MRS 1754

Pricing Availability   Qty
Cat.No. 2752 - MRS 1754 | C26H26N6O4 | CAS No. 264622-58-4
Description: Selective A2B antagonist
Chemical Name: N-(4-Cyanophenyl)-2-[4-(2,3,6,7-tetrahydro-2,6-dioxo-1,3-dipropyl-1H-purin-8-yl)phenoxy]-acetamide
Purity: ≥98% (HPLC)
Datasheet
Citations (16)
Reviews
Literature

Biological Activity

Selective adenosine A2B receptor antagonist (Ki values are 1.97, 16.8, 403, 503, 570 and 612 nM for hA2B, rA1, hA1, hA2A, hA3 and rA2A receptors respectively).

Licensing Information

Sold with the permission of the University of Virginia Patent Foundation

Technical Data

M. Wt 486.52
Formula C26H26N6O4
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 264622-58-4
PubChem ID 6603931
InChI Key AJBBEYXFRYFVNM-UHFFFAOYSA-N
Smiles CCCN1C2=C(NC(=N2)C2=CC=C(OCC(=O)NC3=CC=C(C=C3)C#N)C=C2)C(=O)N(CCC)C1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 2.43 5 with gentle warming
DMSO 4.87 10 with sonication

Preparing Stock Solutions

The following data is based on the product molecular weight 486.52. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 20.55 mL 102.77 mL 205.54 mL
0.5 mM 4.11 mL 20.55 mL 41.11 mL
1 mM 2.06 mL 10.28 mL 20.55 mL
5 mM 0.41 mL 2.06 mL 4.11 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Kim et al (2000) Anilide derivatives of an 8-phenylxanthine carboxylic congener are highly potent and selective antagonists at human A2B adenosine receptors. J.Med.Chem. 43 1165 PMID: 10737749

Ji et al (2001) [3H]MRS 1754, a selective antagonist radioligand for A2B adenosine receptors. Biochem.Pharmacol. 61 657 PMID: 11266650

Nemeth et al (2007) Adenosine receptor activation ameliorates type I diabetes. FASEB J. 21 2380


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Keywords: MRS 1754, MRS 1754 supplier, Selective, A2B, antagonists, Receptors, adenosines, MRS1754, Adenosine, 2752, Tocris Bioscience

16 Citations for MRS 1754

Citations are publications that use Tocris products. Selected citations for MRS 1754 include:

Pedroza et al (2011) Interleukin-6 contributes to inflammation and remodeling in a model of adenosine mediated lung injury. Mol Vis 6 e22667 PMID: 21799929

Kohno et al (2015) Anti-inflammatory effects of adenosine N1-oxide. Am J Physiol Lung Cell Mol Physiol 12 2 PMID: 25632271

Welihinda and Amento (2014) Positive allosteric modulation of the adenosine A2a receptor attenuates inflammation. J Inflamm (Lond) 11 37 PMID: 25473378

Ledderose et al (2016) Adenosine arrests breast cancer cell motility by A3 receptor stimulation. Purinergic Signalling PMID: 27577957

Gebremedhin et al (2010) Adenosine can mediate its actions through generation of reactive oxygen species. J Cereb Blood Flow Metab 30 1777 PMID: 20531463

Liu et al (2018) Adenosine binds predominantly to adenosine receptor A1 subtype in astrocytes and mediates an immunosuppressive effect. Brain Res 1700 47 PMID: 29935155

Garção et al (2013) Functional interaction between pre-synaptic α6β2-containing nicotinic and adenosine A2A receptors in the control of DA release in the rat striatum. Br J Pharmacol 169 1600 PMID: 23638679

Kan et al (2012) Imiquimod suppresses propagation of herpes simplex virus 1 by upregulation of cystatin A via the adenosine receptor A1 pathway. J Virol 86 10338 PMID: 22787201

He et al (2013) Adenosine regulates bone metabolism via A1, A2A, and A2B receptors in bone marrow cells from normal humans and patients with multiple myeloma. FASEB J 27 3446 PMID: 23682121

Asano (2017) Aminophylline suppresses stress-induced visceral hypersensitivity and defecation in irritable bowel syndrome. Scientific Reports 7 40214 PMID: 28054654

Lemos et al (2015) Adenosine A2B receptor activation stimulates glucose uptake in the mouse forebrain. Purinergic Signal 11 561 PMID: 26446689

Zhan et al (2011) Adenosine A2A and A2B receptors are both required for adenosine A1 receptor-mediated cardioprotection. Am J Physiol Heart Circ Physiol 301 H1183 PMID: 21743001

Hua et al (2011) IL-4 amplifies the pro-inflammatory effect of adenosine in human mast cells by changing expression levels of adenosine receptors. PLoS One 6 e24947 PMID: 21966389

Yu et al (2009) Effect of ventilation pressure on alveolar fluid clearance and β-agonist responses in mice. Am J Respir Crit Care Med 297 L785 PMID: 19684202

Wakisaka et al (2017) An Adenosine Receptor for Olfaction in Fish. Curr Biol 27 1437 PMID: 28502661

Wolk et al (2008) Influenza A virus inhibits alveolar fluid clearance in BALB/c mice. PLoS One 178 969 PMID: 18689466


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