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Biological Activity for Salbutamol hemisulfate
Salbutamol hemisulfate is a selective β2-adrenergic agonist with 29-fold higher selectivity for β2 over β1 receptors. Salbutamol elevates fibroblast growth factor 20 (FGF20) in nigrostriatal neurons, and is neuroprotective in a mouse model of Parkinson's disease.
Technical Data for Salbutamol hemisulfate
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Salbutamol hemisulfate
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for Salbutamol hemisulfate
The following data is based on the product molecular weight 288.35. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.47 mL||17.34 mL||34.68 mL|
|5 mM||0.69 mL||3.47 mL||6.94 mL|
|10 mM||0.35 mL||1.73 mL||3.47 mL|
|50 mM||0.07 mL||0.35 mL||0.69 mL|
Product Datasheets for Salbutamol hemisulfate
References for Salbutamol hemisulfate
References are publications that support the biological activity of the product.
January et al (1998) Salmeterol-induced desensitisation, internalization and phosphorylation of the human β2-adrenoceptor. Br.J.Pharmacol. 123 701 PMID: 9517390
Prior et al (1998) Effects of the enantiomers of R,S-salbutamol on incompletely fused tetanic contractions of slow- and fast-twitch skeletal muscles of the guinea-pig. Br.J.Pharmacol. 123 558 PMID: 9504397
Strosberg and Pietri-Rouxel (1996) Function and regulation of the β3-adrenoceptor. TiPS 17 373 PMID: 8979772
Merck Index 12 217
Fletcher et al (2019) Targeted repositioning identifies drugs that increase fibroblast growth factor 20 production and protect against 6-hydroxydopamine-induced nigral cell loss in rats. Sci.Rep. 9 PMID: 31171821
Baker (2005) The selectivity of beta-adrenoceptor antagonists at the human β1, β2 and β3 adrenoceptors. Br.J.Pharmacol. 144 317 PMID: 15655528
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Keywords: Salbutamol hemisulfate, Salbutamol hemisulfate supplier, β-adrenoceptor, beta-adrenoceptor, b-adrenoceptor, agonists, β-adrenergic, beta-adrenergic, b-adrenergic, receptors, albuterol, beta2, b2, parkinsons, Albuterol, Adrenergic, Beta-2, Receptors, 0634, Tocris Bioscience
6 Citations for Salbutamol hemisulfate
Citations are publications that use Tocris products. Selected citations for Salbutamol hemisulfate include:
Sykes and Charlton (2012) Slow receptor dissociation is not a key factor in the duration of action of inhaled long-acting β2-adrenoceptor agonists. Br J Pharmacol 165 2672 PMID: 21883146
Pon et al (2016) The β2-adrenoceptor activates a positive cAMP-calcium feedforward loop to drive breast cancer cell invasion. FASEB J 30 1144 PMID: 26578688
Zaytseva et al (2013) Resonant waveguide grating biosensor-enabled label-free and fluorescence detection of cell adhesion. Sens Actuators B Chem 188 PMID: 24319319
Baker (2005) The selectivity of beta-adrenoceptor antagonists at the human beta1, beta2 and beta3 adrenoceptors. Br.J.Pharmacol. 144 317 PMID: 1565552
Namkung et al (2016) Monitoring G protein-coupled receptor and [beta]-arrestin trafficking in live cells using enhanced bystander BRET Nature Communications 7 12178 PMID: 27397672
Picard et al (2018) Bioluminescence resonance energy transfer-based biosensors allow monitoring of ligand- and transducer-mediated GPCR conformational changes. Commun Biol 1 106 PMID: 30271986
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.