CB1 Receptors

The CB1 receptor, also known as the central cannabinoid receptor, is a member of the cannabinoid receptor group of G-protein-coupled receptors that also includes CB2 and GPR55. CB1 receptors are found mainly in the terminals of central and peripheral neurons.

Products
Background
Literature
Gene Data

Agonists

Cat No Product Name / Activity
1319 ACEA
Potent, highly selective CB1 agonist
1318 ACPA
Potent, selective CB1 agonist
1781 ACPA (in Tocrisolve™ 100)
Potent, selective CB1 agonist (in water-soluble emulsion)
1354 Arvanil
Potent CB1 and TRPV1 agonist. Also anandamide transport inhibitor
3500 (±)-CP 47497
Potent CB1 agonist
1485 DEA
Endogenous CB1 agonist
2139 Leelamine hydrochloride
CB1 agonist
1121 (R)-(+)-Methanandamide
Potent and selective CB1 agonist
1782 (R)-(+)-Methanandamide (in Tocrisolve™ 100)
Potent and selective CB1 agonist (in water-soluble emulsion)
1568 NADA
Endogenous CB1 agonist. Also vanilloid agonist and inhibitor of FAAH and AMT
1411 Noladin ether
Endogenous agonist for CB1 and GPR55
0878 Oleamide
CB1 receptor agonist
3744 RVD-Hpα
Selective CB1 agonist

Antagonists

Cat No Product Name / Activity
1117 AM 251
Potent CB1 antagonist; also GPR55 agonist
1115 AM 281
Potent, selective CB1 antagonist/inverse agonist
6193 AM 4113
Selective, high affinity CB1 antagonist
5443 AM 6545
High affinity and selective CB1 antagonist
4236 CP 945598 hydrochloride
CB1 receptor antagonist
3791 Hemopressin (human, mouse)
Selective CB1 inverse agonist
1764 Hemopressin (rat)
Selective CB1 inverse agonist
2387 LY 320135
Selective CB1 receptor antagonist/inverse agonist
4063 MJ 15
Potent and selective CB1 antagonist
3921 NIDA 41020
High affinity CB1 antagonist
3676 PF 514273
Potent and selective CB1 antagonist
4605 (±)-SLV 319
Potent and selective CB1 receptor antagonist
0923 SR 141716A
Selective CB1 receptor antagonist
4345 TC-C 14G
Potent, high affinity CB1 receptor inverse agonist

Modulators

Cat No Product Name / Activity
2957 Org 27569
Potent allosteric CB1 modulator
5321 PSNCBAM-1
CB1 receptor negative allosteric modulator

Other

Cat No Product Name / Activity
1655 O-2050
Putative CB1 silent antagonist; displays mixed activity at CB receptors
2540 Tocrifluor T1117
Fluorescent cannabinoid ligand; fluorescent form of AM 251 (Cat. No. 1117)

The CB1 receptor, also known as the central cannabinoid receptor, is a member of the cannabinoid receptor group of G-protein-coupled receptors that also includes CB2 and GPR55. CB1 receptors are found mainly in the terminals of central and peripheral neurons, where they usually mediate inhibition of neurotransmitter release. They can also be present on some non-neuronal cells, including immune cells.

External sources of pharmacological information for CB1 Receptors :

Literature for CB1 Receptors

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Cannabinoid Receptor Ligands

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CB1 Receptor Gene Data

Species Gene Symbol Gene Accession No. Protein Accession No.
Human CNR1 NM_033181 P21554
Mouse Cnr1 NM_007726 P47746
Rat Cnr1 NM_012784 P20272