JTE 907

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Cat.No. 2479 - JTE 907 | C24H26N2O6 | CAS No. 282089-49-0
Description: Selective CB2 receptor inverse agonist
Chemical Name: N-(1,3-Benzodioxol-5-ylmethyl)-1,2-dihydro-7-methoxy-2-oxo-8-(pentyloxy)-3-quinolinecarboxamide
Purity: ≥99% (HPLC)
Datasheet
Citations (9)
Reviews (1)
Literature (5)

Biological Activity

Highly selective cannabinoid CB2 receptor inverse agonist. Binds with high affinity to rat, mouse and human CB2 receptors (Ki values are 0.38, 1.55 and 35.9 nM respectively). Produces anti-inflammatory effects in vivo.

Compound Libraries

JTE 907 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 438.48
Formula C24H26N2O6
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 282089-49-0
PubChem ID 9867770
InChI Key GRAJFFFXJYFVOC-UHFFFAOYSA-N
Smiles CCCCCOC1=C2NC(=O)C(=CC2=CC=C1OC)C(=O)NCC1=CC2=C(OCO2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 43.85 100
ethanol 4.38 10

Preparing Stock Solutions

The following data is based on the product molecular weight 438.48. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.28 mL 11.4 mL 22.81 mL
5 mM 0.46 mL 2.28 mL 4.56 mL
10 mM 0.23 mL 1.14 mL 2.28 mL
50 mM 0.05 mL 0.23 mL 0.46 mL

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References

References are publications that support the biological activity of the product.

Iwamura et al (2001) In vitro and in vivo pharmacological characterization of JTE-907, a novel selective ligand for cannabinoid CB2 receptor. J.Pharmacol.Exp.Ther. 296 420 PMID: 11160626

Ueda et al (2005) Involvement of cannabinoid CB2 receptor-mediated response and efficacy of cannabinoid CB2 receptor inverse agonist, JTE 907, in cutaneous inflammation in mice. Eur.J.Pharmacol. 520 164 PMID: 16153638

Maekawa et al (2006) The cannabinoid CB2 receptor inverse agonist JTE-907 suppresses spontaneous itch-associated responses of NC mice, a model of atopic dermatitis. Eur.J.Pharmacol. 542 179 PMID: 16824511


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Keywords: JTE 907, JTE 907 supplier, Selective, CB2, receptor, antagonists, inverse, agonists, cannabinoids, Receptors, JTE907, cb2r, 2479, Tocris Bioscience

9 Citations for JTE 907

Citations are publications that use Tocris products. Selected citations for JTE 907 include:

Wang et al (2016) Endothelial cation channel PIEZO1 controls blood pressure by mediating flow-induced ATP release. J Clin Invest 126 4527 PMID: 27797339

Price et al (2009) WIN55,212-2, a cannabinoid receptor agonist, protects against nigrostriatal cell loss in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease. Eur J Neurosci 29 2177 PMID: 19490092

Sánchez-Blázquez et al (2013) Cannabinoid receptors couple to NMDA receptors to reduce the production of NO and the mobilization of zinc induced by glutamate. Antioxid Redox Signal 19 1766 PMID: 23600761

Marini et al (2013) Characterization of cannabinoid receptor ligands in tissues natively expressing cannabinoid CB2 receptors. Br J Pharmacol 169 887 PMID: 23711022


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Reviews for JTE 907

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JTE 907 suppress skin inflammation.
By Anonymous on 02/04/2020
Assay Type: In Vivo
Species: Mouse

Orally administered JTE-907 (10 mg/kg) in a murine allergic contact dermatitis model.

Dissolved in DMSO

review image

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