HU 308

Pricing Availability   Qty
Description: Potent and selective CB2 agonist
Chemical Name: (1S,4S,5S)-4-[4-(1,1-Dimethylheptyl)-2,6-dimethoxyphenyl]-6,6-dimethylbicyclo[3.1.1]hept-2-ene-2-methanol
Purity: ≥98% (HPLC)
Datasheet
Citations (7)
Reviews
Literature (1)

Biological Activity for HU 308

HU 308 is a potent and selective CB2 receptor agonist (Ki values are 22.7 nM and > 10 μM for CB2 and CB1 receptors respectively, EC50 = 5.57 nM). Displays antiallodynic activity in the rat hindpaw incision model of postoperative pain. Also neuroprotective and improves motor performance in a mouse model of Huntington's Disease.

Technical Data for HU 308

M. Wt 414.62
Formula C27H42O3
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 256934-39-1
PubChem ID 11553430
InChI Key CFMRIVODIXTERW-BDTNDASRSA-N
Smiles CCCCCCC(C)(C)C1=CC(OC)=C([C@]2([H])[C@H](C3)C(C)(C)[C@H]3C(CO)=C2)C(OC)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for HU 308

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 41.46 100
ethanol 41.46 100

Preparing Stock Solutions for HU 308

The following data is based on the product molecular weight 414.62. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.41 mL 12.06 mL 24.12 mL
5 mM 0.48 mL 2.41 mL 4.82 mL
10 mM 0.24 mL 1.21 mL 2.41 mL
50 mM 0.05 mL 0.24 mL 0.48 mL

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Product Datasheets for HU 308

Certificate of Analysis / Product Datasheet
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References for HU 308

References are publications that support the biological activity of the product.

LaBuda et al (2005) Cannabinoid CB2 receptor agonist activity in the hindpaw incision model of postoperative pain. Eur.J.Pharmacol. 527 172 PMID: 16316653

Hanus et al (1999) HU-308: a specific agonist for CB2, a peripheral cannabinoid receptor. Proc.Natl.Acad.Sci.USA 96 14228 PMID: 10588688

Palazuelos et al (2009) Microglial CB2 cannabinoid receptors are neuroprotective in Huntington's disease excitotoxicity. Brain 132 3152 PMID: 19805493


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Keywords: HU 308, HU 308 supplier, Potent, selective, CB2, agonists, cannabinoids, Receptors, HU308, cb2r, huntingtons, disease, 3088, Tocris Bioscience

7 Citations for HU 308

Citations are publications that use Tocris products. Selected citations for HU 308 include:

Gianella-Borradori et al (2015) Ligand-based virtual screening identifies a family of selective cannabinoid receptor 2 agonists. Bioorg Med Chem 23 241 PMID: 25487422

Sardinha et al (2014) Experimental cannabinoid 2 receptor-mediated immune modulation in sepsis. Pharmacol Res Perspect 2014 978678 PMID: 24803745

Solbrig et al (2013) Prospects for cannabinoid therapies in viral encephalitis. Proc Natl Acad Sci U S A 1537 273 PMID: 24021420

Sheng et al (2019) Antiallodynic Effects of Cannabinoid Receptor 2 (CB2R) Agonists on Retrovirus Infection-Induced Neuropathic Pain. Pain Res Manag 2019 1260353 PMID: 31354896


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Reviews for HU 308

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Cannabinoid Receptor Ligands Scientific Review

Cannabinoid Receptor Ligands Scientific Review

Written by Roger Pertwee, this review discusses compounds which affect the activity of the endocannabinoid system, focusing particularly on ligands that are most widely used as experimental tools and denotes compounds available from Tocris.