CB1 Receptors
The CB1 receptor, also known as the central cannabinoid receptor, is a member of the cannabinoid receptor group of G-protein-coupled receptors that also includes CB2 and GPR55. CB1 receptors are found mainly in the terminals of central and peripheral neurons.
CB1 Receptor Agonists |
|
|---|---|
| Cat. No. | Product Name / Activity |
| 1319 | ACEA |
| Potent and highly selective CB1 agonist | |
| 0878 | Oleamide |
| CB1 agonist | |
| 3744 | RVD-Hpα |
| Selective CB1 agonist; also CB2 PAM | |
CB1 Receptor Inverse Agonists |
|
| Cat. No. | Product Name / Activity |
| 1115 | AM 281 |
| Potent and selective CB1 inverse agonist | |
| 3791 | Hemopressin (human, mouse) |
| Selective CB1 inverse agonist | |
| 1764 | Hemopressin (rat) |
| Selective CB1 inverse agonist | |
| 2387 | LY 320135 |
| Selective CB1 inverse agonist | |
| 0923 | SR 141716A |
| Selective CB1 inverse agonist | |
| 4345 | TC-C 14G |
| High affinity and potent CB1 inverse agonist | |
| 7131 | TM 38837 |
| Highly potent CB1 inverse agonist; peripherally restricted | |
CB1 Receptor Antagonists |
|
| Cat. No. | Product Name / Activity |
| 1117 | AM 251 |
| Potent CB1 antagonist; also GPR55 agonist | |
| 6193 | AM 4113 |
| High affinity and selective CB1 antagonist | |
| 5443 | AM 6545 |
| High affinity and selective CB1 antagonist | |
| 6763 | AVE 1625 |
| Potent and selective CB1 receptor antagonist | |
| 4236 | CP 945598 hydrochloride |
| CB1 antagonist | |
| 4063 | MJ 15 |
| Potent and selective CB1 antagonist | |
| 5746 | NESS 0327 |
| Ultra-high affinity and selective CB1 antagonist | |
| 3676 | PF 514273 |
| High affinity and selective CB1 antagonist | |
| 4605 | (±)-SLV 319 |
| High affinity and selective CB1 antagonist | |
CB1 Receptor Modulators |
|
| Cat. No. | Product Name / Activity |
| 2957 | Org 27569 |
| Potent allosteric modulator of CB1 receptors | |
| 5321 | PSNCBAM-1 |
| Negative allosteric modulator of CB1 receptors | |
Other |
|
| Cat. No. | Product Name / Activity |
| 1655 | O-2050 |
| Putative CB1 antagonist; displays mixed activity at CB receptors | |
| 2540 | Tocrifluor T1117 |
| Fluorescent cannabinoid ligand; fluorescent form of AM 251 (Cat. No. 1117) | |
The CB1 receptor, also known as the central cannabinoid receptor, is a member of the cannabinoid receptor group of G-protein-coupled receptors that also includes CB2 and GPR55. CB1 receptors are found mainly in the terminals of central and peripheral neurons, where they usually mediate inhibition of neurotransmitter release. They can also be present on some non-neuronal cells, including immune cells.
External sources of pharmacological information for CB1 Receptors :
Literature for CB1 Receptors
Tocris offers the following scientific literature for CB1 Receptors to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
GPCR Product Listing
A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:
- Rhodopsin-like Receptors
- Glutamate Receptors
- Frizzled Receptors
- GPCR Signaling
Neurodegeneration Product Guide
A collection of over 275 products for neurodegeneration research, the guide includes research tools for the study of:
- Alzheimer's disease
- Parkinson's disease
- Huntington's disease
Pain Research Product Guide
A collection of over 280 products for pain research, the guide includes research tools for the study of:
- Nociception
- Ion Channels
- G-Protein-Coupled Receptors
- Intracellular Signaling
Cannabinoid Receptor Ligands Scientific Review
Written by Roger Pertwee, this review discusses compounds which affect the activity of the endocannabinoid system, focusing particularly on ligands that are most widely used as experimental tools and denotes compounds available from Tocris.
Addiction Poster
The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.
Schizophrenia Poster
Schizophrenia is a debilitating psychiatric disorder that affects 1% of the worldwide population. This poster describes the neurobiology of Schizophrenia, as well as highlighting the genetic and environmental factors that play a fundamental role in the etiology of the disease. The current and emerging drug targets are also discussed.
Our Neurodegeneration guide highlights over 275 products for neurodegeneration research.
Request copyRequest PDF
Our Pain guide highlights over 280 products for Pain research.
Request copyRequest PDF
Our Cannabinoid review gives an overview of the pharmacological ligands used to study the cannabinoid CB1 and CB2 receptors.
Request copyRequest PDF
Written by Prof David Nutt, this poster summarizes the brain circuits and neurotransmitter systems that are affected by the main classes of addictive drugs.
Request copyDownload PDFWritten by Justin M. Saunders and Javier González-Maeso
Our Schizophrenia poster highlights the targets and pathways representing the most promising strategies to pursue for novel drug development.
Request copyDownload PDF