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Biological Activity for SCH 336
SCH 336 is a highly potent and selective CB2 receptor inverse agonist (Ki = 1.8 nM, EC50 = 2 nM). Displays 100-fold selectivity for CB2 receptors over CB1. Increases forskolin stimulated cAMP accumulation in CHO cells expressing human CB2 receptors. Inhibits leukocyte migration in a murine model of delayed-type hypersensitivity and inhibits antigen-induced lung eosinophilia in a mouse allergy model.
Compound Libraries for SCH 336
Technical Data for SCH 336
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for SCH 336
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for SCH 336
The following data is based on the product molecular weight 539.64. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.85 mL||9.27 mL||18.53 mL|
|5 mM||0.37 mL||1.85 mL||3.71 mL|
|10 mM||0.19 mL||0.93 mL||1.85 mL|
|50 mM||0.04 mL||0.19 mL||0.37 mL|
References for SCH 336
References are publications that support the biological activity of the product.
Lunn et al (2006) A novel cannabinoid peripheral cannabinoid receptor-selective inverse agonist blocks leukocyte recruitment in vivo. J.Pharmacol.Exp.Ther. 316 780 PMID: 16258021
If you know of a relevant reference for SCH 336, please let us know.
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Keywords: SCH 336, SCH 336 supplier, SCH336, potent, selective, cannabinoid, 2, receptor, CB2, inverse, agonists, Receptors, 5815, Tocris Bioscience
Citations for SCH 336
Citations are publications that use Tocris products.
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Reviews for SCH 336
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Epilepsy is a brain disease that affects 60 million people globally. More than 20 anti-seizure drugs are currently available, but these do not address the underlying causes of the condition. This poster summarizes current knowledge about the development of the condition and highlights some approaches that have disease-modifying effects in proof-of-concept studies.