PPY A

Pricing Availability Delivery Time Qty
Cat.No. 4730 - PPY A | C22H20N4O2 | CAS No. 875634-01-8
Description: Potent inhibitor of Abl T315l mutant and wild-type Abl kinases
Chemical Name: 5-[3-(2-Methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-N,N-dimethyl-3-pyridinecarboxamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Potent inhibitor of T315l mutant and wild-type Abl kinases (IC50 values are 9 and 20 nM, respectively). Inhibits growth of cells transformed with either the Bcr-Abl T315l mutant or wild-type Bcr-Abl gene.

Compound Libraries

PPY A is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 372.42
Formula C22H20N4O2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 875634-01-8
PubChem ID 16750094
InChI Key GYQRHHQPEMOLKH-UHFFFAOYSA-N
Smiles O=C(N(C)C)C1=CN=CC(C2=CN=C(NC=C3C4=C(OC)C=CC=C4)C3=C2)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 37.24 100

Preparing Stock Solutions

The following data is based on the product molecular weight 372.42. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.69 mL 13.43 mL 26.85 mL
5 mM 0.54 mL 2.69 mL 5.37 mL
10 mM 0.27 mL 1.34 mL 2.69 mL
50 mM 0.05 mL 0.27 mL 0.54 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Zhou et al (2007) Crystal structure of the T315I mutant of AbI kinase. Chem.Biol.Drug.Des. 70 171 PMID: 17718712

Noronha et al (2008) Inhibitors of ABL and the ABL-T315I mutation. Curr.Top.Med.Chem. 8 905 PMID: 18673174


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Keywords: PPYA Bcr-Abl BcrAbl Bcr Abl fusion tyrosine-kinase inhibitors inhibits AblT315l T315l kinases Abl Kinase

Citations for PPY A

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Literature in this Area

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
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Kinases

Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

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  • Protein Kinases A, C, D and G
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  • MAPK Signaling
  • Receptor Serine/Threonine Kinases

Pathways for PPY A

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