SAK 3

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Cat.No. 6239 - SAK 3 | C20H23N3O4 | CAS No. 1256269-87-0
Description: Potent CaV3.1 and 3.3 activator; orally bioavailable
Chemical Name: Ethyl 8'-methyl-2',4-dioxo-2-(piperidin-1-yl)-2'H-spiro[cyclopent[2]ene-1,3'-imidazo[1,2-a]pyridine]-3-carboxylate
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (3)

Biological Activity

Potent CaV3.1 and CaV3.3 activator. Enhances CaV3.1 and CaV3.3, but not CaV3.2 activity at concentrations of 0.01 - 10 M in neuro2A cells in vitro. Elevates ACh levels in hippocampus. Rescues impaired memory-related behaviors, promotes adult neurogenesis and displays antidepressant-like effects in OBX mice. Orally bioavailable.

Technical Data

M. Wt 369.41
Formula C20H23N3O4
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1256269-87-0
PubChem ID 71655974
InChI Key WZHBYTVHUFURPY-UHFFFAOYSA-N
Smiles O=C(C1=C(C2(N3C=CC=C(C3=NC2=O)C)CC1=O)N4CCCCC4)OCC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 36.94 100
1eq. HCl 36.94 100

Preparing Stock Solutions

The following data is based on the product molecular weight 369.41. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.71 mL 13.54 mL 27.07 mL
5 mM 0.54 mL 2.71 mL 5.41 mL
10 mM 0.27 mL 1.35 mL 2.71 mL
50 mM 0.05 mL 0.27 mL 0.54 mL

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References

References are publications that support the biological activity of the product.

Yabuki et al (2017) Pharmacological properties of SAK3, a novel T-type voltage-gated Ca2+ channel enhancer. Neuropharmacology 117 1 PMID: 28093211

Xu et al (2018) T-type calcium channel enhancer SAK3 produces anti-depressant-like effects by promoting adult hippocampal neurogenesis in olfactory bulbectomized mice. J.Pharmacol.Sci. 137 333 PMID: 30196018


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Keywords: SAK 3, SAK 3 supplier, SAK3, voltage-gated, Ca2+, channels, T-VGCC, memory, orally, bioavailable, CaV3.1, Ca3.3, activators, activates, Cav3.x, Channels, 6239, Tocris Bioscience

Citations for SAK 3

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Literature in this Area

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