CB1 Receptors
The CB1 receptor, also known as the central cannabinoid receptor, is a member of the cannabinoid receptor group of G-protein-coupled receptors that also includes CB2 and GPR55. CB1 receptors are found mainly in the terminals of central and peripheral neurons.
Agonists |
|
|---|---|
| Cat No | Product Name / Activity |
| 1319 | ACEA |
| Potent, highly selective CB1 agonist | |
| 1318 | ACPA |
| Potent, selective CB1 agonist | |
| 1781 | ACPA (in Tocrisolve™ 100) |
| Potent, selective CB1 agonist (in water-soluble emulsion) | |
| 1354 | Arvanil |
| Potent CB1 and TRPV1 agonist. Also anandamide transport inhibitor | |
| 3500 | (±)-CP 47497 |
| Potent CB1 agonist | |
| 1485 | DEA |
| Endogenous CB1 agonist | |
| 2139 | Leelamine hydrochloride |
| CB1 agonist | |
| 1121 | (R)-(+)-Methanandamide |
| Potent and selective CB1 agonist | |
| 1782 | (R)-(+)-Methanandamide (in Tocrisolve™ 100) |
| Potent and selective CB1 agonist (in water-soluble emulsion) | |
| 1568 | NADA |
| Endogenous CB1 agonist. Also vanilloid agonist and inhibitor of FAAH and AMT | |
| 1411 | Noladin ether |
| Endogenous agonist for CB1 and GPR55 | |
| 0878 | Oleamide |
| CB1 receptor agonist | |
| 3744 | RVD-Hpα |
| Selective CB1 agonist | |
Antagonists |
|
| Cat No | Product Name / Activity |
| 1117 | AM 251 |
| Potent CB1 antagonist; also GPR55 agonist | |
| 1115 | AM 281 |
| Potent, selective CB1 antagonist/inverse agonist | |
| 6193 | AM 4113 |
| Selective, high affinity CB1 antagonist | |
| 5443 | AM 6545 |
| High affinity and selective CB1 antagonist | |
| 4236 | CP 945598 hydrochloride |
| CB1 receptor antagonist | |
| 3791 | Hemopressin (human, mouse) |
| Selective CB1 inverse agonist | |
| 1764 | Hemopressin (rat) |
| Selective CB1 inverse agonist | |
| 2387 | LY 320135 |
| Selective CB1 receptor antagonist/inverse agonist | |
| 4063 | MJ 15 |
| Potent and selective CB1 antagonist | |
| 3921 | NIDA 41020 |
| High affinity CB1 antagonist | |
| 3676 | PF 514273 |
| Potent and selective CB1 antagonist | |
| 4605 | (±)-SLV 319 |
| Potent and selective CB1 receptor antagonist | |
| 0923 | SR 141716A |
| Selective CB1 receptor antagonist | |
| 4345 | TC-C 14G |
| Potent, high affinity CB1 receptor inverse agonist | |
Modulators |
|
| Cat No | Product Name / Activity |
| 2957 | Org 27569 |
| Potent allosteric CB1 modulator | |
| 5321 | PSNCBAM-1 |
| CB1 receptor negative allosteric modulator | |
Other |
|
| Cat No | Product Name / Activity |
| 1655 | O-2050 |
| Putative CB1 silent antagonist; displays mixed activity at CB receptors | |
| 2540 | Tocrifluor T1117 |
| Fluorescent cannabinoid ligand; fluorescent form of AM 251 (Cat. No. 1117) | |
The CB1 receptor, also known as the central cannabinoid receptor, is a member of the cannabinoid receptor group of G-protein-coupled receptors that also includes CB2 and GPR55. CB1 receptors are found mainly in the terminals of central and peripheral neurons, where they usually mediate inhibition of neurotransmitter release. They can also be present on some non-neuronal cells, including immune cells.
External sources of pharmacological information for CB1 Receptors :
Literature for CB1 Receptors
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Our Cannabinoid review gives an overview of the pharmacological ligands used to study the cannabinoid CB1 and CB2 receptors.
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Written by Prof David Nutt, this poster summarizes the brain circuits and neurotransmitter systems that are affected by the main classes of addictive drugs.
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Our Schizophrenia poster higlights the targets and pathways representing the most promising strategies to pursue for novel drug development.
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