CB1 Receptors
The CB1 receptor, also known as the central cannabinoid receptor, is a member of the cannabinoid receptor group of G-protein-coupled receptors that also includes CB2 and GPR55. CB1 receptors are found mainly in the terminals of central and peripheral neurons.
Agonists |
Cat. No. | Product Name / Activity |
|---|---|
| 1319 | ACEA |
| Potent and highly selective CB1 agonist | |
| 1354 | Arvanil |
| Potent CB1 agonist; also anandamide transport inhibitor and TRPV1 agonist | |
| 1485 | DEA |
| Endogenous CB1 agonist | |
| 2139 | Leelamine hydrochloride |
| CB1 agonist | |
| 1568 | NADA |
| Endogenous CB1 agonist; also vanilloid agonist and inhibitor of FAAH and AMT | |
| 1411 | Noladin ether |
| Endogenous agonist for CB1 and GPR55 | |
| 0878 | Oleamide |
| CB1 agonist | |
| 3744 | RVD-Hpα |
| Selective CB1 agonist; also CB2 PAM | |
Inverse Agonists |
Cat. No. | Product Name / Activity |
| 1115 | AM 281 |
| Potent and selective CB1 inverse agonist | |
| 3791 | Hemopressin (human, mouse) |
| Selective CB1 inverse agonist | |
| 1764 | Hemopressin (rat) |
| Selective CB1 inverse agonist | |
| 2387 | LY 320135 |
| Selective CB1 inverse agonist | |
| 0923 | SR 141716A |
| Selective CB1 inverse agonist | |
| 4345 | TC-C 14G |
| High affinity and potent CB1 inverse agonist | |
Antagonists |
Cat. No. | Product Name / Activity |
| 1117 | AM 251 |
| Potent CB1 antagonist; also GPR55 agonist | |
| 6193 | AM 4113 |
| High affinity and selective CB1 antagonist | |
| 5443 | AM 6545 |
| High affinity and selective CB1 antagonist | |
| 6763 | AVE 1625 |
| Potent and selective CB1 receptor antagonist | |
| 4236 | CP 945598 hydrochloride |
| CB1 antagonist | |
| 4063 | MJ 15 |
| Potent and selective CB1 antagonist | |
| 5746 | NESS 0327 |
| Ultra-high affinity and selective CB1 antagonist | |
| 3676 | PF 514273 |
| High affinity and selective CB1 antagonist | |
| 4605 | (±)-SLV 319 |
| High affinity and selective CB1 antagonist | |
Modulators |
Cat. No. | Product Name / Activity |
| 2957 | Org 27569 |
| Potent allosteric modulator of CB1 receptors | |
| 5321 | PSNCBAM-1 |
| Negative allosteric modulator of CB1 receptors | |
Other |
Cat. No. | Product Name / Activity |
| 1655 | O-2050 |
| Putative CB1 antagonist; displays mixed activity at CB receptors | |
| 2540 | Tocrifluor T1117 |
| Fluorescent cannabinoid ligand; fluorescent form of AM 251 (Cat. No. 1117) | |
The CB1 receptor, also known as the central cannabinoid receptor, is a member of the cannabinoid receptor group of G-protein-coupled receptors that also includes CB2 and GPR55. CB1 receptors are found mainly in the terminals of central and peripheral neurons, where they usually mediate inhibition of neurotransmitter release. They can also be present on some non-neuronal cells, including immune cells.
External sources of pharmacological information for CB1 Receptors :
Literature for CB1 Receptors
Tocris offers the following scientific literature for CB1 Receptors to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
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Cannabinoid Receptor Ligands Scientific Review
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Our Neurodegeneration guide highlights over 275 products for neurodegeneration research.
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Our Cannabinoid review gives an overview of the pharmacological ligands used to study the cannabinoid CB1 and CB2 receptors.
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Request copyDownload PDFWritten by Justin M. Saunders and Javier González-Maeso
Our Schizophrenia poster highlights the targets and pathways representing the most promising strategies to pursue for novel drug development.
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