Xamoterol hemifumarate

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Cat.No. 0950 - Xamoterol hemifumarate | C16H25N3O5.0.5C4H4O4 | CAS No. 73210-73-8
Description: Selective β1 partial agonist
Alternative Names: ICI 118,587
Chemical Name: 1-(4-Hydroxyphenoxy)-3-[2-(4-morpholinocarboxamido)ethylamino]-2-propanol hemifumarate
Purity: ≥97% (HPLC)
Datasheet
Citations (10)
Reviews
Literature (4)

Biological Activity

β1-adrenoceptor-selective partial agonist (pA2 values are 7.4 - 7.8 and 5.2 - 6.2 at β1- and β2-adrenoceptors respectively).

Licensing Information

Sold with the permission of AstraZeneca UK Ltd.

Compound Libraries

Xamoterol hemifumarate is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 397.43
Formula C16H25N3O5.0.5C4H4O4
Storage Store at RT
Purity ≥97% (HPLC)
CAS Number 73210-73-8
PubChem ID 6440459
InChI Key QEDVGROSOZBGOZ-WXXKFALUSA-N
Smiles [H]OC(=O)\C=C\C(=O)O[H].OC(CNCCNC(=O)N1CCOCC1)COC1=CC=C(O)C=C1.OC(CNCCNC(=O)N1CCOCC1)COC1=CC=C(O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble to 50 mM in water and to 100 mM in DMSO

Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Barlow et al (1981) β-Adrenoceptor stimulant properties of aminoalkylamino-substituted 1-aryl-2-ethanols and 1-(aryloxy)-2-propanols. J.Med.Chem. 24 315 PMID: 6115058

Malta et al (1985) The in vitro pharmacology of xamoterol (ICI 118,587). Br.J.Pharmacol. 85 179 PMID: 2862938

Nuttall and Snow (1982) The cardiovascular effects of ICI 118,587: a β1-adrenoceptor partial agonist. Br.J.Pharmacol. 77 381 PMID: 6128041


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10 Citations for Xamoterol hemifumarate

Citations are publications that use Tocris products. Selected citations for Xamoterol hemifumarate include:

Lavine (2017) β2-Adrenergic Receptor Antagonism Attenuates CNV Through Inhibition of VEGF and IL-6 Expression. Invest Ophthalmol Vis Sci 58 299 PMID: 28114591

Zhi et al (2019) Adrenergic modulation of AMPK-dependent autophagy by chronic stress enhances cell proliferation and survival in gastric cancer. Int J Oncol 54 1625 PMID: 30896863

Steinle et al (2003) β 3-adrenergic receptors regulate retinal endothelial cell migration and proliferation. PLoS One 278 20681 PMID: 12670949

Creed et al (2015) β2-adrenoceptor signaling regulates invadopodia formation to enhance tumor cell invasion. Breast Cancer Res 17 145 PMID: 26607426


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Literature in this Area

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