ST 034307

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Description: Adenylyl cyclase 1 (AC1) inhibitor; analgesic and active in vivo
Chemical Name: 6-Chloro-2-(trichloromethyl)-4H-1-benzopyran-4-one
Purity: ≥98% (HPLC)
Citations (4)

Biological Activity for ST 034307

ST 034307 is an adenylyl cyclase 1 (AC1) inhibitor (IC50 = 2.3 μM). Exhibits some selectivity for AC1 over other AC isoforms, with no significant activity against AC8. Inhibits Ca2+/calmodulin-stimulated cAMP accumulation in hippocampal homogenates. Enhances μ opioid receptor (MOR)-mediated inhibition of AC1 in cellular assays and inhibits development and maintenance of MOR-mediated sensitization of AC1. ST 034307 relieves pain without causing tolerance in mouse models of pain. Active in vivo. Analgesic.

Technical Data for ST 034307

M. Wt 297.95
Formula C10H4Cl4O2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 133406-29-8
PubChem ID 867466
Smiles ClC1=CC=C2OC(C(Cl)(Cl)Cl)=CC(C2=C1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for ST 034307

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 29.8 100
ethanol 5.96 20

Preparing Stock Solutions for ST 034307

The following data is based on the product molecular weight 297.95. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.36 mL 16.78 mL 33.56 mL
5 mM 0.67 mL 3.36 mL 6.71 mL
10 mM 0.34 mL 1.68 mL 3.36 mL
50 mM 0.07 mL 0.34 mL 0.67 mL

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References for ST 034307

References are publications that support the biological activity of the product.

Brust et al (2017) Identification of a selective small-molecule inhibitor of type 1 adenylyl cyclase activity with analgesic properties. Sci.Signal. 10 eaah5381 PMID: 28223412

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Keywords: ST 034307, ST 034307 supplier, ST034307, adenylyl, cyclase, inhibitors, inhibits, AC1, active, in, vivo, analgesic, cAMP, Adenylyl, Cyclase, 6271, Tocris Bioscience

4 Citations for ST 034307

Citations are publications that use Tocris products. Selected citations for ST 034307 include:

Bose et al (2021) Cross-talk between cAMP and Ca2+ signalling in cardiac pacemaker cells involves IP3-evoked Ca2+ release and stimulation of adenylyl cyclase 1. BioRXiv - not yet peer reviewed

Cheng et al (2019) Antinociceptive effects of the adenylyl cyclase inhibitor ST034307 on tooth-movement-induced nociception in rats. Arch Oral Biol. 98 81 PMID: 30465937

Val J et al (2022) Reduced activity of adenylyl cyclase 1 attenuates morphine induced hyperalgesia and inflammatory pain in mice. Front Pharmacol 13 937741 PMID: 36120355

Giacoletti et al (2022) A selective adenylyl cyclase 1 inhibitor relieves pain without causing tolerance. Front.Pharmacol. 13 935588 PMID: 35899113

Do you know of a great paper that uses ST 034307 from Tocris? Please let us know.

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