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Biological Activity for NKY 80
NKY 80 is an inhibitor of adenylyl cyclase (AC). Exhibits greater affinity for AC5 over AC3 and AC2 (IC50 values are 8.3 μM, 132 μM and 1.7 mM respectively).
Compound Libraries for NKY 80
Technical Data for NKY 80
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for NKY 80
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|ethanol||2.29||10 with gentle warming|
Preparing Stock Solutions for NKY 80
The following data is based on the product molecular weight 229.23. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||4.36 mL||21.81 mL||43.62 mL|
|5 mM||0.87 mL||4.36 mL||8.72 mL|
|10 mM||0.44 mL||2.18 mL||4.36 mL|
|50 mM||0.09 mL||0.44 mL||0.87 mL|
References for NKY 80
References are publications that support the biological activity of the product.
Onda et al (2001) Type-specific regulation regulation of adenylyl cyclase. Selective pharmacological stimulation and inhibition of adenylyl cyclase isoforms. J.Biol.Chem. 276 47785 PMID: 11602596
Pierre et al (2009) Capturing adenylyl cyclases as potential drug targets. Nat.Rev.Drug Discov. 8 321 PMID: 19337273
If you know of a relevant reference for NKY 80, please let us know.
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Keywords: NKY 80, NKY 80 supplier, NKY80, adenylyl, cyclase, adenylate, inhibitors, inhibits, Adenylyl, Cyclase, 5071, Tocris Bioscience
1 Citation for NKY 80
Citations are publications that use Tocris products. Selected citations for NKY 80 include:
Jun et al (2020) In Vivo Imaging of the Coupling between Neuronal and CREB Activity in the Mouse Brain. Neuron 105 799-812.e5 PMID: 31883788
Do you know of a great paper that uses NKY 80 from Tocris? Please let us know.
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