ABT 639

Pricing Availability   Qty
Description: CaV3.2 and CaV3.1 channel blocker; orally bioavailable
Chemical Name: 4-Chloro-2-fluoro-N-(2-fluorophenyl)-5-[[(8aR)-hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl]carbonyl]benzenesulfonamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews

Biological Activity for ABT 639

ABT 639 is a CaV3.2 channel blocker (IC50 = 2.3 μM). Also blocks low voltage-activated (CaV3.1) currents in native rat DRG neurons (IC50 = 7.6 μM). Exhibits little or no activity at other ion channels and receptors. Displays antinociceptive effects in a mechanical hyperalgesia model in vivo. Orally bioavailable.

Compound Libraries for ABT 639

ABT 639 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for ABT 639

M. Wt 455.91
Formula C20H20ClF2N3O3S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1235560-28-7
PubChem ID 46851313
InChI Key AGPIHNZOZNKRGT-CYBMUJFWSA-N
Smiles [H][C@]12CCCN1CCN(C(C3=CC(S(=O)(NC4=C(C=CC=C4)F)=O)=C(C=C3Cl)F)=O)C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for ABT 639

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 9.12 20

Preparing Stock Solutions for ABT 639

The following data is based on the product molecular weight 455.91. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 10.97 mL 54.84 mL 109.67 mL
1 mM 2.19 mL 10.97 mL 21.93 mL
2 mM 1.1 mL 5.48 mL 10.97 mL
10 mM 0.22 mL 1.1 mL 2.19 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References for ABT 639

References are publications that support the biological activity of the product.

Zhang et al (2015) Optimization of ADME properties for sulfonamides leading to the discovery of a T-type calcium channel blocker, ABT-639. ACS Med.Chem.Lett. 6 641 PMID: 26101566


If you know of a relevant reference for ABT 639, please let us know.

View Related Products by Product Action

View all CaV3.x Channel (T-type) Blockers

Keywords: ABT 639, ABT 639 supplier, ABT639, T-type, calcium, channel, blockers, blocks, CaV3.2, CaV3.1, antinociceptive, orally, bioavailable, Cav3.x, Channels, 6770, Tocris Bioscience

Citations for ABT 639

Citations are publications that use Tocris products.

Currently there are no citations for ABT 639. Do you know of a great paper that uses ABT 639 from Tocris? Please let us know.

Reviews for ABT 639

There are currently no reviews for this product. Be the first to review ABT 639 and earn rewards!

Have you used ABT 639?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review