NNC 55-0396 dihydrochloride

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Cat.No. 2268 - NNC 55-0396 dihydrochloride | C30H38FN3O2.2HCl | CAS No. 357400-13-6
Description: Highly selective CaV3.x blocker
Chemical Name: (1S,2S)-2-[2-[[3-(1H-Benzimidazol-2-yl)propyl]methylamino]ethyl]-6-fluoro-1,2,3,4-tetrahydro-1-(1-methylethyl)-2-naphthalenyl cyclopropanecarboxylate dihydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations (9)
Reviews
Literature (3)

Biological Activity

Highly selective T-type calcium channel blocker. Displays IC50 values of 6.8 and > 100 μM for inhibition of Cav3.1 T-type channels and HVA currents respectively in INS-1 cells.

Technical Data

M. Wt 564.57
Formula C30H38FN3O2.2HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 357400-13-6
PubChem ID 22084904
InChI Key BCCQNBXHUMKLFW-HNQRYHMESA-N
Smiles FC1=CC(CC[C@@](CCN(C)CCCC3=NC(C=CC=C5)=C5N3)(OC(C4CC4)=O)[C@H]2[C@H](C)C)=C2C=C1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 14.11 25

Preparing Stock Solutions

The following data is based on the product molecular weight 564.57. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.25 mM 7.09 mL 35.43 mL 70.85 mL
1.25 mM 1.42 mL 7.09 mL 14.17 mL
2.5 mM 0.71 mL 3.54 mL 7.09 mL
12.5 mM 0.14 mL 0.71 mL 1.42 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Huang et al (2004) NNC 55-0396 [(1S,2S)-2-(2-(N-[(3-benzimidazol-2-yl)propyl]-N-methylamino)ethyl)-6-fluoro-1,2,3,4-tetrahydro-1-isopropyl-2-naphtyl cyclopropanecarboxylate dihydrochloride]: A new selective inhibitor of T-type calcium cha J.Pharmacol.Exp.Ther. 309 193 PMID: 14718587

Chen et al (2010) CaV3.2 T-type Ca2+ channel-dependent activation of ERK in paraventricular thalamus modulates acid-induced chronic muscle pain. J.Neurosci. 30 10360 PMID: 20685979


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View Related Products by Product Action

View all CaV3.x Channel (T-type) Blockers

Keywords: NNC 55-0396 dihydrochloride, NNC 55-0396 dihydrochloride supplier, selective, Ca2+, channel, blockers, T-type, Calcium, CaV, Channels, T-Type, voltage-gated, voltage-dependent, NNC550396, dihydrochloride, Cav3.x, 2268, Tocris Bioscience

9 Citations for NNC 55-0396 dihydrochloride

Citations are publications that use Tocris products. Selected citations for NNC 55-0396 dihydrochloride include:

Schneider et al (2013) Calcium-based dendritic excitability and its regulation in the deep cerebellar nuclei. J Neurophysiol 109 2282 PMID: 23427305

Tzeng et al (2012) The Ca(v)3.1 T-type calcium channel is required for neointimal formation in response to vascular injury in mice. Cardiovasc Res 96 533 PMID: 22886848

Kuo et al (2010) Dihydropyridine-insensitive calcium currents contribute to function of small cerebral arteries. J Cereb Blood Flow Metab 30 1226 PMID: 20125181

Chen et al (2010) Ca(v)3.2 T-type Ca2+ channel-dependent activation of ERK in paraventricular thalamus modulates acid-induced chronic muscle pain. J Neurosci 30 10360 PMID: 20685979


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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

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