ST 034307

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Cat.No. 6271 - ST 034307 | C10H4Cl4O2 | CAS No. 133406-29-8
Description: Adenylyl cyclase 1 (AC1) inhibitor; analgesic and active in vivo
Chemical Name: 6-Chloro-2-(trichloromethyl)-4H-1-benzopyran-4-one
Purity: ≥98% (HPLC)

Biological Activity

Adenylyl cyclase 1 (AC1) inhibitor (IC50 = 2.3 μM). Exhibits some selectivity for AC1 over other AC isoforms, with no significant activity against AC8. Inhibits Ca2+/calmodulin-stimulated cAMP accumulation in hippocampal homogenates. Enhances μ opioid receptor (MOR)-mediated inhibition of AC1 in cellular assays and inhibits development and maintenance of MOR-mediated sensitization of AC1. Active in vivo. Analgesic.

Technical Data

M. Wt 297.95
Formula C10H4Cl4O2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 133406-29-8
PubChem ID 867466
Smiles ClC1=CC=C2OC(C(Cl)(Cl)Cl)=CC(C2=C1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 29.8 100
ethanol 5.96 20

Preparing Stock Solutions

The following data is based on the product molecular weight 297.95. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.36 mL 16.78 mL 33.56 mL
5 mM 0.67 mL 3.36 mL 6.71 mL
10 mM 0.34 mL 1.68 mL 3.36 mL
50 mM 0.07 mL 0.34 mL 0.67 mL

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References are publications that support the products' biological activity.

Brust et al (2017) Identification of a selective small-molecule inhibitor of type 1 adenylyl cyclase activity with analgesic properties. Sci.Signal. 10 eaah5381 PMID: 28223412

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