SQ 22536

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Cat.No. 1435 - SQ 22536 | C9H11N5O | CAS No. 17318-31-9
Description: Adenylyl cyclase inhibitor
Chemical Name: 9-(Tetrahydro-2-furanyl)-9H-purin-6-amine
Purity: ≥99% (HPLC)
Datasheet
Citations (11)
Reviews
Literature

Biological Activity

Inhibitor of adenylyl cyclase (IC50 = 1.4 μM). Inhibits PGE1-stimulated increases in cAMP levels in intact human platelets. Cell permeable.

Compound Libraries

SQ 22536 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 205.22
Formula C9H11N5O
Storage Desiccate at +4°C
Purity ≥99% (HPLC)
CAS Number 17318-31-9
PubChem ID 5270
InChI Key UKHMZCMKHPHFOT-UHFFFAOYSA-N
Smiles NC1=C2N=CN(C3CCCO3)C2=NC=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 10.26 50

Preparing Stock Solutions

The following data is based on the product molecular weight 205.22. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 9.75 mL 48.73 mL 97.46 mL
2.5 mM 1.95 mL 9.75 mL 19.49 mL
5 mM 0.97 mL 4.87 mL 9.75 mL
25 mM 0.19 mL 0.97 mL 1.95 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Fabbri et al (1991) Inhibition of adenylate cyclase of catfish and rat hepatocyte membranes by 9-(tetrahydro-2-furyl)adenine (SQ 22536). J.Enzyme Inhib. 5 87 PMID: 1669444

Harris et al (1979) Inhibition of adenylate cyclase in human blood platelets by 9-substituted adenine derivatives. J.Cyclic Nucleotide Res. 5 125 PMID: 221552

Hourani et al (2001) Role of cyclic nucleotides in vasodilations of the rat thoracic aorta induced by adenosine analogues. Br.J.Pharmacol. 133 833 PMID: 11454656

Mei et al (2014) Micropillar arrays as a high-throughput screening platform for therapeutics in multiple sclerosis. Nat.Methods. 20 954 PMID: 24997607

Madhavan et al (2018) Induction of myelinating oligodendrocytes in human cortical spheroids. Nat.Methods. PMID: 30046099


If you know of a relevant reference for SQ 22536, please let us know.

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View all Adenylyl Cyclase Inhibitors

Keywords: SQ 22536, SQ 22536 supplier, Adenylyl, cyclase, inhibitors, inhibits, Cyclases, adenylate, SQ22536, Cyclase, 1435, Tocris Bioscience

11 Citations for SQ 22536

Citations are publications that use Tocris products. Selected citations for SQ 22536 include:

Luo (2017) β2-adrenoreceptor Inverse Agonist Down-regulates Muscarine Cholinergic Subtype-3 Receptor and Its Downstream Signal Pathways in Airway Smooth Muscle Cells in vitro. Scientific Reports 7 39905 PMID: 28051147

Olesen et al (2016) The Vasopressin Type-2 Receptor and Prostaglandin Receptors EP2 and EP4 can Increase Aquaporin-2 Plasma Membrane Targeting Through a cAMP Independent Pathway. American Journal of Physiology - Renal Physiology 311 F935 PMID: 27558562

Babu et al (2012) Genistein prevents hyperglycemia-induced monocyte adhesion to human aortic endothelial cells through preservation of the cAMP signaling pathway and ameliorates vascular inflammation in obese diabetic mice. J Nutr 142 724 PMID: 22399524

Liu et al (2016) Inhibition of lysyl oxidase by prostaglandin E2 via EP2/EP4 receptors in human amnion fibroblasts: Implications for parturition. Mol Cell Endocrinol 424 118 PMID: 26826430

Wang et al (2015) Phosphorylation of STAT3 mediates the induction of cyclooxygenase-2 by cortisol in the human amnion at parturition. Sci.Signal. 8 PMID: 26508788

Du et al (2015) Adrenergic and serotonin receptors affect retinal superoxide generation in diabetic mice: relationship to capillary degeneration and permeability. FASEB J 29 2194 PMID: 25667222

Morris et al (2009) C5a mediates peripheral blood neutrophil dysfunction in critically ill patients. Am J Respir Crit Care Med 180 19 PMID: 19324972

Bhanu et al (2008) Inhibition of erythroblast growth and fetal hemoglobin production by ribofuranose-substituted adenosine derivatives. PLoS One 1782 504 PMID: 18586086

Tao et al (2013) cAMP level modulates scleral collagen remodeling, a critical step in the development of myopia. Biochim Biophys Acta 8 e71441 PMID: 23951163

Meitzen et al (2011) β1-Adrenergic receptors activate two distinct signaling pathways in striatal neurons. J Neurochem 116 984 PMID: 21143600

Tang et al (2014) Lactate-mediated glia-neuronal signalling in the mammalian brain. Nat Commun 5 3284 PMID: 24518663


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Literature in this Area

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