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Submit ReviewST 034307
Description: Adenylyl cyclase 1 (AC1) inhibitor; analgesic and active in vivo
Chemical Name: 6-Chloro-2-(trichloromethyl)-4H-1-benzopyran-4-one
Purity: ≥98% (HPLC)
Biological Activity for ST 034307
ST 034307 is an adenylyl cyclase 1 (AC1) inhibitor (IC50 = 2.3 μM). Exhibits some selectivity for AC1 over other AC isoforms, with no significant activity against AC8. Inhibits Ca2+/calmodulin-stimulated cAMP accumulation in hippocampal homogenates. Enhances μ opioid receptor (MOR)-mediated inhibition of AC1 in cellular assays and inhibits development and maintenance of MOR-mediated sensitization of AC1. ST 034307 relieves pain without causing tolerance in mouse models of pain. Active in vivo. Analgesic.
Technical Data for ST 034307
| M. Wt | 297.95 |
| Formula | C10H4Cl4O2 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 133406-29-8 |
| PubChem ID | 867466 |
| InChI Key | NTDHYMSVCBGQJF-UHFFFAOYSA-N |
| Smiles | ClC1=CC=C2OC(C(Cl)(Cl)Cl)=CC(C2=C1)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for ST 034307
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 29.8 | 100 | |
| ethanol | 5.96 | 20 |
Preparing Stock Solutions for ST 034307
The following data is based on the product molecular weight 297.95. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.36 mL | 16.78 mL | 33.56 mL |
| 5 mM | 0.67 mL | 3.36 mL | 6.71 mL |
| 10 mM | 0.34 mL | 1.68 mL | 3.36 mL |
| 50 mM | 0.07 mL | 0.34 mL | 0.67 mL |
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Product Datasheets for ST 034307
References for ST 034307
References are publications that support the biological activity of the product.
Brust et al (2017) Identification of a selective small-molecule inhibitor of type 1 adenylyl cyclase activity with analgesic properties. Sci.Signal. 10 eaah5381 PMID: 28223412
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Keywords: ST 034307, ST 034307 supplier, ST034307, adenylyl, cyclase, inhibitors, inhibits, AC1, active, in, vivo, analgesic, cAMP, Adenylyl, Cyclase, 6271, Tocris Bioscience
4 Citations for ST 034307
Citations are publications that use Tocris products. Selected citations for ST 034307 include:
Bose et al (2021) Cross-talk between cAMP and Ca2+ signalling in cardiac pacemaker cells involves IP3-evoked Ca2+ release and stimulation of adenylyl cyclase 1. BioRXiv - not yet peer reviewed
Cheng et al (2019) Antinociceptive effects of the adenylyl cyclase inhibitor ST034307 on tooth-movement-induced nociception in rats. Arch Oral Biol. 98 81 PMID: 30465937
Val J et al (2022) Reduced activity of adenylyl cyclase 1 attenuates morphine induced hyperalgesia and inflammatory pain in mice. Front Pharmacol 13 937741 PMID: 36120355
Giacoletti et al (2022) A selective adenylyl cyclase 1 inhibitor relieves pain without causing tolerance. Front.Pharmacol. 13 935588 PMID: 35899113
Do you know of a great paper that uses ST 034307 from Tocris? Please let us know.
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