PF 4800567 hydrochloride

Pricing Availability   Qty
Description: Selective casein kinase 1ε inhibitor
Chemical Name: 3-[(3-Chlorophenoxy)methyl]-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine hydrochloride
Purity: ≥99% (HPLC)
Citations (5)
Literature (1)

Biological Activity for PF 4800567 hydrochloride

PF 4800567 hydrochloride is a selective casein kinase 1ε inhibitor; displays 22-fold greater potency towards CK1ε than CK1δ (IC50 values are 32 and 711 nM for CK1ε and CK1δ respectively). ATP competitive. Displays minimal effect on the circadian clock.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

External Portal Information for PF 4800567 hydrochloride is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of PF 4800567 is reviewed on the chemical probes website.

Compound Libraries for PF 4800567 hydrochloride

PF 4800567 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for PF 4800567 hydrochloride

M. Wt 396.27
Formula C17H18ClN5O2.HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 1391052-28-0
PubChem ID 71751553
Smiles NC1=C(C(COC4=CC(Cl)=CC=C4)=NN2C3CCOCC3)C2=NC=N1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for PF 4800567 hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 39.63 100

Preparing Stock Solutions for PF 4800567 hydrochloride

The following data is based on the product molecular weight 396.27. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.52 mL 12.62 mL 25.24 mL
5 mM 0.5 mL 2.52 mL 5.05 mL
10 mM 0.25 mL 1.26 mL 2.52 mL
50 mM 0.05 mL 0.25 mL 0.5 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Product Datasheets for PF 4800567 hydrochloride

Certificate of Analysis / Product Datasheet
Select another batch:

References for PF 4800567 hydrochloride

References are publications that support the biological activity of the product.

Walton et al (2009) Selective inhibition of casein kinase 1ε minimally alters circadian clock period. J.Pharmacol.Exp.Ther. 330 430 PMID: 19458106

Etchegaray et al (2010) Casein kinase 1 delta (CK1δ) regulates period length of the mouse suprachiasmatic circadian clock in vitro. PLoS One 5 e10303 PMID: 20421981

Meng et al (2010) Entrainment of disrupted circadian behavior through inhibition of casein kinase 1 (CK1) enzymes. Proc.Natl.Acad.Sci.USA 107 15240 PMID: 20696890

If you know of a relevant reference for PF 4800567 hydrochloride, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Casein Kinase 1 Inhibitors

Keywords: PF 4800567 hydrochloride, PF 4800567 hydrochloride supplier, pfizer, selective, casein, kinase, 1, ck1, ck1e, ck1epsilon, ck1ε, inhibitors, inhibits, PF4800567, hydrochloride, Casein, Kinase, 4281, Tocris Bioscience

5 Citations for PF 4800567 hydrochloride

Citations are publications that use Tocris products. Selected citations for PF 4800567 hydrochloride include:

Zhang et al (2013) Dissociation of circadian and circatidal timekeeping in the marine crustacean Eurydice pulchra. Curr Biol 23 1863 PMID: 24076244

Jing et al (2018) Methods for High-throughput Drug Combination Screening and Synergy Scoring. Methods Mol Biol 1711 351-398 PMID: 29344898

Oren et al (2015) Profiling molecular and behavioral circadian rhythms in the non-symbiotic sea anemone Nematostella vectensis. Mol Biol Cell 5 11418 PMID: 26081482

Zemp et al (2014) CK1δ and CK1ε are components of human 40S subunit precursors required for cytoplasmic 40S maturation. J Cell Sci 127 1242 PMID: 24424021

Cheong et al (2015) Casein kinase 1α-dependent feedback loop controls autophagy in RAS-driven cancers. J Clin Invest 125 1401 PMID: 25798617

Do you know of a great paper that uses PF 4800567 hydrochloride from Tocris? Please let us know.

Reviews for PF 4800567 hydrochloride

There are currently no reviews for this product. Be the first to review PF 4800567 hydrochloride and earn rewards!

Have you used PF 4800567 hydrochloride?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Cell Cycle and DNA Damage Research Product Guide

Cell Cycle and DNA Damage Research Product Guide

This product guide provides a review of the cell cycle and DNA damage research area and lists over 150 products, including research tools for:

  • Cell Cycle and Mitosis
  • DNA Damage Repair
  • Targeted Protein Degradation
  • Ubiquitin Proteasome Pathway
  • Chemotherapy Targets