NKY 80

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Cat.No. 5071 - NKY 80 | C12H11N3O2 | CAS No. 299442-43-6
Description: Adenylyl cyclase inhibitor
Chemical Name: 2-Amino-7-(2-furanyl)-7,8-dihydro-5(6H)-quinazolinone
Purity: ≥98% (HPLC)
Literature (1)

Biological Activity

Inhibitor of adenylyl cyclase (AC). Exhibits greater affinity for AC5 over AC3 and AC2 (IC50 values are 8.3 μM, 132 μM and 1.7 mM respectively).

Compound Libraries

NKY 80 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 229.23
Formula C12H11N3O2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 299442-43-6
PubChem ID 2772368
Smiles NC(N=C2)=NC1=C2C(CC(C3=CC=CO3)C1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 22.92 100
ethanol 2.29 10 with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 229.23. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.36 mL 21.81 mL 43.62 mL
5 mM 0.87 mL 4.36 mL 8.72 mL
10 mM 0.44 mL 2.18 mL 4.36 mL
50 mM 0.09 mL 0.44 mL 0.87 mL

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References are publications that support the biological activity of the product.

Onda et al (2001) Type-specific regulation regulation of adenylyl cyclase. Selective pharmacological stimulation and inhibition of adenylyl cyclase isoforms. J.Biol.Chem. 276 47785 PMID: 11602596

Pierre et al (2009) Capturing adenylyl cyclases as potential drug targets. Nat.Rev.Drug Discov. 8 321 PMID: 19337273

If you know of a relevant reference for NKY 80, please let us know.

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Literature in this Area

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