PSB 0788
Biological Activity
Potent and selective adenosine A2B receptor antagonist (IC50 = 3.64 nM at human A2B receptors). Displays > 100-fold selectivity over hA1, hA2A and hA3 receptors.
Technical Data
| M. Wt | 543.04 |
| Formula | C25H27ClN6O4S |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1027513-54-7 |
| PubChem ID | 44186581 |
| InChI Key | JQZJACVYMPKVDS-UHFFFAOYSA-N |
| Smiles | O=C(NC2=C1NC(C3=CC=C(S(N4CCN(CC5=CC=C(Cl)C=C5)CC4)(=O)=O)C=C3)=N2)N(CCC)C1=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 54.3 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 543.04. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.84 mL | 9.21 mL | 18.41 mL |
| 5 mM | 0.37 mL | 1.84 mL | 3.68 mL |
| 10 mM | 0.18 mL | 0.92 mL | 1.84 mL |
| 50 mM | 0.04 mL | 0.18 mL | 0.37 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Borrmann et al (2009) 1-alkyl-8-(piperazine-1-sulfonyl)phenylxanthines: development and characterization of adenosine A2B receptor antagonists and a new radioligand with subnanomolar affinity and subtype specificity. J.Med.Chem. 52 3994 PMID: 19569717
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Keywords: Selective A2B antagonists Receptors adenosines PSB0788 Adenosine A2B Receptors
Citations for PSB 0788
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