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NKY 80 is an inhibitor of adenylyl cyclase (AC). Exhibits greater affinity for AC5 over AC3 and AC2 (IC50 values are 8.3 μM, 132 μM and 1.7 mM respectively).
NKY 80 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|ethanol||2.29||10 with gentle warming|
The following data is based on the product molecular weight 229.23. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||4.36 mL||21.81 mL||43.62 mL|
|5 mM||0.87 mL||4.36 mL||8.72 mL|
|10 mM||0.44 mL||2.18 mL||4.36 mL|
|50 mM||0.09 mL||0.44 mL||0.87 mL|
References are publications that support the biological activity of the product.
Onda et al (2001) Type-specific regulation regulation of adenylyl cyclase. Selective pharmacological stimulation and inhibition of adenylyl cyclase isoforms. J.Biol.Chem. 276 47785 PMID: 11602596
Pierre et al (2009) Capturing adenylyl cyclases as potential drug targets. Nat.Rev.Drug Discov. 8 321 PMID: 19337273
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Schizophrenia is a debilitating psychiatric disorder that affects 1% of the worldwide population. This poster describes the neurobiology of Schizophrenia, as well as highlighting the genetic and environmental factors that play a fundamental role in the etiology of the disease. The current and emerging drug targets are also discussed.