Metoprolol tartrate

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Cat.No. 3256 - Metoprolol tartrate | C15H25NO3.½C4H6O6 | CAS No. 56392-17-7
Description: Selective β1 antagonist
Chemical Name: 1-[4-(2-Methoxyethyl)phenoxy]-3-[(1-methylethyl)amino]-2-propanol hemitartrate
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Selective β1-adrenoceptor antagonist (Ki values are 47, 2960 and 10100 nM for β1, β2 and β3 adrenoceptors respectively). Inhibits spontaneous endothelin-1 production in vitro and displays antihypertensive and antianginal activity in vivo.

Compound Libraries

Metoprolol tartrate is also offered as part of the Tocriscreen Plus and Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 342.4
Formula C15H25NO3.½C4H6O6
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 56392-17-7
PubChem ID 6420057
InChI Key YGULWPYYGQCFMP-UHFFFAOYSA-N
Smiles O=C(O)C(O)C(O)C(O)=O.OC(CNC(C)C)COC1=CC=C(CCOC)C=C1.OC(CNC(C)C)COC2=CC=C(CCOC)C=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 34.24 100
water 34.24 100

Preparing Stock Solutions

The following data is based on the product molecular weight 342.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.92 mL 14.6 mL 29.21 mL
5 mM 0.58 mL 2.92 mL 5.84 mL
10 mM 0.29 mL 1.46 mL 2.92 mL
50 mM 0.06 mL 0.29 mL 0.58 mL

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Reconstitution Calculator

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Garlichs et al (1999) Beta-blockers reduce the release and synthesis of endothelin-1 in human endothelial cells. Eur.J.Clin.Invest. 29 12 PMID: 10092983

Dasbiswas et al (2008) S-metoprolol: The 2008 Clinical Review. J.Indian.Med.Assoc. 106 259 PMID: 18828349

Hoffmann et al (2004) Comparative pharmacology of human β-adrenergic receptor subtypes - characterization of stably transfected receptors in CHO cells. Naunyn-Schmied.Arch.Pharmacol. 369 151 PMID:


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Citations for Metoprolol tartrate

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Literature in this Area

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Pathways for Metoprolol tartrate

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