BAY 60-6583

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Cat.No. 4472 - BAY 60-6583 | C19H17N5O2S | CAS No. 910487-58-0
Description: Potent partial A2B agonist; cardioprotective
Chemical Name: 2-[[6-Amino-3,5-dicyano-4-[4-(cyclopropylmethoxy)phenyl]-2-pyridinyl]thio]-acetamide
Purity: ≥98% (HPLC)
Citations (11)
Literature (4)

Biological Activity for BAY 60-6583

BAY 60-6583 is a partial agonist at adenosine A2B receptors (EC50 = 2.83 nM for murine A2B receptor). Displays selectivity for A2B over A1, A2A and A3 receptors. BAY 60-6583 antagonizes the effect of NECA (Cat. No. 1691) and adenosine (Cat. No. 3624) in cAMP accumulation assays. Decreases fMLP-induced superoxide production in neutrophils at low concentrations (1-10 nM). Cardioprotective; attenuates infarct size in a mouse model of myocardial ischemia. Exhibits ERK1/2-biased agonism.

Compound Libraries for BAY 60-6583

BAY 60-6583 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for BAY 60-6583

M. Wt 379.44
Formula C19H17N5O2S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 910487-58-0
PubChem ID 11717831
Smiles NC1=NC(SCC(N)=O)=C(C#N)C(C2=CC=C(OCC3CC3)C=C2)=C1C#N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for BAY 60-6583

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 37.94 100

Preparing Stock Solutions for BAY 60-6583

The following data is based on the product molecular weight 379.44. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.64 mL 13.18 mL 26.35 mL
5 mM 0.53 mL 2.64 mL 5.27 mL
10 mM 0.26 mL 1.32 mL 2.64 mL
50 mM 0.05 mL 0.26 mL 0.53 mL

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Product Datasheets for BAY 60-6583

Certificate of Analysis / Product Datasheet
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References for BAY 60-6583

References are publications that support the biological activity of the product.

Eckle et al (2007) Cardioprotection by ecto-5'-nucleotidase (CD73) and A2B adenosine receptors. Circulation 115 1581 PMID: 17353435

van der Hoeven et al (2011) A role for the low-affinity A2B adenosine receptor in regulating superoxide generation by murine neutrophils. J.Pharmacol.Exp.Ther. 338 1004 PMID: 21693629

Auchampach et al (2009) Characterization of the A2B adenosine receptor from mouse, rabbit, and dog. J.Pharmacol.Exp.Ther. 329 2 PMID: 19141710

Gao et al (2014) Probing biased/partial agonism at the G protein-coupled A2B adenosine receptor. Biochem. Pharmacol. 90 297 PMID: 24853985

Hinz et al (2014) BAY60-6583 acts as a partial agonist at adenosine A2B receptors. J.Pharmacol.Exp.Ther. 349 427 PMID: 24633424

If you know of a relevant reference for BAY 60-6583, please let us know.

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Keywords: BAY 60-6583, BAY 60-6583 supplier, BAY60-6583, adenosine, A2B, receptor, partial, agonists, agonism, potent, cAMP, cardioprotective, ischemia, superoxide, neutrophils, ERK1/2, biased, Adenosine, Receptors, 4472, Tocris Bioscience

11 Citations for BAY 60-6583

Citations are publications that use Tocris products. Selected citations for BAY 60-6583 include:

Jain et al (2018) Melanotan II causes hypothermia in mice by activation of mast cells and stimulation of histamine 1 receptors. Am J Physiol Endocrinol Metab 315 E357 PMID: 29812984

Asano (2017) Aminophylline suppresses stress-induced visceral hypersensitivity and defecation in irritable bowel syndrome. Scientific Reports 7 40214 PMID: 28054654

Song (2017) Erythrocytes retain hypoxic adenosine response for faster acclimatization upon re-ascent. Nat Commun 8 14108 PMID: 28169986

Perez-Aso et al (2015) Apremilast, a novel phosphodiesterase 4 (PDE4) inhibitor, regulates inflammation through multiple cAMP downstream effectors. Arthritis Res Ther 17 249 PMID: 26370839

Do you know of a great paper that uses BAY 60-6583 from Tocris? Please let us know.

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Literature in this Area

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