TDI 11861

Pricing Availability   Qty

Save up to 40% on RUO Reagents with BIOSPRING24 (see details)

Description: Soluble adenylyl cyclase inhibitor
Chemical Name: (3R)-4-[2-[2-[[3-(2-Amino-6-chloro-4-pyrimidinyl)-1-(difluoromethyl)-1H-pyrazol-4-yl]methyl]phenoxy]ethyl]-3-morpholinemethanol
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews

Biological Activity for TDI 11861

TDI 11861 is a potent and selective soluble adenylyl cyclase (sAC) inhibitor (IC50 values are 3.3 nM and 5.5 nM in biochemical and cellular assays, respectively; Kd = 1.4 nM). Inhibits cellular sAC-specific cAMP accumulation (IC50 = 7 nM) and blocks sperm capacitation in vitro. Cell permeable, not cytotoxic and suitable for both in vivo and in vitro use.

Licensing Information

Sold under license from Cornell University

Technical Data for TDI 11861

M. Wt 494.93
Formula C22H25ClF2N6O3
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2857049-72-8
PubChem ID 166101565
InChI Key XVGSKZXXLKUEIO-MRXNPFEDSA-N
Smiles FC(F)N1N=C(C2=NC(N)=NC(Cl)=C2)C(CC3=C(C=CC=C3)OCCN4[C@@H](COCC4)CO)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for TDI 11861

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 49.49 100
ethanol 49.49 100

Preparing Stock Solutions for TDI 11861

The following data is based on the product molecular weight 494.93. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.02 mL 10.1 mL 20.2 mL
5 mM 0.4 mL 2.02 mL 4.04 mL
10 mM 0.2 mL 1.01 mL 2.02 mL
50 mM 0.04 mL 0.2 mL 0.4 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References for TDI 11861

References are publications that support the biological activity of the product.

Miller et al (2022) Design, synthesis, and pharmacological evaluation of second-generation soluble adenylyl cyclase (sAC, ADCY10) inhibitors with slow dissociation rates. J.Med.Chem. 65 15208 PMID: 36346696

Balbach et al (2023) On-demand male contraception via acute inhibition of soluble adenylyl cyclase. Nat.Commun. 14 637 PMID: 36788210


If you know of a relevant reference for TDI 11861, please let us know.

View Related Products by Product Action

View all Adenylyl Cyclase Inhibitors

Keywords: TDI 11861, TDI 11861 supplier, TDI11861, soluble, adenylyl, cyclase, inhibitor, inhibitors, inhibits, sAC, potent, selective, cell, permeable, Adenylyl, Cyclase, 8036, Tocris Bioscience

Citations for TDI 11861

Citations are publications that use Tocris products.

Currently there are no citations for TDI 11861. Do you know of a great paper that uses TDI 11861 from Tocris? Please let us know.

Reviews for TDI 11861

There are currently no reviews for this product. Be the first to review TDI 11861 and earn rewards!

Have you used TDI 11861?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review