Formoterol hemifumarate

Pricing Availability   Qty
Description: Potent and selective β2 agonist
Alternative Names: BD 40A
Chemical Name: (±)-(R,R)-N-[2-Hydroxy-5-[1-hydroxy-2-[[2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]phenyl] formamide hemifumarate
Purity: ≥99% (HPLC)
Citations (10)
Literature (1)

Biological Activity for Formoterol hemifumarate

Formoterol hemifumarate is a potent, selective and long-acting β2-adrenoceptor agonist. Displays 330-fold selectivity for β2 over β1 receptors (pKd values are 8.12 and 5.58 respectively). Potently relaxes guinea pig trachea (pD2 = 9.29), and is longer-acting and 100-fold more potent than Salbutamol (Cat. No. 0634).

Compound Libraries for Formoterol hemifumarate

Formoterol hemifumarate is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Formoterol hemifumarate

M. Wt 402.45
Formula C19H24N2O4.½C4H4O4
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 43229-80-7
PubChem ID 9832292
Smiles [H]OC(=O)\C=C\C(=O)O[H].COC1=CC=C(C=C1)C[C@H](C)NC[C@@H](O)C1=CC(NC([H])=O)=C(O)C=C1.COC1=CC=C(C=C1)C[C@H](C)NC[C@@H](O)C1=CC(NC([H])=O)=C(O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Formoterol hemifumarate

Solvent Max Conc. mg/mL Max Conc. mM

Preparing Stock Solutions for Formoterol hemifumarate

The following data is based on the product molecular weight 402.45. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 4.97 mL 24.85 mL 49.7 mL
2.5 mM 0.99 mL 4.97 mL 9.94 mL
5 mM 0.5 mL 2.48 mL 4.97 mL
25 mM 0.1 mL 0.5 mL 0.99 mL

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Product Datasheets for Formoterol hemifumarate

Certificate of Analysis / Product Datasheet
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References for Formoterol hemifumarate

References are publications that support the biological activity of the product.

Anderson (1993) Formoterol: pharmacology, molecular basis of agonism, and mechanism of long duration of a highly potent and selective β2-adrenoceptor agonist bronchodilator. Life Sci. 52 2145 PMID: 8099696

Decker et al (1982) Effects of N-aralkyl substitution of β-agonists on α- and β-adrenoceptor subtypes: pharmacological studies and binding assays. J.Pharm.Pharmacol. 34 107 PMID: 6121868

Naline et al (1994) Relaxant effects and durations of action of formo. and salme. on the isolated human bronchus. Eur.Respir.J. 7 914 PMID: 7914176

If you know of a relevant reference for Formoterol hemifumarate, please let us know.

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10 Citations for Formoterol hemifumarate

Citations are publications that use Tocris products. Selected citations for Formoterol hemifumarate include:

Bacou (2017) β2-adrenoreceptor stimulation dampens the LPS-induced M1 polarization in pig macrophages. Dev Comp Immunol 76 169 PMID: 28633932

Maupoil et al (2007) Ectopic activity in the rat pulmonary vein can arise from simultaneous activation of alpha1- and beta1-adrenoceptors. Br J Pharmacol 150 899 PMID: 17325650

Lavine et al (2013) Attenuation of choroidal neovascularization by β(2)-adrenoreceptor antagonism. JAMA Ophthalmol 131 376 PMID: 23303344

Pon et al (2016) The β2-adrenoceptor activates a positive cAMP-calcium feedforward loop to drive breast cancer cell invasion. FASEB J 30 1144 PMID: 26578688

Do you know of a great paper that uses Formoterol hemifumarate from Tocris? Please let us know.

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Literature in this Area

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