Pricing Availability   Qty
Description: Potent CaV3.1 and 3.3 activator; orally bioavailable
Chemical Name: Ethyl 8'-methyl-2',4-dioxo-2-(piperidin-1-yl)-2'H-spiro[cyclopent[2]ene-1,3'-imidazo[1,2-a]pyridine]-3-carboxylate
Purity: ≥98% (HPLC)

Biological Activity for SAK 3

SAK 3 is a potent CaV3.1 and CaV3.3 activator. Enhances CaV3.1 and CaV3.3, but not CaV3.2 activity at concentrations of 0.01 - 10 M in neuro2A cells in vitro. Elevates ACh levels in hippocampus. Rescues impaired memory-related behaviors, promotes adult neurogenesis and displays antidepressant-like effects in OBX mice. Orally bioavailable.

Compound Libraries for SAK 3

SAK 3 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for SAK 3

M. Wt 369.41
Formula C20H23N3O4
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1256269-87-0
PubChem ID 71655974
Smiles O=C(C1=C(C2(N3C=CC=C(C3=NC2=O)C)CC1=O)N4CCCCC4)OCC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for SAK 3

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 36.94 100
1eq. HCl 36.94 100

Preparing Stock Solutions for SAK 3

The following data is based on the product molecular weight 369.41. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.71 mL 13.54 mL 27.07 mL
5 mM 0.54 mL 2.71 mL 5.41 mL
10 mM 0.27 mL 1.35 mL 2.71 mL
50 mM 0.05 mL 0.27 mL 0.54 mL

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References for SAK 3

References are publications that support the biological activity of the product.

Yabuki et al (2017) Pharmacological properties of SAK3, a novel T-type voltage-gated Ca2+ channel enhancer. Neuropharmacology 117 1 PMID: 28093211

Xu et al (2018) T-type calcium channel enhancer SAK3 produces anti-depressant-like effects by promoting adult hippocampal neurogenesis in olfactory bulbectomized mice. J.Pharmacol.Sci. 137 333 PMID: 30196018

If you know of a relevant reference for SAK 3, please let us know.

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Keywords: SAK 3, SAK 3 supplier, SAK3, voltage-gated, Ca2+, channels, T-VGCC, memory, orally, bioavailable, CaV3.1, Ca3.3, activators, activates, Cav3.x, Channels, 6239, Tocris Bioscience

Citations for SAK 3

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