PF 670462

Pricing Availability   Qty
Description: Potent and selective CK1ε and CK1δ inhibitor
Chemical Name: 4-[1-Cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]-2-pyrimidinamine dihydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations (12)
Reviews
Literature (1)

Biological Activity for PF 670462

PF 670462 is a potent and selective casein kinase 1ε (CK1ε) and CK1δ inhibitor (IC50 values are 7.7 and 14 nM respectively) that displays > 30-fold selectivity over 42 other common kinases. Inhibits PER protein nuclear translocation (EC50 = 290 nM) causing phase shifts in circadian rhythms and attenuates methamphetamine-stimulated locomotion in vivo.

Compound Libraries for PF 670462

PF 670462 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Kinase Inhibitor Library. Find out more about compound libraries available from Tocris.

Technical Data for PF 670462

M. Wt 410.32
Formula C19H20FN5.2HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 950912-80-8
PubChem ID 51049607
InChI Key PSNKGVAXBSAHCH-UHFFFAOYSA-N
Smiles NC1=NC=CC(C2=C(C4=CC=C(F)C=C4)N=CN2C3CCCCC3)=N1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for PF 670462

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 41.03 100

Preparing Stock Solutions for PF 670462

The following data is based on the product molecular weight 410.32. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.44 mL 12.19 mL 24.37 mL
5 mM 0.49 mL 2.44 mL 4.87 mL
10 mM 0.24 mL 1.22 mL 2.44 mL
50 mM 0.05 mL 0.24 mL 0.49 mL

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Product Datasheets for PF 670462

Certificate of Analysis / Product Datasheet
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References for PF 670462

References are publications that support the biological activity of the product.

Badura et al (2007) An inhibitor of casein kinase Iε induces phase delays in circadian rhythms under free-running and entrained conditions. J.Pharmacol.Exp.Ther. 322 730 PMID: 17502429

Bryant et al (2009) A role for casein kinase 1 epsilon in the locomotor stimulant response to metha. Psychopharmacology 203 703 PMID: 19050854

Sprose et al (2009) Inhibition of casein kinase I ε/δ produces phase shifts in the circadian rhythms of Cynomolgus monkeys. Psychopharmacology 204 735 PMID: 19277609


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View Related Products by Target

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View all Casein Kinase 1 Inhibitors

Keywords: PF 670462, PF 670462 supplier, Potent, selective, CK1ε, CK1epsilon, CK1δ, CK1delta, inhibitors, inhibits, Casein, Kinases, 1, PF670462, circadian, rhythms, Kinase, 3316, Tocris Bioscience

12 Citations for PF 670462

Citations are publications that use Tocris products. Selected citations for PF 670462 include:

Zhang et al (2018) Oncogenic RAS-induced CK1α drives nuclear FOXO proteolysis. Oncogene 37 363 PMID: 28945225

Krulikas et al (2018) Application of Integrated Drug Screening/Kinome Analysis to Identify Inhibitors of dFdCyd-Resistant Pancreatic Cancer Cell Growth. SLAS Discov 23 850 PMID: 29742358

Kurihara et al (2014) Alleviation of behavioral hypersensitivity in mouse models of inflammatory pain with two structurally different casein kinase 1 (CK1) inhibitors. Mol Pain 10 17 PMID: 24612480

Zemp et al (2014) CK1δ and CK1ε are components of human 40S subunit precursors required for cytoplasmic 40S maturation. J Cell Sci 127 1242 PMID: 24424021


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Literature in this Area

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Cell Cycle and DNA Damage Research Product Guide

Cell Cycle and DNA Damage Research Product Guide

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