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Cat.No. 5607 - GNF 7 | C28H24F3N7O2 | CAS No. 839706-07-9
Description: Ras signaling inhibitor; inhibits Ack1 and GCK
Chemical Name: N-[3-[1,4-Dihydro-1-methyl-7-[(6-methyl-3-pyridinyl)amino]-2-oxopyrimido[4,5-d]pyrimidin-3(2H)-yl]-4-methylphenyl]-3-(trifluoromethyl)benzamide
Purity: ≥98% (HPLC)

Biological Activity

Ras signaling inhibitor; inhibits Ack1 and germinal center kinase (GCK). Suppresses proliferation, and induces cell cycle arrest and apoptosis in leukemia cells harboring NRAS mutations. Prolongs survival in a leukemia cell xenotransplantation model in mice.

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Technical Data

M. Wt 547.53
Formula C28H24F3N7O2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 839706-07-9
PubChem ID 11478363
Smiles CC1=NC=C(NC2=NC=C(CN(C3=C(C)C=CC(NC(C4=CC(C(F)(F)F)=CC=C4)=O)=C3)C(N5C)=O)C5=N2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 27.38 50

Preparing Stock Solutions

The following data is based on the product molecular weight 547.53. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 3.65 mL 18.26 mL 36.53 mL
2.5 mM 0.73 mL 3.65 mL 7.31 mL
5 mM 0.37 mL 1.83 mL 3.65 mL
25 mM 0.07 mL 0.37 mL 0.73 mL

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References are publications that support the biological activity of the product.

Nonami et al (2015) Identification of novel therapeutic targets in acute leukemias with NRAS mutations using a pharmacologic approach. Blood 125 3133 PMID: 25833960

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Keywords: GNF 7, GNF 7 supplier, GNF7, RAS, inhibitors, inhibits, Ack1, germinal, centre, kinases, GCK, leukemia, TNK2, G, Proteins, (Small), 5607, Tocris Bioscience

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Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis