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Adenosine A2B receptor antagonist that displays > 17000-fold selectivity over other adenosine receptors (Ki values are 0.553, > 10000, > 10000 and > 10000 nM for A2B, A1, A2A and A3 receptors respectively).
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 529.01. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||3.78 mL||18.9 mL||37.81 mL|
|2.5 mM||0.76 mL||3.78 mL||7.56 mL|
|5 mM||0.38 mL||1.89 mL||3.78 mL|
|25 mM||0.08 mL||0.38 mL||0.76 mL|
References are publications that support the biological activity of the product.
Borrmann et al (2009) 1-alkyl-8-(piperazine-1-sulfonyl)phenylxanthines: development and characterization of adenosine A2B receptor antagonists and a new radioligand with subnanomolar affinity and subtype specificity. J.Med.Chem. 52 3994 PMID: 19569717
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Keywords: PSB 603, PSB 603 supplier, selective, A2B, antagonists, Receptors, adenosines, PSB603, Adenosine, 3198, Tocris Bioscience
6 Citations for PSB 603
Citations are publications that use Tocris products. Selected citations for PSB 603 include:
Stoddart et al (2015) Application of BRET to monitor ligand binding to GPCRs. Nat Methods 12 661 PMID: 26030448
Rao et al (2015) Adenosine Signaling Mediates Osteogenic Differentiation of Human Embryonic Stem Cells on Mineralized Matrices. Front Bioeng Biotechnol 3 185 PMID: 26618155
Schneider et al (2015) Extracellular nucleotides as novel, underappreciated pro-metastatic factors that stimulate purinergic signaling in human lung cancer cells. Oncogene 14 201 PMID: 26597723
Long et al (2015) p73 engages A2B receptor signalling to prime cancer cells to chemotherapy-induced death. J Pharmacol Exp Ther 34 5152 PMID: 25659586
Ham et al (2010) Endogenous luminal surface adenosine signaling regulates duodenal bicarbonate secretion in rats. Proc Natl Acad Sci U S A 335 607 PMID: 20805305
Kang et al (2016) Small molecule-driven direct conversion of human pluripotent stem cells into functional osteoblasts. Sci Adv 2 e1600691 PMID: 27602403
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Literature in this Area
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