CKI 7 dihydrochloride

Pricing Availability   Qty
Description: CK1 inhibitor
Chemical Name: N-(2-Aminoethyl)-5-chloro-8-isoquinolinesulfonamide dihydrochloride
Purity: ≥99% (HPLC)
Literature (1)

Biological Activity for CKI 7 dihydrochloride

CKI 7 dihydrochloride is a casein kinase 1 (CK1) inhibitor. Also inhibits SGK, S6K1 and MSK1. Induces retinal cell differentiation from human ESCs and iPSCs in combination with SB 431542 (Cat. No. 1614) and Y-27632 (Cat. No. 1254).

Compound Libraries for CKI 7 dihydrochloride

CKI 7 dihydrochloride is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Kinase Inhibitor Library and Tocriscreen Stem Cell Library. Find out more about compound libraries available from Tocris.

Technical Data for CKI 7 dihydrochloride

M. Wt 358.67
Formula C11H12ClN3O2S.2HCl
Storage Store at -20°C
Purity ≥99% (HPLC)
CAS Number 1177141-67-1
PubChem ID 16078955
Smiles ClC2=CC=C(S(NCCN)(=O)=O)C1=CN=CC=C12.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for CKI 7 dihydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
water 3.59 10
DMSO 17.93 50

Preparing Stock Solutions for CKI 7 dihydrochloride

The following data is based on the product molecular weight 358.67. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 5.58 mL 27.88 mL 55.76 mL
2.5 mM 1.12 mL 5.58 mL 11.15 mL
5 mM 0.56 mL 2.79 mL 5.58 mL
25 mM 0.11 mL 0.56 mL 1.12 mL

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Product Datasheets for CKI 7 dihydrochloride

Certificate of Analysis / Product Datasheet
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References for CKI 7 dihydrochloride

References are publications that support the biological activity of the product.

Osakada et al (2009) In vitro differentiation of retinal cells from human pluripotent stem cells by small-molecule induction. J.Cell Sci. 122 3169 PMID: 19671662

Rena et al (2004) D4476, a cell-permeant inhibitor of CK1, suppresses the site-specific phosphorylation and nuclear exclusion of FOXO1a. EMBO Rep. 5 60 PMID: 14710188

Peifer et al (2009) 3,4-Diaryl-isoxazoles and -imidazoles as potent dual inhibitors of p38α mitogen activated protein kinase and casein kinase 1δ. J.Med.Chem. 52 7618 PMID: 19591487

If you know of a relevant reference for CKI 7 dihydrochloride, please let us know.

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Citations for CKI 7 dihydrochloride

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