NNC 55-0396 dihydrochloride

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Cat.No. 2268 - NNC 55-0396 dihydrochloride | C30H38FN3O2.2HCl | CAS No. 357400-13-6
Description: Highly selective Ca2+ channel blocker (T-type)
Chemical Name: (1S,2S)-2-[2-[[3-(1H-Benzimidazol-2-yl)propyl]methylamino]ethyl]-6-fluoro-1,2,3,4-tetrahydro-1-(1-methylethyl)-2-naphthalenyl cyclopropanecarboxylate dihydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations (5)
Literature

Biological Activity

Highly selective T-type calcium channel blocker. Displays IC50 values of 6.8 and > 100 μM for inhibition of Cav3.1 T-type channels and HVA currents respectively in INS-1 cells.

Technical Data

M. Wt 564.57
Formula C30H38FN3O2.2HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 357400-13-6
PubChem ID 22084904
InChI Key BCCQNBXHUMKLFW-HNQRYHMESA-N
Smiles FC1=CC(CC[C@@](CCN(C)CCCC3=NC(C=CC=C5)=C5N3)(OC(C4CC4)=O)[C@H]2[C@H](C)C)=C2C=C1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 14.11 25

Preparing Stock Solutions

The following data is based on the product molecular weight 564.57. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.77 mL 8.86 mL 17.71 mL
5 mM 0.35 mL 1.77 mL 3.54 mL
10 mM 0.18 mL 0.89 mL 1.77 mL
50 mM 0.04 mL 0.18 mL 0.35 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Huang et al (2004) NNC 55-0396 [(1S,2S)-2-(2-(N-[(3-benzimidazol-2-yl)propyl]-N-methylamino)ethyl)-6-fluoro-1,2,3,4-tetrahydro-1-isopropyl-2-naphtyl cyclopropanecarboxylate dihydrochloride]: A new selective inhibitor of T-type calcium cha J.Pharmacol.Exp.Ther. 309 193 PMID: 14718587

Chen et al (2010) CaV3.2 T-type Ca2+ channel-dependent activation of ERK in paraventricular thalamus modulates acid-induced chronic muscle pain. J.Neurosci. 30 10360 PMID: 20685979


If you know of a relevant reference for NNC 55-0396 dihydrochloride, please let us know.

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View all Voltage-gated Calcium Channel (CaV) Blockers

Keywords: selective Ca2+ channel blockers T-type Calcium CaV Channels T-Type voltage-gated voltage-dependent NNC550396 dihydrochloride Voltage-gated Calcium Channels

5 Citations for NNC 55-0396 dihydrochloride

Citations are publications that use Tocris products. Selected citations for NNC 55-0396 dihydrochloride include:

Baillie et al (2012) Sumatriptan inhibition of N-type calcium channel mediated signaling in dural CGRP terminal fibres. Am J Physiol Regul Integr Comp Physiol 63 362 PMID: 22691374

Abe et al (2011) The Etv1/Er81 transcription factor orchestrates activity-dependent gene regulation in the terminal maturation program of cerebellar granule cells. PLoS One 108 12497 PMID: 21746923

Kuo et al (2010) Dihydropyridine-insensitive calcium currents contribute to function of small cerebral arteries. J Cereb Blood Flow Metab 30 1226 PMID: 20125181

Senadheera et al (2013) Enhanced contractility in pregnancy is associated with augmented TRPC3, L-type, and T-type voltage-dependent calcium channel function in rat uterine radial artery. Proc Natl Acad Sci U S A 305 R917 PMID: 23948776

Tzeng et al (2012) The Ca(v)3.1 T-type calcium channel is required for neointimal formation in response to vascular injury in mice. Cardiovasc Res 96 533 PMID: 22886848


Do you know of a great paper that uses NNC 55-0396 dihydrochloride from Tocris? If so please let us know.

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