Salbutamol hemisulfate

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Cat.No. 0634 - Salbutamol hemisulfate | C13H21NO3.1/2H2SO4 | CAS No. 51022-70-9
Description: β agonist (β2 > β1)
Chemical Name: α1-[[(1,1-Dimethylethyl)amino]methyl]-4-hydroxy-1,3-benzenedimethanol hemisulfate
Purity: ≥99% (HPLC)
Datasheet
Citations (5)
Reviews
Literature (5)

Biological Activity

Non-selective β-adrenergic agonist, more potent at β2 than β1 receptors.

Technical Data

M. Wt 288.35
Formula C13H21NO3.1/2H2SO4
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 51022-70-9
PubChem ID 39859
InChI Key BNPSSFBOAGDEEL-UHFFFAOYSA-N
Smiles OS(O)(=O)=O.CC(C)(C)NCC(O)C1=CC=C(O)C(CO)=C1.CC(C)(C)NCC(O)C1=CC=C(O)C(CO)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 28.84 100

Preparing Stock Solutions

The following data is based on the product molecular weight 288.35. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.47 mL 17.34 mL 34.68 mL
5 mM 0.69 mL 3.47 mL 6.94 mL
10 mM 0.35 mL 1.73 mL 3.47 mL
50 mM 0.07 mL 0.35 mL 0.69 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

January et al (1998) Salmeterol-induced desensitisation, internalization and phosphorylation of the human β2-adrenoceptor. Br.J.Pharmacol. 123 701 PMID: 9517390

Prior et al (1998) Effects of the enantiomers of R,S-salbutamol on incompletely fused tetanic contractions of slow- and fast-twitch skeletal muscles of the guinea-pig. Br.J.Pharmacol. 123 558 PMID: 9504397

Strosberg and Pietri-Rouxel (1996) Function and regulation of the β3-adrenoceptor. TiPS 17 373 PMID: 8979772

Merck Index 12 217


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Keywords: Salbutamol hemisulfate, Salbutamol hemisulfate supplier, β-adrenoceptor, beta-adrenoceptor, b-adrenoceptor, agonists, β-adrenergic, beta-adrenergic, b-adrenergic, Receptors, albuterol, Adrenergic, Beta-2, 0634, Tocris Bioscience

5 Citations for Salbutamol hemisulfate

Citations are publications that use Tocris products. Selected citations for Salbutamol hemisulfate include:

Namkung et al (2016) Monitoring G protein-coupled receptor and [beta]-arrestin trafficking in live cells using enhanced bystander BRET Nature Communications 7 12178 PMID: 27397672

Sykes and Charlton (2012) Slow receptor dissociation is not a key factor in the duration of action of inhaled long-acting β2-adrenoceptor agonists. Br J Pharmacol 165 2672 PMID: 21883146

Picard et al (2018) Bioluminescence resonance energy transfer-based biosensors allow monitoring of ligand- and transducer-mediated GPCR conformational changes. Commun Biol 1 106 PMID: 30271986

Pon et al (2016) The β2-adrenoceptor activates a positive cAMP-calcium feedforward loop to drive breast cancer cell invasion. FASEB J 30 1144 PMID: 26578688

Zaytseva et al (2013) Resonant waveguide grating biosensor-enabled label-free and fluorescence detection of cell adhesion. Sens Actuators B Chem 188 PMID: 24319319


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