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Biological Activity for LUF 5834
LUF 5834 is a potent A2A and A2B adenosine receptor partial agonist (Ki = 2.6 nM and EC50 = 12 nM respectively). Also exhibits selectivity for A1 over A3 (Ki values are 2.6 and 538 nM respectively).
Compound Libraries for LUF 5834
Technical Data for LUF 5834
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for LUF 5834
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for LUF 5834
The following data is based on the product molecular weight 348.38. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.87 mL||14.35 mL||28.7 mL|
|5 mM||0.57 mL||2.87 mL||5.74 mL|
|10 mM||0.29 mL||1.44 mL||2.87 mL|
|50 mM||0.06 mL||0.29 mL||0.57 mL|
References for LUF 5834
References are publications that support the biological activity of the product.
Beukers et al (2004) New, non-adenosine, high potency agonists for the human adenosine A2B receptor with an improved selectivity profile compared to the reference agonist N-ethylcarboxamidoadenosine J.Med.Chem 47 3707 PMID: 15239649
Lane et al (2012) A novel nonribose agonist, LUF5834, engages residues that are distinct from those of adenosine-like ligands to activate the adenosine A2a receptor Mol.Pharmacol. 81 475 PMID: 22188926
If you know of a relevant reference for LUF 5834, please let us know.
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Citations for LUF 5834
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Literature in this Area
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Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.