PF 4800567 hydrochloride

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Cat.No. 4281 - PF 4800567 hydrochloride | C17H18ClN5O2.HCl | CAS No. 1391052-28-0
Description: Selective casein kinase 1ε inhibitor
Chemical Name: 3-[(3-Chlorophenoxy)methyl]-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations (3)
Literature

Biological Activity

Selective casein kinase 1ε inhibitor; displays 22-fold greater potency towards CK1ε than CK1δ (IC50 values are 32 and 711 nM for CK1ε and CK1δ respectively). ATP competitive. Displays minimal effect on the circadian clock.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

External Portal Information

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of PF 4800567 is reviewed on the chemical probes website.

Compound Libraries

PF 4800567 hydrochloride is also offered as part of the Tocriscreen Plus and Tocriscreen Kinase Inhibitor Toolbox II. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 396.27
Formula C17H18ClN5O2.HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 1391052-28-0
PubChem ID 71751553
InChI Key QZXZQMUZEHTFHD-UHFFFAOYSA-N
Smiles NC1=C(C(COC4=CC(Cl)=CC=C4)=NN2C3CCOCC3)C2=NC=N1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 39.63 100

Preparing Stock Solutions

The following data is based on the product molecular weight 396.27. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.52 mL 12.62 mL 25.24 mL
5 mM 0.5 mL 2.52 mL 5.05 mL
10 mM 0.25 mL 1.26 mL 2.52 mL
50 mM 0.05 mL 0.25 mL 0.5 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Walton et al (2009) Selective inhibition of casein kinase 1ε minimally alters circadian clock period. J.Pharmacol.Exp.Ther. 330 430 PMID: 19458106

Etchegaray et al (2010) Casein kinase 1 delta (CK1δ) regulates period length of the mouse suprachiasmatic circadian clock in vitro. PLoS One 5 e10303 PMID: 20421981

Meng et al (2010) Entrainment of disrupted circadian behavior through inhibition of casein kinase 1 (CK1) enzymes. Proc.Natl.Acad.Sci.USA 107 15240 PMID: 20696890


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View all Casein Kinase 1 Inhibitors

Keywords: pfizer selective casein kinase 1 ck1 ck1e ck1epsilon ck1ε inhibitors inhibits PF4800567 hydrochloride Casein Kinase 1

3 Citations for PF 4800567 hydrochloride

Citations are publications that use Tocris products. Selected citations for PF 4800567 hydrochloride include:

Cheong et al (2015) Casein kinase 1α-dependent feedback loop controls autophagy in RAS-driven cancers. J Clin Invest 125 1401 PMID: 25798617

Oren et al (2015) Profiling molecular and behavioral circadian rhythms in the non-symbiotic sea anemone Nematostella vectensis. Mol Biol Cell 5 11418 PMID: 26081482

Zemp et al (2014) CK1δ and CK1ε are components of human 40S subunit precursors required for cytoplasmic 40S maturation. J Cell Sci 127 1242 PMID: 24424021


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Pathways for PF 4800567 hydrochloride

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