NNC 55-0396 dihydrochloride
Highly selective T-type calcium channel blocker. Displays IC50 values of 6.8 and > 100 μM for inhibition of Cav3.1 T-type channels and HVA currents respectively in INS-1 cells.
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 564.57. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.77 mL||8.86 mL||17.71 mL|
|5 mM||0.35 mL||1.77 mL||3.54 mL|
|10 mM||0.18 mL||0.89 mL||1.77 mL|
|50 mM||0.04 mL||0.18 mL||0.35 mL|
References are publications that support the products' biological activity.
Huang et al (2004) NNC 55-0396 [(1S,2S)-2-(2-(N-[(3-benzimidazol-2-yl)propyl]-N-methylamino)ethyl)-6-fluoro-1,2,3,4-tetrahydro-1-isopropyl-2-naphtyl cyclopropanecarboxylate dihydrochloride]: A new selective inhibitor of T-type calcium cha J.Pharmacol.Exp.Ther. 309 193 PMID: 14718587
Chen et al (2010) CaV3.2 T-type Ca2+ channel-dependent activation of ERK in paraventricular thalamus modulates acid-induced chronic muscle pain. J.Neurosci. 30 10360 PMID: 20685979
If you know of a relevant reference for NNC 55-0396 dihydrochloride, please let us know.
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Keywords: NNC 55-0396 dihydrochloride, supplier, selective, Ca2+, channel, blockers, T-type, Calcium, CaV, Channels, T-Type, voltage-gated, voltage-dependent, NNC550396, dihydrochloride, Voltage-gated, Calcium, Channels, Voltage-gated, Calcium, Channels, Tocris Bioscience
5 Citations for NNC 55-0396 dihydrochloride
Citations are publications that use Tocris products. Selected citations for NNC 55-0396 dihydrochloride include:
Baillie et al (2012) Sumatriptan inhibition of N-type calcium channel mediated signaling in dural CGRP terminal fibres. Am J Physiol Regul Integr Comp Physiol 63 362 PMID: 22691374
Abe et al (2011) The Etv1/Er81 transcription factor orchestrates activity-dependent gene regulation in the terminal maturation program of cerebellar granule cells. PLoS One 108 12497 PMID: 21746923
Senadheera et al (2013) Enhanced contractility in pregnancy is associated with augmented TRPC3, L-type, and T-type voltage-dependent calcium channel function in rat uterine radial artery. Proc Natl Acad Sci U S A 305 R917 PMID: 23948776
Tzeng et al (2012) The Ca(v)3.1 T-type calcium channel is required for neointimal formation in response to vascular injury in mice. Cardiovasc Res 96 533 PMID: 22886848
Kuo et al (2010) Dihydropyridine-insensitive calcium currents contribute to function of small cerebral arteries. J Cereb Blood Flow Metab 30 1226 PMID: 20125181
Do you know of a great paper that uses NNC 55-0396 dihydrochloride from Tocris? If so please let us know.
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