PF 5006739

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Description: Potent CK1δ/ε inhibitor
Chemical Name: 4-[4-(4-Fluorophenyl)-1-[1-(3-isoxazolylmethyl)-4-piperidinyl]-1H-imidazol-5-yl]-2-pyrimidinamine
Purity: ≥98% (HPLC)
Literature (1)

Biological Activity for PF 5006739

PF 5006739 is a potent casein kinase 1δ/ε inhibitor (IC50 values are 3.9 and 17 nM, respectively). Mediates circadian rhythm phase-delaying effects in vivo. Attenuates opioid drug seeking behavior in addiction in vivo models.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Compound Libraries for PF 5006739

PF 5006739 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for PF 5006739

M. Wt 419.46
Formula C22H22FN7O
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1293395-67-1
PubChem ID 51353555
Smiles NC1=NC(C2=C(C3=CC=C(F)C=C3)N=CN2C4CCN(CC5=NOC=C5)CC4)=CC=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for PF 5006739

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 41.95 100

Preparing Stock Solutions for PF 5006739

The following data is based on the product molecular weight 419.46. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.38 mL 11.92 mL 23.84 mL
5 mM 0.48 mL 2.38 mL 4.77 mL
10 mM 0.24 mL 1.19 mL 2.38 mL
50 mM 0.05 mL 0.24 mL 0.48 mL

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Product Datasheets for PF 5006739

Certificate of Analysis / Product Datasheet
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References for PF 5006739

References are publications that support the biological activity of the product.

Wager et al (2014) Casein kinase 1δ/ε inhibitor PF-5006739 attenuates opioid drug-seeking behavior. ACS Chem.Neurosci. 5 1253 PMID: 25299732

If you know of a relevant reference for PF 5006739, please let us know.

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View all Casein Kinase 1 Inhibitors

Keywords: PF 5006739, PF 5006739 supplier, PF5006739, Casesin, kinase, 1δ/ε, delta, epsilon, inhibitors, inhibits, circadian, rhythm, opioid, drug, seeking, behaviour, addiction, Casein, Kinase, 1, 6346, Tocris Bioscience

Citations for PF 5006739

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Currently there are no citations for PF 5006739. Do you know of a great paper that uses PF 5006739 from Tocris? Please let us know.

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Literature in this Area

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