TDI 11861

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Description: Soluble adenylyl cyclase inhibitor
Chemical Name: (3R)-4-[2-[2-[[3-(2-Amino-6-chloro-4-pyrimidinyl)-1-(difluoromethyl)-1H-pyrazol-4-yl]methyl]phenoxy]ethyl]-3-morpholinemethanol
Purity: ≥98% (HPLC)

Biological Activity for TDI 11861

TDI 11861 is a potent and selective soluble adenylyl cyclase (sAC) inhibitor (IC50 values are 3.3 nM and 5.5 nM in biochemical and cellular assays, respectively; Kd = 1.4 nM). Inhibits cellular sAC-specific cAMP accumulation (IC50 = 7 nM) and blocks sperm capacitation in vitro. Cell permeable, not cytotoxic and suitable for both in vivo and in vitro use.

Licensing Information

Sold under license from Cornell University

Technical Data for TDI 11861

M. Wt 494.93
Formula C22H25ClF2N6O3
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2857049-72-8
PubChem ID 166101565
Smiles FC(F)N1N=C(C2=NC(N)=NC(Cl)=C2)C(CC3=C(C=CC=C3)OCCN4[C@@H](COCC4)CO)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for TDI 11861

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 49.49 100
ethanol 49.49 100

Preparing Stock Solutions for TDI 11861

The following data is based on the product molecular weight 494.93. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.02 mL 10.1 mL 20.2 mL
5 mM 0.4 mL 2.02 mL 4.04 mL
10 mM 0.2 mL 1.01 mL 2.02 mL
50 mM 0.04 mL 0.2 mL 0.4 mL

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References for TDI 11861

References are publications that support the biological activity of the product.

Miller et al (2022) Design, synthesis, and pharmacological evaluation of second-generation soluble adenylyl cyclase (sAC, ADCY10) inhibitors with slow dissociation rates. J.Med.Chem. 65 15208 PMID: 36346696

Balbach et al (2023) On-demand male contraception via acute inhibition of soluble adenylyl cyclase. Nat.Commun. 14 637 PMID: 36788210

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Citations for TDI 11861

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