PSB 0788
Biological Activity
Potent and selective adenosine A2B receptor antagonist (IC50 = 3.64 nM at human A2B receptors). Displays > 100-fold selectivity over hA1, hA2A and hA3 receptors.
Technical Data
| M. Wt | 543.04 |
| Formula | C25H27ClN6O4S |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1027513-54-7 |
| PubChem ID | 44186581 |
| InChI Key | JQZJACVYMPKVDS-UHFFFAOYSA-N |
| Smiles | O=C(NC2=C1NC(C3=CC=C(S(N4CCN(CC5=CC=C(Cl)C=C5)CC4)(=O)=O)C=C3)=N2)N(CCC)C1=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 54.3 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 543.04. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.84 mL | 9.21 mL | 18.41 mL |
| 5 mM | 0.37 mL | 1.84 mL | 3.68 mL |
| 10 mM | 0.18 mL | 0.92 mL | 1.84 mL |
| 50 mM | 0.04 mL | 0.18 mL | 0.37 mL |
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Product Datasheets
References
References are publications that support the biological activity of the product.
Borrmann et al (2009) 1-alkyl-8-(piperazine-1-sulfonyl)phenylxanthines: development and characterization of adenosine A2B receptor antagonists and a new radioligand with subnanomolar affinity and subtype specificity. J.Med.Chem. 52 3994 PMID: 19569717
If you know of a relevant reference for PSB 0788, please let us know.
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Keywords: PSB 0788, PSB 0788 supplier, Selective, A2B, antagonists, Receptors, adenosines, PSB0788, Adenosine, 3199, Tocris Bioscience
Citations for PSB 0788
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
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Cardiovascular Poster
Cardiovascular disease remains one of the major causes of morbidity and mortality in the Western world and therefore this therapeutic area continues to be of great interest to researchers. This poster highlights the key GPCRs regulating vascular reactivity.
