Selective soluble adenylyl cyclase (sAC) inhibitor (IC50 = 3 - 10 μM in vivo). Inert towards transmembrane adenylyl cyclase (tmAC) in vitro and in whole cells at concentrations up to 300 μM. Blocks synthesis of cAMP and displays an antiapoptotic effect at concentrations of 1 - 100 μM.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 419.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.38 mL||11.92 mL||23.85 mL|
|5 mM||0.48 mL||2.38 mL||4.77 mL|
|10 mM||0.24 mL||1.19 mL||2.38 mL|
|50 mM||0.05 mL||0.24 mL||0.48 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Kumar et al (2009) Soluble adenylyl cyclase controls mitochondria-dependent apoptosis in coronary endothelial cells. J.Biol.Chem. 284 14760 PMID: 19336406
Stessin et al (2006) Soluble adenylyl cyclase mediates nerve growth factor-induced activation of Rap1. J.Biol.Chem. 281 17253 PMID: 16627466
If you know of a relevant reference for KH 7, please let us know.
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Keywords: selective adenylyl cyclases inhibitors inhibits soluble sAC KH7 Adenylyl Cyclase
3 Citations for KH 7
Citations are publications that use Tocris products. Selected citations for KH 7 include:
Lee et al (2012) The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP. Nature 492 123 PMID: 23143333
Jahchan et al (2013) A drug repositioning approach identifies tricyclic antidepressants as inhibitors of small cell lung cancer and other neuroendocrine tumors. Cancer Discov 3 1364 PMID: 24078773
Chen et al (2013) Resveratrol attenuates vascular endothelial inflammation by inducing autophagy through the cAMP signaling pathway. Mediators Inflamm 9 2033 PMID: 24145604
Do you know of a great paper that uses KH 7 from Tocris? If so please let us know.