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Submit ReviewPSB 0788
Description: Selective A2B antagonist
Chemical Name: 8-[4-[4-(4-Chlorobenzyl)piperazide-1-sulfonyl)phenyl]]-1-propylxanthine
Purity: ≥98% (HPLC)
Biological Activity for PSB 0788
PSB 0788 is a potent and selective adenosine A2B receptor antagonist (IC50 = 3.64 nM at human A2B receptors). Displays > 100-fold selectivity over hA1, hA2A and hA3 receptors.
Compound Libraries for PSB 0788
PSB 0788 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for PSB 0788
| M. Wt | 543.04 |
| Formula | C25H27ClN6O4S |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1027513-54-7 |
| PubChem ID | 44186581 |
| InChI Key | JQZJACVYMPKVDS-UHFFFAOYSA-N |
| Smiles | O=C(NC2=C1NC(C3=CC=C(S(N4CCN(CC5=CC=C(Cl)C=C5)CC4)(=O)=O)C=C3)=N2)N(CCC)C1=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for PSB 0788
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 54.3 | 100 |
Preparing Stock Solutions for PSB 0788
The following data is based on the product molecular weight 543.04. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.84 mL | 9.21 mL | 18.41 mL |
| 5 mM | 0.37 mL | 1.84 mL | 3.68 mL |
| 10 mM | 0.18 mL | 0.92 mL | 1.84 mL |
| 50 mM | 0.04 mL | 0.18 mL | 0.37 mL |
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Product Datasheets for PSB 0788
References for PSB 0788
References are publications that support the biological activity of the product.
Borrmann et al (2009) 1-alkyl-8-(piperazine-1-sulfonyl)phenylxanthines: development and characterization of adenosine A2B receptor antagonists and a new radioligand with subnanomolar affinity and subtype specificity. J.Med.Chem. 52 3994 PMID: 19569717
If you know of a relevant reference for PSB 0788, please let us know.
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Keywords: PSB 0788, PSB 0788 supplier, Selective, A2B, antagonists, Receptors, adenosines, PSB0788, Adenosine, 3199, Tocris Bioscience
2 Citations for PSB 0788
Citations are publications that use Tocris products. Selected citations for PSB 0788 include:
Al-Taei et al (2017) Prostaglandin E2-mediated adenosinergic effects on CD14+ cells: Self-amplifying immunosuppression in cancer. Oncoimmunology 6 e1268308 PMID: 28344879
Wakisaka et al (2017) An Adenosine Receptor for Olfaction in Fish. Curr Biol 27 1437 PMID: 28502661
Do you know of a great paper that uses PSB 0788 from Tocris? Please let us know.
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