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Description: Potent inhibitor of Abl T315l mutant and wild-type Abl kinases
Chemical Name: 5-[3-(2-Methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-N,N-dimethyl-3-pyridinecarboxamide
Purity: ≥98% (HPLC)

Biological Activity for PPY A

PPY A is a potent inhibitor of T315l mutant and wild-type Abl kinases (IC50 values are 9 and 20 nM, respectively). Inhibits growth of cells transformed with either the Bcr-Abl T315l mutant or wild-type Bcr-Abl gene.

Compound Libraries for PPY A

PPY A is also offered as part of the Tocriscreen Kinase Inhibitor Library and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for PPY A

M. Wt 372.42
Formula C22H20N4O2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 875634-01-8
PubChem ID 16750094
Smiles O=C(N(C)C)C1=CN=CC(C2=CN=C(NC=C3C4=C(OC)C=CC=C4)C3=C2)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for PPY A

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 37.24 100

Preparing Stock Solutions for PPY A

The following data is based on the product molecular weight 372.42. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.69 mL 13.43 mL 26.85 mL
5 mM 0.54 mL 2.69 mL 5.37 mL
10 mM 0.27 mL 1.34 mL 2.69 mL
50 mM 0.05 mL 0.27 mL 0.54 mL

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Product Datasheets for PPY A

Certificate of Analysis / Product Datasheet
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References for PPY A

References are publications that support the biological activity of the product.

Zhou et al (2007) Crystal structure of the T315I mutant of AbI kinase. Chem.Biol.Drug.Des. 70 171 PMID: 17718712

Noronha et al (2008) Inhibitors of ABL and the ABL-T315I mutation. Curr.Top.Med.Chem. 8 905 PMID: 18673174

If you know of a relevant reference for PPY A, please let us know.

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Keywords: PPY A, PPY A supplier, PPYA, Bcr-Abl, BcrAbl, Bcr, Abl, fusion, tyrosine-kinase, inhibitors, inhibits, AblT315l, T315l, kinases, Kinase, 4730, Tocris Bioscience

Citations for PPY A

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