Nebivolol hydrochloride

Pricing Availability   Qty
Description: Highly selective β1-adrenoceptor antagonist
Chemical Name: (±)-[2R*(1S*5S*(S*))]-α,α'-[Iminobis(methylene)bis(6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol)
Purity: ≥98% (HPLC)
Citations (1)
Literature (1)

Biological Activity for Nebivolol hydrochloride

Nebivolol hydrochloride is a highly selective β1-adrenoceptor antagonist (Ki values are 0.88, 20, 44, 700, 1160, 2400 and 4000 nM at β1, 5-HT1A, β2, 5-HT2, α1, H1 and D2 receptors respectively). Induces vasodilation via a nitric oxide- and cGMP-dependent mechanism (EC50 = 11.36 μM in renal arteries) and displays antihypertensive activity in vivo. GRK/β -arrestin biased agonist at the β2 adrenoceptor.

Compound Libraries for Nebivolol hydrochloride

Nebivolol hydrochloride is also offered as part of the Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Nebivolol hydrochloride

M. Wt 441.9
Formula C22H25F2NO4.HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 152520-56-4
PubChem ID 11812257
Smiles FC(C=C4)=CC3=C4O[C@@](CC3)([H])[C@H](O)CNC[C@@H](O)[C@]2([H])CCC1=CC(F)=CC=C1O2.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Nebivolol hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 44.19 100
ethanol 4.42 10

Preparing Stock Solutions for Nebivolol hydrochloride

The following data is based on the product molecular weight 441.9. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.26 mL 11.31 mL 22.63 mL
5 mM 0.45 mL 2.26 mL 4.53 mL
10 mM 0.23 mL 1.13 mL 2.26 mL
50 mM 0.05 mL 0.23 mL 0.45 mL

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Product Datasheets for Nebivolol hydrochloride

References for Nebivolol hydrochloride

References are publications that support the biological activity of the product.

Pauwels et al (1988) The receptor binding profile of the new antihypertensive agent nebi. and its stereoisomers compared with various β-adrenergic blockers. Mol.Pharmacol. 34 843 PMID: 2462161

Georgescu et al (2008) Nebivolol induces a hyperpolarizing effect on smooth muscle cells in the mouse renal artery by activation of beta-2-adrenoceptors. Pharmacology 81 110 PMID: 17952013

Erickson et al (2013) The beta -blocker nebi. Is a GRK/ beta -arrestin biased agonist. PLoS One 8 e71980 PMID: 23977191

If you know of a relevant reference for Nebivolol hydrochloride, please let us know.

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1 Citation for Nebivolol hydrochloride

Citations are publications that use Tocris products. Selected citations for Nebivolol hydrochloride include:

Littmann et al (2015) Recruitment of β-arrestin 1 and 2 to the β2-adrenoceptor: analysis of 65 ligands. Brain Res 355 183 PMID: 26306764

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Depression Poster

Depression Poster

Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.