PF 5006739

Pricing Availability Delivery Time Qty
Cat.No. 6346 - PF 5006739 | C22H22FN7O | CAS No. 1293395-67-1
Description: Potent CK1δ/ε inhibitor
Chemical Name: 4-[4-(4-Fluorophenyl)-1-[1-(3-isoxazolylmethyl)-4-piperidinyl]-1H-imidazol-5-yl]-2-pyrimidinamine
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Potent casesin kinase 1δ/ε inhibitor (IC50 values are 3.9 and 17 nM, respectively). Mediates circadian rhythm phase-delaying effects in vivo. Attenuates opioid drug seeking behaviour in addiction in vivo models.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data

M. Wt 419.46
Formula C22H22FN7O
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1293395-67-1
PubChem ID 51353555
InChI Key XPWHRQHBPRSUAW-UHFFFAOYSA-N
Smiles NC1=NC(C2=C(C3=CC=C(F)C=C3)N=CN2C4CCN(CC5=NOC=C5)CC4)=CC=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 41.95 100

Preparing Stock Solutions

The following data is based on the product molecular weight 419.46. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.38 mL 11.92 mL 23.84 mL
5 mM 0.48 mL 2.38 mL 4.77 mL
10 mM 0.24 mL 1.19 mL 2.38 mL
50 mM 0.05 mL 0.24 mL 0.48 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Wager et al (2014) Casein kinase 1δ/ε inhibitor PF-5006739 attenuates opioid drug-seeking behavior. ACS Chem.Neurosci. 5 1253 PMID: 25299732


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View all Casein Kinase 1 Inhibitors

Keywords: PF 5006739, supplier, PF5006739, Casesin, kinase, 1δ/ε, delta, epsilon, inhibitors, inhibits, circadian, rhythm, opioid, drug, seeking, behaviour, addiction, Casein, Kinase, 1, Casein, Kinase, 1, Tocris Bioscience

Citations for PF 5006739

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