocannabinoid system, focusing particularly on ligands that are most widely used as experimental tools and denotes compounds available from Tocris.