Salbutamol hemisulfate

Pricing Availability   Qty
Description: β2-adrenoceptor agonist
Alternative Names: Albuterol
Chemical Name: α1-[[(1,1-Dimethylethyl)amino]methyl]-4-hydroxy-1,3-benzenedimethanol hemisulfate
Purity: ≥98% (HPLC)
Citations (6)
Literature (1)

Biological Activity for Salbutamol hemisulfate

Salbutamol hemisulfate is a selective β2-adrenergic agonist with 29-fold higher selectivity for β2 over β1 receptors. Salbutamol elevates fibroblast growth factor 20 (FGF20) in nigrostriatal neurons, and is neuroprotective in a mouse model of Parkinson's disease.

Technical Data for Salbutamol hemisulfate

M. Wt 288.35
Formula C13H21NO3.½H2SO4
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 51022-70-9
PubChem ID 39859
Smiles OS(O)(=O)=O.CC(C)(C)NCC(O)C1=CC=C(O)C(CO)=C1.CC(C)(C)NCC(O)C1=CC=C(O)C(CO)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Salbutamol hemisulfate

Solvent Max Conc. mg/mL Max Conc. mM
water 28.84 100

Preparing Stock Solutions for Salbutamol hemisulfate

The following data is based on the product molecular weight 288.35. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.47 mL 17.34 mL 34.68 mL
5 mM 0.69 mL 3.47 mL 6.94 mL
10 mM 0.35 mL 1.73 mL 3.47 mL
50 mM 0.07 mL 0.35 mL 0.69 mL

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Product Datasheets for Salbutamol hemisulfate

Certificate of Analysis / Product Datasheet
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References for Salbutamol hemisulfate

References are publications that support the biological activity of the product.

January et al (1998) Salmeterol-induced desensitisation, internalization and phosphorylation of the human β2-adrenoceptor. Br.J.Pharmacol. 123 701 PMID: 9517390

Prior et al (1998) Effects of the enantiomers of R,S-salbutamol on incompletely fused tetanic contractions of slow- and fast-twitch skeletal muscles of the guinea-pig. Br.J.Pharmacol. 123 558 PMID: 9504397

Strosberg and Pietri-Rouxel (1996) Function and regulation of the β3-adrenoceptor. TiPS 17 373 PMID: 8979772

Merck Index 12 217

Fletcher et al (2019) Targeted repositioning identifies drugs that increase fibroblast growth factor 20 production and protect against 6-hydroxydopamine-induced nigral cell loss in rats. Sci.Rep. 9 PMID: 31171821

Baker (2005) The selectivity of beta-adrenoceptor antagonists at the human β1, β2 and β3 adrenoceptors. Br.J.Pharmacol. 144 317 PMID: 15655528

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6 Citations for Salbutamol hemisulfate

Citations are publications that use Tocris products. Selected citations for Salbutamol hemisulfate include:

Picard et al (2018) Bioluminescence resonance energy transfer-based biosensors allow monitoring of ligand- and transducer-mediated GPCR conformational changes. Commun Biol 1 106 PMID: 30271986

Namkung et al (2016) Monitoring G protein-coupled receptor and [beta]-arrestin trafficking in live cells using enhanced bystander BRET Nature Communications 7 12178 PMID: 27397672

Zaytseva et al (2013) Resonant waveguide grating biosensor-enabled label-free and fluorescence detection of cell adhesion. Sens Actuators B Chem 188 PMID: 24319319

Pon et al (2016) The β2-adrenoceptor activates a positive cAMP-calcium feedforward loop to drive breast cancer cell invasion. FASEB J 30 1144 PMID: 26578688

Do you know of a great paper that uses Salbutamol hemisulfate from Tocris? Please let us know.

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Literature in this Area

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Depression Poster

Depression Poster

Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.