PSB 603

Pricing Availability   Qty
Description: Highly selective A2B antagonist
Chemical Name: 8-[4-[4-(4-Chlorophenzyl)piperazide-1-sulfonyl)phenyl]]-1-propylxanthine
Purity: ≥98% (HPLC)
Citations (6)

Biological Activity for PSB 603

PSB 603 is an adenosine A2B receptor antagonist that displays > 17000-fold selectivity over other adenosine receptors (Ki values are 0.553, > 10000, > 10000 and > 10000 nM for A2B, A1, A2A and A3 receptors respectively).

Compound Libraries for PSB 603

PSB 603 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for PSB 603

M. Wt 529.01
Formula C24H25ClN6O4S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1092351-10-4
PubChem ID 44185871
Smiles O=C(NC2=C1NC(C3=CC=C(S(N4CCN(C5=CC=C(Cl)C=C5)CC4)(=O)=O)C=C3)=N2)N(CCC)C1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for PSB 603

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 26.45 50

Preparing Stock Solutions for PSB 603

The following data is based on the product molecular weight 529.01. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 3.78 mL 18.9 mL 37.81 mL
2.5 mM 0.76 mL 3.78 mL 7.56 mL
5 mM 0.38 mL 1.89 mL 3.78 mL
25 mM 0.08 mL 0.38 mL 0.76 mL

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Product Datasheets for PSB 603

Certificate of Analysis / Product Datasheet
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References for PSB 603

References are publications that support the biological activity of the product.

Borrmann et al (2009) 1-alkyl-8-(piperazine-1-sulfonyl)phenylxanthines: development and characterization of adenosine A2B receptor antagonists and a new radioligand with subnanomolar affinity and subtype specificity. J.Med.Chem. 52 3994 PMID: 19569717

If you know of a relevant reference for PSB 603, please let us know.

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Keywords: PSB 603, PSB 603 supplier, selective, A2B, antagonists, Receptors, adenosines, PSB603, Adenosine, 3198, Tocris Bioscience

6 Citations for PSB 603

Citations are publications that use Tocris products. Selected citations for PSB 603 include:

Stoddart et al (2015) Application of BRET to monitor ligand binding to GPCRs. Nat Methods 12 661 PMID: 26030448

Rao et al (2015) Adenosine Signaling Mediates Osteogenic Differentiation of Human Embryonic Stem Cells on Mineralized Matrices. Front Bioeng Biotechnol 3 185 PMID: 26618155

Kang et al (2016) Small molecule-driven direct conversion of human pluripotent stem cells into functional osteoblasts. Sci Adv 2 e1600691 PMID: 27602403

Ham et al (2010) Endogenous luminal surface adenosine signaling regulates duodenal bicarbonate secretion in rats. Proc Natl Acad Sci U S A 335 607 PMID: 20805305

Do you know of a great paper that uses PSB 603 from Tocris? Please let us know.

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