ABT 639

Pricing Availability   Qty
Cat.No. 6770 - ABT 639 | C20H20ClF2N3O3S | CAS No. 1235560-28-7
Description: CaV3.2 and CaV3.1 channel blocker; orally bioavailable
Chemical Name: 4-Chloro-2-fluoro-N-(2-fluorophenyl)-5-[[(8aR)-hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl]carbonyl]benzenesulfonamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (3)

Biological Activity

CaV3.2 channel blocker (IC50 = 2.3 μM). Also blocks low voltage-activated (CaV3.1) currents in native rat DRG neurons (IC50 = 7.6 μM). Exhibits little or no activity at other ion channels and receptors. Displays antinociceptive effects in a mechanical hyperalgesia model in vivo. Orally bioavailable.

Technical Data

M. Wt 455.91
Formula C20H20ClF2N3O3S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1235560-28-7
PubChem ID 46851313
InChI Key AGPIHNZOZNKRGT-CYBMUJFWSA-N
Smiles [H][C@]12CCCN1CCN(C(C3=CC(S(=O)(NC4=C(C=CC=C4)F)=O)=C(C=C3Cl)F)=O)C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 9.12 20

Preparing Stock Solutions

The following data is based on the product molecular weight 455.91. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 10.97 mL 54.84 mL 109.67 mL
1 mM 2.19 mL 10.97 mL 21.93 mL
2 mM 1.1 mL 5.48 mL 10.97 mL
10 mM 0.22 mL 1.1 mL 2.19 mL

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References

References are publications that support the biological activity of the product.

Zhang et al (2015) Optimization of ADME properties for sulfonamides leading to the discovery of a T-type calcium channel blocker, ABT-639. ACS Med.Chem.Lett. 6 641 PMID: 26101566


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Keywords: ABT 639, ABT 639 supplier, ABT639, T-type, calcium, channel, blockers, blocks, CaV3.2, CaV3.1, antinociceptive, orally, bioavailable, Cav3.x, Channels, 6770, Tocris Bioscience

Citations for ABT 639

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Literature in this Area

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