PSB 603

Pricing Availability Delivery Time Qty
Cat.No. 3198 - PSB 603 | C24H25ClN6O4S | CAS No. 1092351-10-4
Description: Highly selective A2B antagonist
Chemical Name: 8-[4-[4-(4-Chlorophenzyl)piperazide-1-sulfonyl)phenyl]]-1-propylxanthine
Purity: ≥98% (HPLC)
Datasheet
Citations (5)
Reviews
Literature

Biological Activity

Adenosine A2B receptor antagonist that displays > 17000-fold selectivity over other adenosine receptors (Ki values are 0.553, > 10000, > 10000 and > 10000 nM for A2B, A1, A2A and A3 receptors respectively).

Compound Libraries

PSB 603 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 529.01
Formula C24H25ClN6O4S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1092351-10-4
PubChem ID 44185871
InChI Key OVHCTHHFOHMNFV-UHFFFAOYSA-N
Smiles O=C(NC2=C1NC(C3=CC=C(S(N4CCN(C5=CC=C(Cl)C=C5)CC4)(=O)=O)C=C3)=N2)N(CCC)C1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 26.45 50

Preparing Stock Solutions

The following data is based on the product molecular weight 529.01. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.89 mL 9.45 mL 18.9 mL
5 mM 0.38 mL 1.89 mL 3.78 mL
10 mM 0.19 mL 0.95 mL 1.89 mL
50 mM 0.04 mL 0.19 mL 0.38 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Borrmann et al (2009) 1-alkyl-8-(piperazine-1-sulfonyl)phenylxanthines: development and characterization of adenosine A2B receptor antagonists and a new radioligand with subnanomolar affinity and subtype specificity. J.Med.Chem. 52 3994 PMID: 19569717


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Keywords: PSB 603, supplier, selective, A2B, antagonists, Receptors, adenosines, PSB603, Adenosine, A2B, Receptors, Adenosine, A2B, Receptors, Tocris Bioscience

5 Citations for PSB 603

Citations are publications that use Tocris products. Selected citations for PSB 603 include:

Stoddart et al (2015) Application of BRET to monitor ligand binding to GPCRs. Nat Methods 12 661 PMID: 26030448

Rao et al (2015) Adenosine Signaling Mediates Osteogenic Differentiation of Human Embryonic Stem Cells on Mineralized Matrices. Front Bioeng Biotechnol 3 185 PMID: 26618155

Schneider et al (2015) Extracellular nucleotides as novel, underappreciated pro-metastatic factors that stimulate purinergic signaling in human lung cancer cells. Oncogene 14 201 PMID: 26597723

Long et al (2015) p73 engages A2B receptor signalling to prime cancer cells to chemotherapy-induced death. J Pharmacol Exp Ther 34 5152 PMID: 25659586

Ham et al (2010) Endogenous luminal surface adenosine signaling regulates duodenal bicarbonate secretion in rats. Proc Natl Acad Sci U S A 335 607 PMID: 20805305


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