Z 944

Pricing Availability   Qty
Description: CaV3.x blocker
Chemical Name: 4-[[(3-Chloro-5-fluorobenzoyl)amino)methyl]-N-(1,1-dimethylethyl)-1-piperidineacetamide
Purity: ≥98% (HPLC)
Literature (3)

Biological Activity for Z 944

Z 944 is a selective T-type Ca2+ channel blocker (IC50 values are 50 to 160 nM for hCav3.1, hCav3.2 and hCav3.3). Exhibits 50 to 600 fold selectivity for Cav3.x channels over related ion channels (Cav1.2, hERG and Nav1.5). Has no effect on action potential properties in isolated heart Purkinje fibers and no adverse effects on ECG parameters in vivo. Exhibits anti-seizure effects in animal models.

Compound Libraries for Z 944

Z 944 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Z 944

M. Wt 383.89
Formula C19H27ClFN3O2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1199236-64-0
PubChem ID 44540045
Smiles CC(C)(NC(CN1CCC(CC1)CNC(C2=CC(Cl)=CC(F)=C2)=O)=O)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Z 944

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 38.39 100
ethanol 38.39 100

Preparing Stock Solutions for Z 944

The following data is based on the product molecular weight 383.89. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.6 mL 13.02 mL 26.05 mL
5 mM 0.52 mL 2.6 mL 5.21 mL
10 mM 0.26 mL 1.3 mL 2.6 mL
50 mM 0.05 mL 0.26 mL 0.52 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

References for Z 944

References are publications that support the biological activity of the product.

Tringham et al (2012) T-type calcium channel blockers that attenuate thalamic burst firing and suppress absence seizures. Sci.Transl.Med. 4 121 PMID: 22344687

Casillas-Espinosa et al (2015) Z944, a novel selective T-type calcium channel antagonist delays the progression of seizures in the amygdala kindling model. PLoS One. 10 e0130012 PMID: 26274319

If you know of a relevant reference for Z 944, please let us know.

View Related Products by Product Action

View all CaV3.x Channel (T-type) Blockers

Keywords: Z 944, Z 944 supplier, Z944, T-type, calcium, channel, blockers, anti-epileptic, in, vivo, Cav3.1, Cav3.2, Cav3.3, Ca2+, blocks, Cav3.x, Channels, 6367, Tocris Bioscience

Citations for Z 944

Citations are publications that use Tocris products.

Currently there are no citations for Z 944. Do you know of a great paper that uses Z 944 from Tocris? Please let us know.

Reviews for Z 944

There are currently no reviews for this product. Be the first to review Z 944 and earn rewards!

Have you used Z 944?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Cardiovascular Research Product Guide

Cardiovascular Research Product Guide

A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:

  • Hypertension
  • Thrombosis and Hemostasis
  • Atherosclerosis
  • Myocardial Infarction
  • Ischemia/Reperfusion Injury
  • Arrhythmias
  • Heart Failure
Ion Channel Product Listing

Ion Channel Product Listing

A collection of around 500 products for ion channel research, the listing includes research tools for the study of:

  • Ligand-gated ion channels
  • Voltage-gated ion channels
  • Other Ion Channels
Neurotransmission Product Guide

Neurotransmission Product Guide

A collection of over 250 products for neurotransmission research, the guide includes research tools for the study of:

  • Dopaminergic Transmission
  • Glutamatergic Transmission
  • Opioid Peptide Transmission
  • Serotonergic Transmission
  • Chemogenetics