Salmeterol xinafoate

Pricing Availability Delivery Time Qty
Cat.No. 4712 - Salmeterol xinafoate | C25H37NO4.C11H8O3 | CAS No. 94749-08-3
Description: Long-acting β2 agonist; bronchodilator
Chemical Name: 4-Hydroxy-α1-[[[6-(4-phenylbutoxy)hexyl]amino]methyl]-1,3-benzenedimethanol 1-hydroxy-2-naphthalenecarboxylic acid salt
Purity: ≥99% (HPLC)
Datasheet
Citations (4)
Literature

Biological Activity

Long-acting β2 adrenergic receptor agonist. Inhibits the release of histamine, leukotrienes and prostaglandin D2, and blocks GM-CSF production from human cultured mast cells. Exhibits efficacious bronchodilatory activity in patients with asthma or chronic obstructive pulmonary disease (COPD).

Compound Libraries

Salmeterol xinafoate is also offered as part of the Tocriscreen Plus and Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 603.75
Formula C25H37NO4.C11H8O3
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 94749-08-3
PubChem ID 56801
InChI Key XTZNCVSCVHTPAI-UHFFFAOYSA-N
Smiles OC(C2=CC(CO)=C(O)C=C2)CNCCCCCCOCCCCC1=CC=CC=C1.OC4=C(C(O)=O)C=CC3=CC=CC=C34

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 60.37 100
ethanol 12.07 20

Preparing Stock Solutions

The following data is based on the product molecular weight 603.75. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.66 mL 8.28 mL 16.56 mL
5 mM 0.33 mL 1.66 mL 3.31 mL
10 mM 0.17 mL 0.83 mL 1.66 mL
50 mM 0.03 mL 0.17 mL 0.33 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Akabane et al (2006) Effects of salmeterol xinafoate and fluticasone propionate on immunological activation of human cultured mast cells. Allergol.Int. 55 387 PMID: 17130681

Rennard et al (2001) Use of a long-acting inhaled beta2-adrenergic agonist, salmeterol xinafoate, in patients with chronic obstructive pulmonary disease. Am.J.Respir.Crit.Care Med. 163 1087 PMID: 11316640

Roberts et al (1999) The long-acting beta2-agonist salmeterol xinafoate: effects on airway inflammation in asthma. Eur.Respir.J. 14 275 PMID: 10515401


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View all Adrenergic β2 Receptor Agonists

Keywords: long acting beta2 b2 β2 adrenergics adrenoceptors agonists LABAs asthma COPD respiratory disease bronchodilators Adrenergic Beta-2 Receptors

4 Citations for Salmeterol xinafoate

Citations are publications that use Tocris products. Selected citations for Salmeterol xinafoate include:

Israël-Assayag et al (2015) ASM-024, a piperazinium compound, promotes the in vitro relaxation of β2-adrenoreceptor desensitized tracheas. Nat Commun 10 e0120095 PMID: 25799096

Sykes and Charlton (2012) Slow receptor dissociation is not a key factor in the duration of action of inhaled long-acting β2-adrenoceptor agonists. Br J Pharmacol 165 2672 PMID: 21883146

Rankovic et al (2011) Modulation of calcium-dependent inactivation of L-type Ca2+ channels via β-adrenergic signaling in thalamocortical relay neurons. PLoS One 6 e27474 PMID: 22164209

Scola et al (2009) The long-acting beta-adrenoceptor agonist, indacaterol, inhibits IgE-dependent responses of human lung mast cells. Br J Pharmacol 158 267 PMID: 19371332


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Pathways for Salmeterol xinafoate

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