Ras signaling inhibitor; inhibits Ack1 and germinal center kinase (GCK). Suppresses proliferation, and induces cell cycle arrest and apoptosis in leukemia cells harboring NRAS mutations. Prolongs survival in a leukemia cell xenotransplantation model in mice.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 547.53. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||3.65 mL||18.26 mL||36.53 mL|
|2.5 mM||0.73 mL||3.65 mL||7.31 mL|
|5 mM||0.37 mL||1.83 mL||3.65 mL|
|25 mM||0.07 mL||0.37 mL||0.73 mL|
References are publications that support the biological activity of the product.
Nonami et al (2015) Identification of novel therapeutic targets in acute leukemias with NRAS mutations using a pharmacologic approach. Blood 125 3133 PMID: 25833960
If you know of a relevant reference for GNF 7, please let us know.
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Keywords: GNF 7, GNF 7 supplier, GNF7, RAS, inhibitors, inhibits, Ack1, germinal, centre, kinases, GCK, leukemia, TNK2, G, Proteins, (Small), 5607, Tocris Bioscience
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