GNF 2

Pricing Availability Delivery Time Qty
Cat.No. 4399 - GNF 2 | C18H13F3N4O2 | CAS No. 778270-11-4
Description: Selective allosteric inhibitor of Bcr-Abl tyrosine kinase activity
Chemical Name: 3-[6-[[4-(Trifluoromethoxy)phenyl]amino]-4-pyrimidinyl]benzamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Allosteric inhibitor of Bcr-Abl tyrosine kinase activity (IC50 = 267 nM); inhibits proliferation and induces apoptosis in Bcr-Abl-expressing cells. Selective for Bcr-Abl over a panel of serine, threonine and tyrosine kinases. Non-ATP-competitive.

Compound Libraries

GNF 2 is also offered as part of the Tocriscreen Plus and Tocriscreen Kinase Inhibitor Toolbox II. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 374.32
Formula C18H13F3N4O2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 778270-11-4
PubChem ID 5311510
InChI Key WEVYNIUIFUYDGI-UHFFFAOYSA-N
Smiles NC(C1=CC(C2=NC=NC(NC3=CC=C(OC(F)(F)F)C=C3)=C2)=CC=C1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 37.43 100
ethanol 18.72 50

Preparing Stock Solutions

The following data is based on the product molecular weight 374.32. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.67 mL 13.36 mL 26.72 mL
5 mM 0.53 mL 2.67 mL 5.34 mL
10 mM 0.27 mL 1.34 mL 2.67 mL
50 mM 0.05 mL 0.27 mL 0.53 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Zhang et al (2010) Targeting Bcr-Abl by combining allosteric with ATP-binding site inhibitors. Nature 463 501 PMID: 20072125

Adrián et al (2006) Allosteric inhibitors of Bcr-abl-dependent cell proliferation. Nat.Chem.Biol. 2 95 PMID: 16415863

Ohren & Sebolt-Leopold et al (2006) Inhibitors of Bcr-abl... breaking new ground again. Nat.Chem.Biol. 2 63 PMID: 16421581


If you know of a relevant reference for GNF 2, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Abl Kinase Inhibitors

Keywords: GNF 2, supplier, GNF2, bcrabl, bcr, abl, fusion, philadelphia, chromosome, antiproliferatives, apoptosis, inducers, chronic, myeloid, leukemia, leukaemia, allosteric, inhibits, inhibitors, selective, Abl, Kinase, Tocris Bioscience

Citations for GNF 2

Citations are publications that use Tocris products.

Currently there are no citations for GNF 2. Do you know of a great paper that uses GNF 2 from Tocris? If so please let us know.

Commented out for usability testing

Reviews

TODO: Add Reviews

Literature in this Area

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Kinases

Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

  • Receptor Tyrosine Kinases
  • Protein Kinases A, C, D and G
  • PI-3 Kinase, Akt and mTOR
  • MAPK Signaling
  • Receptor Serine/Threonine Kinases

Pathways for GNF 2

Protocols

TODO: Add Protocols