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CaV3.2 channel blocker (IC50 = 2.3 μM). Also blocks low voltage-activated (CaV3.1) currents in native rat DRG neurons (IC50 = 7.6 μM). Exhibits little or no activity at other ion channels and receptors. Displays antinociceptive effects in a mechanical hyperalgesia model in vivo. Orally bioavailable.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 455.91. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.2 mM||10.97 mL||54.84 mL||109.67 mL|
|1 mM||2.19 mL||10.97 mL||21.93 mL|
|2 mM||1.1 mL||5.48 mL||10.97 mL|
|10 mM||0.22 mL||1.1 mL||2.19 mL|
References are publications that support the biological activity of the product.
Zhang et al (2015) Optimization of ADME properties for sulfonamides leading to the discovery of a T-type calcium channel blocker, ABT-639. ACS Med.Chem.Lett. 6 641 PMID: 26101566
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Keywords: ABT 639, ABT 639 supplier, ABT639, T-type, calcium, channel, blockers, blocks, CaV3.2, CaV3.1, antinociceptive, orally, bioavailable, Cav3.x, Channels, 6770, Tocris Bioscience
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