CB1 Receptors
The CB1 receptor, also known as the central cannabinoid receptor, is a member of the cannabinoid receptor group of G-protein-coupled receptors that also includes CB2 and GPR55. CB1 receptors are found mainly in the terminals of central and peripheral neurons.
Agonists |
|
|---|---|
| Cat No | Product Name / Activity |
| 1319 | ACEA |
| Potent and highly selective CB1 agonist | |
| 1318 | ACPA |
| Potent and selective CB1 agonist | |
| 1781 | ACPA (in Tocrisolve™ 100) |
| Potent and selective CB1 agonist; supplied in water-soluble emulsion | |
| 1354 | Arvanil |
| Potent CB1 agonist; also anandamide transport inhibitor and TRPV1 agonist | |
| 3500 | (±)-CP 47497 |
| Potent CB1 agonist | |
| 1485 | DEA |
| Endogenous CB1 agonist | |
| 2139 | Leelamine hydrochloride |
| CB1 agonist | |
| 1121 | (R)-(+)-Methanandamide |
| Potent and selective CB1 agonist | |
| 1782 | (R)-(+)-Methanandamide (in Tocrisolve™ 100) |
| Potent and selective CB1 agonist; supplied in water-soluble emulsion | |
| 1568 | NADA |
| Endogenous CB1 agonist; also vanilloid agonist and inhibitor of FAAH and AMT | |
| 1411 | Noladin ether |
| Endogenous agonist for CB1 and GPR55 | |
| 0878 | Oleamide |
| CB1 agonist | |
| 3744 | RVD-Hpα |
| Selective CB1 agonist | |
Inverse Agonists |
|
| Cat No | Product Name / Activity |
| 1115 | AM 281 |
| Potent and selective CB1 inverse agonist | |
| 3791 | Hemopressin (human, mouse) |
| Selective CB1 inverse agonist | |
| 1764 | Hemopressin (rat) |
| Selective CB1 inverse agonist | |
| 2387 | LY 320135 |
| Selective CB1 inverse agonist | |
| 0923 | SR 141716A |
| Selective CB1 inverse agonist | |
| 4345 | TC-C 14G |
| High affinity and potent CB1 inverse agonist | |
Antagonists |
|
| Cat No | Product Name / Activity |
| 1117 | AM 251 |
| Potent CB1 antagonist; also GPR55 agonist | |
| 6193 | AM 4113 |
| High affinity and selective CB1 antagonist | |
| 5443 | AM 6545 |
| High affinity and selective CB1 antagonist | |
| 4236 | CP 945598 hydrochloride |
| CB1 antagonist | |
| 4063 | MJ 15 |
| Potent and selective CB1 antagonist | |
| 3921 | NIDA 41020 |
| High affinity CB1 antagonist | |
| 3676 | PF 514273 |
| Potent and selective CB1 antagonist | |
| 4605 | (±)-SLV 319 |
| Potent and selective CB1 antagonist | |
Modulators |
|
| Cat No | Product Name / Activity |
| 2957 | Org 27569 |
| Potent allosteric modulator of CB1 receptors | |
| 5321 | PSNCBAM-1 |
| Negative allosteric modulator of CB1 receptors | |
Other |
|
| Cat No | Product Name / Activity |
| 1655 | O-2050 |
| Putative CB1 antagonist; displays mixed activity at CB receptors | |
| 2540 | Tocrifluor T1117 |
| Fluorescent cannabinoid ligand; fluorescent form of AM 251 (Cat. No. 1117) | |
The CB1 receptor, also known as the central cannabinoid receptor, is a member of the cannabinoid receptor group of G-protein-coupled receptors that also includes CB2 and GPR55. CB1 receptors are found mainly in the terminals of central and peripheral neurons, where they usually mediate inhibition of neurotransmitter release. They can also be present on some non-neuronal cells, including immune cells.
External sources of pharmacological information for CB1 Receptors :
Literature for CB1 Receptors
Tocris offers the following scientific literature for CB1 Receptors to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
GPCR Product Listing
A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:
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- Secretin-like Receptors
- Glutamate Receptors
- Frizzled Receptors
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Neurodegeneration Product Guide
A collection of over 275 products for neurodegeneration research, the guide includes research tools for the study of:
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Cannabinoid Receptor Ligands Scientific Review
Written by Roger Pertwee, this review discusses compounds which affect the activity of the endocannabinoid system, focusing particularly on ligands that are most widely used as experimental tools and denotes compounds available from Tocris.
Addiction Poster
The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.
Schizophrenia Poster
Schizophrenia is a debilitating psychiatric disorder that affects 1% of the worldwide population. This poster describes the neurobiology of Schizophrenia, as well as highlighting the genetic and environmental factors that play a fundamental role in the etiology of the disease. The current and emerging drug targets are also discussed.
Our Neurodegeneration guide highlights over 275 products for neurodegeneration research.
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Our Pain guide highlights over 280 products for Pain research.
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Our Cannabinoid review gives an overview of the pharmacological ligands used to study the cannabinoid CB1 and CB2 receptors.
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Written by Prof David Nutt, this poster summarizes the brain circuits and neurotransmitter systems that are affected by the main classes of addictive drugs.
Request copyDownload PDFWritten by Justin M. Saunders and Javier González-Maeso
Our Schizophrenia poster highlights the targets and pathways representing the most promising strategies to pursue for novel drug development.
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