LUF 5834

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Cat.No. 4603 - LUF 5834 | CAS No. 333962-91-7
Description: Potent adenosine A2A and A2B receptor partial agonist
Chemical Name: 2-Amino-4-(4-hydroxyphenyl)-6-[(1H-imidazol-2-ylmethyl)thio]-3,5-pyridinecarbonitrile
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Potent A2A and A2B adenosine receptor partial agonist ( Ki = 2.6 nM and EC50 = 12 nM respectively). Also exhibits selectivity for A1 over A3 (Ki values are 2.6 and 538 nM respectively).

Compound Libraries

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Technical Data

M. Wt 348.38
Formula C17H12N6OS
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 333962-91-7
PubChem ID 1150683
InChI Key WLBUICQBNZXIDJ-UHFFFAOYSA-N
Smiles NC1=NC(SCC3=NC=CN3)=C(C#N)C(C2=CC=C(O)C=C2)=C1C#N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 34.84 100

Preparing Stock Solutions

The following data is based on the product molecular weight 348.38. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.87 mL 14.35 mL 28.7 mL
5 mM 0.57 mL 2.87 mL 5.74 mL
10 mM 0.29 mL 1.44 mL 2.87 mL
50 mM 0.06 mL 0.29 mL 0.57 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Beukers et al (2004) New, non-adenosine, high potency agonists for the human adenosine A2B receptor with an improved selectivity profile compared to the reference agonist N-ethylcarboxamidoadenosine J.Med.Chem 47 3707 PMID: 15239649

Lane et al (2012) A novel nonribose agonist, LUF5834, engages residues that are distinct from those of adenosine-like ligands to activate the adenosine A2a receptor Mol.Pharmacol. 81 475 PMID: 22188926


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Keywords: LUF 5834, supplier, LUF5834, potent, A2A, A2B, adenosine, receptors, agonists, Adenosine, A2A, Receptors, Tocris Bioscience

Citations for LUF 5834

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Literature in this Area

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Pathways for LUF 5834

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