JTE 907

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Description: Selective CB2 receptor inverse agonist
Chemical Name: N-(1,3-Benzodioxol-5-ylmethyl)-1,2-dihydro-7-methoxy-2-oxo-8-(pentyloxy)-3-quinolinecarboxamide
Purity: ≥99% (HPLC)
Datasheet
Citations (9)
Reviews (1)
Literature (1)

Biological Activity for JTE 907

JTE 907 is a highly selective cannabinoid CB2 receptor inverse agonist. Binds with high affinity to rat, mouse and human CB2 receptors (Ki values are 0.38, 1.55 and 35.9 nM respectively). Produces anti-inflammatory effects in vivo.

Technical Data for JTE 907

M. Wt 438.48
Formula C24H26N2O6
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 282089-49-0
PubChem ID 9867770
InChI Key GRAJFFFXJYFVOC-UHFFFAOYSA-N
Smiles CCCCCOC1=C2NC(=O)C(=CC2=CC=C1OC)C(=O)NCC1=CC2=C(OCO2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for JTE 907

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 43.85 100
ethanol 4.38 10

Preparing Stock Solutions for JTE 907

The following data is based on the product molecular weight 438.48. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.28 mL 11.4 mL 22.81 mL
5 mM 0.46 mL 2.28 mL 4.56 mL
10 mM 0.23 mL 1.14 mL 2.28 mL
50 mM 0.05 mL 0.23 mL 0.46 mL

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References for JTE 907

References are publications that support the biological activity of the product.

Iwamura et al (2001) In vitro and in vivo pharmacological characterization of JTE-907, a novel selective ligand for cannabinoid CB2 receptor. J.Pharmacol.Exp.Ther. 296 420 PMID: 11160626

Ueda et al (2005) Involvement of cannabinoid CB2 receptor-mediated response and efficacy of cannabinoid CB2 receptor inverse agonist, JTE 907, in cutaneous inflammation in mice. Eur.J.Pharmacol. 520 164 PMID: 16153638

Maekawa et al (2006) The cannabinoid CB2 receptor inverse agonist JTE-907 suppresses spontaneous itch-associated responses of NC mice, a model of atopic dermatitis. Eur.J.Pharmacol. 542 179 PMID: 16824511


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Keywords: JTE 907, JTE 907 supplier, Selective, CB2, receptor, antagonists, inverse, agonists, cannabinoids, Receptors, JTE907, cb2r, 2479, Tocris Bioscience

9 Citations for JTE 907

Citations are publications that use Tocris products. Selected citations for JTE 907 include:

Kong et al (2016) Cannabinoid WIN-55,212-2 mesylate inhibits ADAMTS-4 activity in human osteoarthritic articular chondrocytes by inhibiting expression of syndecan-1. Mol Cell Neurosci 13 4569 PMID: 27082728

Zhou et al (2015) Regional effects of endocannabinoid, BDNF and FGF receptor signalling on neuroblast motility and guidance along the rostral migratory stream. Br J Pharmacol 64 32 PMID: 25481343

Tan and Cao (2018) Cannabinoid WIN-55,212-2 mesylate inhibits tumor necrosis factor-α-induced expression of nitric oxide synthase in dorsal root ganglion neurons. Int J Mol Med 42 919 PMID: 29786105

Sánchez-Blázquez et al (2013) Cannabinoid receptors couple to NMDA receptors to reduce the production of NO and the mobilization of zinc induced by glutamate. Antioxid Redox Signal 19 1766 PMID: 23600761


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Reviews for JTE 907

Average Rating: 5 (Based on 1 Review.)

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JTE 907 suppress skin inflammation.
By Anonymous on 02/04/2020
Assay Type: In Vivo
Species: Mouse

Orally administered JTE-907 (10 mg/kg) in a murine allergic contact dermatitis model.

Dissolved in DMSO

review image

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Cannabinoid Receptor Ligands Scientific Review

Cannabinoid Receptor Ligands Scientific Review

Written by Roger Pertwee, this review discusses compounds which affect the activity of the endocannabinoid system, focusing particularly on ligands that are most widely used as experimental tools and denotes compounds available from Tocris.