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Non-selective β-adrenergic agonist, more potent at β2 than β1 receptors.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 288.35. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.47 mL||17.34 mL||34.68 mL|
|5 mM||0.69 mL||3.47 mL||6.94 mL|
|10 mM||0.35 mL||1.73 mL||3.47 mL|
|50 mM||0.07 mL||0.35 mL||0.69 mL|
References are publications that support the biological activity of the product.
January et al (1998) Salmeterol-induced desensitisation, internalization and phosphorylation of the human β2-adrenoceptor. Br.J.Pharmacol. 123 701 PMID: 9517390
Prior et al (1998) Effects of the enantiomers of R,S-salbutamol on incompletely fused tetanic contractions of slow- and fast-twitch skeletal muscles of the guinea-pig. Br.J.Pharmacol. 123 558 PMID: 9504397
Strosberg and Pietri-Rouxel (1996) Function and regulation of the β3-adrenoceptor. TiPS 17 373 PMID: 8979772
Merck Index 12 217
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5 Citations for Salbutamol hemisulfate
Citations are publications that use Tocris products. Selected citations for Salbutamol hemisulfate include:
Namkung et al (2016) Monitoring G protein-coupled receptor and [beta]-arrestin trafficking in live cells using enhanced bystander BRET Nature Communications 7 12178 PMID: 27397672
Sykes and Charlton (2012) Slow receptor dissociation is not a key factor in the duration of action of inhaled long-acting β2-adrenoceptor agonists. Br J Pharmacol 165 2672 PMID: 21883146
Picard et al (2018) Bioluminescence resonance energy transfer-based biosensors allow monitoring of ligand- and transducer-mediated GPCR conformational changes. Commun Biol 1 106 PMID: 30271986
Pon et al (2016) The β2-adrenoceptor activates a positive cAMP-calcium feedforward loop to drive breast cancer cell invasion. FASEB J 30 1144 PMID: 26578688
Zaytseva et al (2013) Resonant waveguide grating biosensor-enabled label-free and fluorescence detection of cell adhesion. Sens Actuators B Chem 188 PMID: 24319319
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Literature in this Area
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Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.