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CKI 7 dihydrochloride
Biological Activity for CKI 7 dihydrochloride
CKI 7 dihydrochloride is a casein kinase 1 (CK1) inhibitor. Also inhibits SGK, S6K1 and MSK1. Induces retinal cell differentiation from human ESCs and iPSCs in combination with SB 431542 (Cat. No. 1614) and Y-27632 (Cat. No. 1254).
Compound Libraries for CKI 7 dihydrochloride
CKI 7 dihydrochloride is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Kinase Inhibitor Library and Tocriscreen Stem Cell Library. Find out more about compound libraries available from Tocris.
Technical Data for CKI 7 dihydrochloride
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for CKI 7 dihydrochloride
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for CKI 7 dihydrochloride
The following data is based on the product molecular weight 358.67. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||5.58 mL||27.88 mL||55.76 mL|
|2.5 mM||1.12 mL||5.58 mL||11.15 mL|
|5 mM||0.56 mL||2.79 mL||5.58 mL|
|25 mM||0.11 mL||0.56 mL||1.12 mL|
Product Datasheets for CKI 7 dihydrochloride
References for CKI 7 dihydrochloride
References are publications that support the biological activity of the product.
Osakada et al (2009) In vitro differentiation of retinal cells from human pluripotent stem cells by small-molecule induction. J.Cell Sci. 122 3169 PMID: 19671662
Rena et al (2004) D4476, a cell-permeant inhibitor of CK1, suppresses the site-specific phosphorylation and nuclear exclusion of FOXO1a. EMBO Rep. 5 60 PMID: 14710188
Peifer et al (2009) 3,4-Diaryl-isoxazoles and -imidazoles as potent dual inhibitors of p38α mitogen activated protein kinase and casein kinase 1δ. J.Med.Chem. 52 7618 PMID: 19591487
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Keywords: CKI 7 dihydrochloride, CKI 7 dihydrochloride supplier, CKI7, dihydrochloride, casein, kinases, CK1, stem, cells, retinal, differentiation, ESCs, iPSCs, embryonic, induced, pluripotent, Casein, Kinase, 1, Retinal, Stem, Cells, and, iPSC, 5329, Tocris Bioscience
Citations for CKI 7 dihydrochloride
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Cell Cycle and DNA Damage Research Product Guide
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