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CB 65 is a high affinity and selective CB2 receptor agonist; Ki values are 3.3 and > 1000 nM for CB2 and CB1 receptors respectively.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|DMSO||2.09||5 with gentle warming|
The following data is based on the product molecular weight 417.93. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.05 mM||47.85 mL||239.27 mL||478.55 mL|
|0.25 mM||9.57 mL||47.85 mL||95.71 mL|
|0.5 mM||4.79 mL||23.93 mL||47.85 mL|
|2.5 mM||0.96 mL||4.79 mL||9.57 mL|
References are publications that support the biological activity of the product.
Manera et al (2006) Design, synthesis, and biological evaluation of new 1,8-naphthyridin-4(1H)-on-3-carboxamide and quinolin-4(1H)-on-3-carboxamide derivatives as CB2 selective agonists. J.Med.Chem. 49 5947 PMID: 17004710
If you know of a relevant reference for CB 65, please let us know.
Keywords: CB 65, CB 65 supplier, High, affinity, selective, CB2, agonists, cannabinoids, Receptors, CB65, cb2r, 2663, Tocris Bioscience
Citations are publications that use Tocris products. Selected citations for CB 65 include:
Akoume et al (2019) A Differential Hypofunctionality of Gαi Proteins Occurs in Adolescent Idiopathic Scoliosis and Correlates with the Risk of Disease Progression. Sci Rep 9 10074 PMID: 31296888
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Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Epilepsy is a brain disease that affects 60 million people globally. More than 20 anti-seizure drugs are currently available, but these do not address the underlying causes of the condition. This poster summarizes current knowledge about the development of the condition and highlights some approaches that have disease-modifying effects in proof-of-concept studies.