CaV3.x Channels (T-type)

CaV3.x channels (T-type) are low-voltage activated channels with low single channel conductance. These channels are found in cells with rhythmic firing patterns where repetitive firing of action potentials is required. For example, they contribute the pacemaker potential of sinoatrial node cells in the heart, and also to the spontaneous spiking of neurons in the thalamus.

Products
Background
Literature
Gene Data

Activators

Cat No Product Name / Activity
6239 SAK 3
Potent CaV3.1 and 3.3 activator; orally bioavailable

Blockers

Cat No Product Name / Activity
4055 L-Ascorbic acid
Selective CaV3.2 blocker
3733 Efonidipine hydrochloride monoethanolate
CaV1.x and CaV3.x blocker
0522 Flunarizine dihydrochloride
Dual CaV3.x and NaV blocker
2198 Mibefradil dihydrochloride
CaV3.x blocker
4507 ML 218 hydrochloride
CaV3.x blocker
2268 NNC 55-0396 dihydrochloride
Highly selective CaV3.x blocker
6651 (2R/S)-6-PNG
CaV3.2 blocker; active in vivo
4665 ProTx I
CaV3.1 blocker; also inhibits NaV1.8 and KV2.1
6367 Z 944
CaV3.x blocker

CaV3.x channels (T-type) are low-voltage activated channels with low single channel conductance. They are named T-type for their transient opening, resulting from their rapid and complete inactivation at positive membrane potentials. These channels are thought to consist only of a CaV3.x α1-subunit, with no auxiliary subunits.

Due to their properties and channel kinetics, CaV3.x channels are found in cells with rhythmic firing patterns where repetitive firing of action potentials is required. For example, they contribute the pacemaker potential of sinoatrial node cells in the heart, and also to the spontaneous spiking of neurons in the thalamus.

External sources of pharmacological information for CaV3.x Channels (T-type) :

    Literature for CaV3.x Channels (T-type)

    Tocris offers the following scientific literature for CaV3.x Channels (T-type) to showcase our products. We invite you to request* or download your copy today!

    *Please note that Tocris will only send literature to established scientific business / institute addresses.


    Cardiovascular

    Cardiovascular Research Product Guide

    A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:

    • Hypertension
    • Thrombosis and Hemostasis
    • Atherosclerosis
    • Myocardial Infarction
    • Ischemia/Reperfusion Injury
    • Arrhythmias
    • Heart Failure
    Ion Channel

    Ion Channel Product Listing

    A collection of around 500 products for ion channel research, the listing includes research tools for the study of:

    • Ligand-gated ion channels
    • Voltage-gated ion channels
    • Other Ion Channels
    Neurotransmission

    Neurotransmission Product Guide

    A collection of over 250 products for neurotransmission research, the guide includes research tools for the study of:

    • Dopaminergic Transmission
    • Glutamatergic Transmission
    • Opioid Peptide Transmission
    • Serotonergic Transmission
    • Chemogenetics

    Voltage-gated Calcium Channel Gene Data

    Gene Species Gene Symbol Gene Accession No. Protein Accession No.
    Cav3.1 Human CACNA1G NM_018896 Q9Y5T3
    Mouse Cacna1g NM_009783 NP_033913
    Rat Cacna1g NM_031601 Q9JL92
    Cav3.2 Human CACNA1H NM_001005407 O95180
    Mouse Cacna1h NM_021415 O88427
    Rat Cacna1h NM_153814 Q9EQ60
    Cav3.3 Human CACNA1I NM_001003406 Q9ULU9
    Mouse Cacna1i NM_001044308 NP_001037773
    Rat Cacna1i NM_020084 Q9Z0Y8