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ABT 639

Cat. No. 6770 Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: CaV3.2 and CaV3.1 channel blocker; orally bioavailable
Chemical Name: 4-Chloro-2-fluoro-N-(2-fluorophenyl)-5-[[(8aR)-hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl]carbonyl]benzenesulfonamide
Purity: ≥98% (HPLC)
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Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for ABT 639

ABT 639 is a CaV3.2 channel blocker (IC50 = 2.3 μM). Also blocks low voltage-activated (CaV3.1) currents in native rat DRG neurons (IC50 = 7.6 μM). Exhibits little or no activity at other ion channels and receptors. Displays antinociceptive effects in a mechanical hyperalgesia model in vivo. Orally bioavailable.

Compound Libraries for ABT 639

ABT 639 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for ABT 639

M. Wt 455.91
Formula C20H20ClF2N3O3S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1235560-28-7
PubChem ID 46851313
InChI Key AGPIHNZOZNKRGT-CYBMUJFWSA-N
Smiles [H][C@]12CCCN1CCN(C(C3=CC(S(=O)(NC4=C(C=CC=C4)F)=O)=C(C=C3Cl)F)=O)C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for ABT 639

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 9.12 20

Preparing Stock Solutions for ABT 639

The following data is based on the product molecular weight 455.91. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 10.97 mL 54.84 mL 109.67 mL
1 mM 2.19 mL 10.97 mL 21.93 mL
2 mM 1.1 mL 5.48 mL 10.97 mL
10 mM 0.22 mL 1.1 mL 2.19 mL

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References for ABT 639

References are publications that support the biological activity of the product.

Zhang et al (2015) Optimization of ADME properties for sulfonamides leading to the discovery of a T-type calcium channel blocker, ABT-639. ACS Med.Chem.Lett. 6 641 PMID: 26101566

If you know of a relevant reference for ABT 639, please let us know.

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Citations for ABT 639

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