CKI 7 dihydrochloride

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Cat.No. 5329 - CKI 7 dihydrochloride | C11H12ClN3O2S.2HCl | CAS No. 1177141-67-1
Description: CK1 inhibitor
Chemical Name: N-(2-Aminoethyl)-5-chloro-8-isoquinolinesulfonamide dihydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Casein kinase 1 (CK1) inhibitor. Also inhibits SGK, S6K1 and MSK1. Induces retinal cell differentiation from human ESCs and iPSCs in combination with SB 431542 (Cat. No. 1614) and Y-27632 (Cat. No. 1254).

Compound Libraries

CKI 7 dihydrochloride is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 358.67
Formula C11H12ClN3O2S.2HCl
Storage Store at -20°C
Purity ≥99% (HPLC)
CAS Number 1177141-67-1
PubChem ID 16078955
InChI Key JUAVTXYOCISSSL-UHFFFAOYSA-N
Smiles ClC2=CC=C(S(NCCN)(=O)=O)C1=CN=CC=C12.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 17.93 50
water 7.17 20

Preparing Stock Solutions

The following data is based on the product molecular weight 358.67. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.79 mL 13.94 mL 27.88 mL
5 mM 0.56 mL 2.79 mL 5.58 mL
10 mM 0.28 mL 1.39 mL 2.79 mL
50 mM 0.06 mL 0.28 mL 0.56 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Osakada et al (2009) In vitro differentiation of retinal cells from human pluripotent stem cells by small-molecule induction. J.Cell Sci. 122 3169 PMID: 19671662

Rena et al (2004) D4476, a cell-permeant inhibitor of CK1, suppresses the site-specific phosphorylation and nuclear exclusion of FOXO1a. EMBO Rep. 5 60 PMID: 14710188

Peifer et al (2009) 3,4-Diaryl-isoxazoles and -imidazoles as potent dual inhibitors of p38α mitogen activated protein kinase and casein kinase 1δ. J.Med.Chem. 52 7618 PMID: 19591487


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View all Casein Kinase 1 Inhibitors

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Citations for CKI 7 dihydrochloride

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Pathways for CKI 7 dihydrochloride

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