ML 218 hydrochloride

Pricing Availability   Qty
Description: CaV3.x blocker
Chemical Name: 3,5-Dichloro-N-[[(1α,5α,6-exo,6α)-3-(3,3-dimethylbutyl)-3-azabicyclo[3.1.0]hex-6-yl]methyl]-benzamide hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations (6)
Reviews

Biological Activity for ML 218 hydrochloride

ML 218 hydrochloride is a selective inhibitor of T-type calcium channels (IC50 values are 270 and 310 nM for Cav3.3 and Cav3.2 respectively in a patch EP assay). Decreases burst activity in STN neurons; reduces cataleptic behaviour in an in vivo rat model of Parkinson's disease. Displays no significant inhibition of L- or N-type calcium channels, Kir6 (KATP) or KV11.1 (hERG) potassium channels. ML 218 hydrochloride inhibits oral cancer cell proliferation. Orally active.

Compound Libraries for ML 218 hydrochloride

ML 218 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for ML 218 hydrochloride

M. Wt 405.79
Formula C19H26Cl2N2O.HCl
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 2319922-08-0
PubChem ID 2723792
InChI Key JIQFFACVQXXHMY-YDALLXLXSA-N
Smiles CC(C)(C)CCN1C[C@@]2([H])[C@@]([C@@H]2CNC(C3=CC(Cl)=CC(Cl)=C3)=O)([H])C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for ML 218 hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 36.93 100
ethanol 36.93 100

Preparing Stock Solutions for ML 218 hydrochloride

The following data is based on the product molecular weight 405.79. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.46 mL 12.32 mL 24.64 mL
5 mM 0.49 mL 2.46 mL 4.93 mL
10 mM 0.25 mL 1.23 mL 2.46 mL
50 mM 0.05 mL 0.25 mL 0.49 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets for ML 218 hydrochloride

References for ML 218 hydrochloride

References are publications that support the biological activity of the product.

Xiang et al (2011) The discovery and characterization of ML218: A novel, centrally active T-type calcium channel inhibitor with robust effects in STN neurons and in a rodent model of Parkinson's disease. ACS Chem.Neurosci. 2 730 PMID: 22368764

Galvan et al (2016) Lack of antiparkinsonian effects of systemic injections of the specific T-type calcium channel blocker ML218 in MPTP-treated monkeys. ACS Chem.Neurosci 7 1543 PMID: 27596273

Chakraborty et al (2021) ML218 HCl is more efficient than capsaicin in inhibiting bacterial antigen-induced Cal 27 oral cancer cell proliferation. Int.J.Mol.Sci. 22 12559 PMID: 34830441


If you know of a relevant reference for ML 218 hydrochloride, please let us know.

View Related Products by Product Action

View all CaV3.x Channel (T-type) Blockers

Keywords: ML 218 hydrochloride, ML 218 hydrochloride supplier, ML218, HCl, CID45115620, T-type, calcium, channels, CAV3.1, CAV3.2, CAV3.3, inhibitors, inhibits, selective, Cav3.x, Channels, 4507, Tocris Bioscience

6 Citations for ML 218 hydrochloride

Citations are publications that use Tocris products. Selected citations for ML 218 hydrochloride include:

Nisha et al (2015) T-type calcium channels contribute to calcium disturbances in brain during hyponatremia. Exp Neurol 273 105-13 PMID: 26257025

Artem M et al (2021) Role of L-Type Voltage-Gated Calcium Channels in Epileptiform Activity of Neurons. Int J Mol Sci 22 PMID: 34638683

Pascual-Caro et al (2018) STIM1 deficiency is linked to Alzheimer's disease and triggers cell death in SH-SY5Y cells by upregulation of L-type voltage-operated Ca2+ entry. J Mol Med (Berl) 96 1061 PMID: 30088035

Galvan et al (2016) Lack of antiparkinsonian effects of systemic injections of the specific T-type calcium channel blocker ML218 in MPTP-treated monkeys. ACS Chem.Neurosci. 7 1543 PMID: 27596273


Do you know of a great paper that uses ML 218 hydrochloride from Tocris? Please let us know.

Reviews for ML 218 hydrochloride

There are currently no reviews for this product. Be the first to review ML 218 hydrochloride and earn rewards!

Have you used ML 218 hydrochloride?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review