PSB 0788

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Cat.No. 3199 - PSB 0788 | C25H27ClN6O4S | CAS No. 1027513-54-7
Description: Selective A2B antagonist
Chemical Name: 8-[4-[4-(4-Chlorobenzyl)piperazide-1-sulfonyl)phenyl]]-1-propylxanthine
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Potent and selective adenosine A2B receptor antagonist (IC50 = 3.64 nM at human A2B receptors). Displays > 100-fold selectivity over hA1, hA2A and hA3 receptors.

Technical Data

M. Wt 543.04
Formula C25H27ClN6O4S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1027513-54-7
PubChem ID 44186581
InChI Key JQZJACVYMPKVDS-UHFFFAOYSA-N
Smiles O=C(NC2=C1NC(C3=CC=C(S(N4CCN(CC5=CC=C(Cl)C=C5)CC4)(=O)=O)C=C3)=N2)N(CCC)C1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 54.3 100

Preparing Stock Solutions

The following data is based on the product molecular weight 543.04. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.84 mL 9.21 mL 18.41 mL
5 mM 0.37 mL 1.84 mL 3.68 mL
10 mM 0.18 mL 0.92 mL 1.84 mL
50 mM 0.04 mL 0.18 mL 0.37 mL

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References

References are publications that support the biological activity of the product.

Borrmann et al (2009) 1-alkyl-8-(piperazine-1-sulfonyl)phenylxanthines: development and characterization of adenosine A2B receptor antagonists and a new radioligand with subnanomolar affinity and subtype specificity. J.Med.Chem. 52 3994 PMID: 19569717


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Citations for PSB 0788

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