Formoterol hemifumarate

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Cat.No. 1448 - Formoterol hemifumarate | C19H24N2O4.½C4H4O4 | CAS No. 43229-80-7
Description: Potent and selective β2 agonist
Alternative Names: BD 40A
Chemical Name: (±)-(R,R)-N-[2-Hydroxy-5-[1-hydroxy-2-[[2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]phenyl] formamide hemifumarate
Purity: ≥99% (HPLC)
Datasheet
Citations (10)
Reviews
Literature (5)

Biological Activity

Potent, selective and long-acting β2-adrenoceptor agonist. Displays 330-fold selectivity for β2 over β1 receptors (pKd values are 8.12 and 5.58 respectively). Potently relaxes guinea pig trachea (pD2 = 9.29), and is longer-acting and 100-fold more potent than salbutamol.

Compound Libraries

Formoterol hemifumarate is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 402.45
Formula C19H24N2O4.½C4H4O4
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 43229-80-7
PubChem ID 9832292
InChI Key OBRNDARFFFHCGE-PERKLWIXSA-N
Smiles [H]OC(=O)\C=C\C(=O)O[H].COC1=CC=C(C=C1)C[C@H](C)NC[C@@H](O)C1=CC(NC([H])=O)=C(O)C=C1.COC1=CC=C(C=C1)C[C@H](C)NC[C@@H](O)C1=CC(NC([H])=O)=C(O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 50

Preparing Stock Solutions

The following data is based on the product molecular weight 402.45. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 4.97 mL 24.85 mL 49.7 mL
2.5 mM 0.99 mL 4.97 mL 9.94 mL
5 mM 0.5 mL 2.48 mL 4.97 mL
25 mM 0.1 mL 0.5 mL 0.99 mL

Molarity Calculator

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Anderson (1993) Formoterol: pharmacology, molecular basis of agonism, and mechanism of long duration of a highly potent and selective β2-adrenoceptor agonist bronchodilator. Life Sci. 52 2145 PMID: 8099696

Decker et al (1982) Effects of N-aralkyl substitution of β-agonists on α- and β-adrenoceptor subtypes: pharmacological studies and binding assays. J.Pharm.Pharmacol. 34 107 PMID: 6121868

Naline et al (1994) Relaxant effects and durations of action of formo. and salme. on the isolated human bronchus. Eur.Respir.J. 7 914 PMID: 7914176


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10 Citations for Formoterol hemifumarate

Citations are publications that use Tocris products. Selected citations for Formoterol hemifumarate include:

Pon et al (2016) The β2-adrenoceptor activates a positive cAMP-calcium feedforward loop to drive breast cancer cell invasion. FASEB J 30 1144 PMID: 26578688

Bacou (2017) β2-adrenoreceptor stimulation dampens the LPS-induced M1 polarization in pig macrophages. Dev Comp Immunol 76 169 PMID: 28633932

Plummer et al (2004) Expression of inwardly rectifying potassium channels (GIRKs) and beta-adrenergic regulation of breast cancer cell lines. BMC Cancer 4 93 PMID: 15603589

Koziczak-Holbro et al (2019) Pharmacological Characterization of a Novel 5-Hydroxybenzothiazolone-Derived β2-Adrenoceptor Agonist with Functional Selectivity for Anabolic Effects on Skeletal Muscle Resulting in a Wider Cardiovascular Safety Window in Preclinical Studies. J Pharmacol Exp Ther 369 188 PMID: 30819762


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