Discontinued Product

GNF 2 (Cat. No. 4399) has been withdrawn from sale for commercial reasons.
Description: Selective allosteric inhibitor of Bcr-Abl tyrosine kinase activity
Chemical Name: 3-[6-[[4-(Trifluoromethoxy)phenyl]amino]-4-pyrimidinyl]benzamide
Purity: ≥98% (HPLC)

Biological Activity for GNF 2

GNF 2 is an allosteric inhibitor of Bcr-Abl tyrosine kinase activity (IC50 = 267 nM); inhibits proliferation and induces apoptosis in Bcr-Abl-expressing cells. Selective for Bcr-Abl over a panel of serine, threonine and tyrosine kinases. Non-ATP-competitive.

Technical Data for GNF 2

M. Wt 374.32
Formula C18H13F3N4O2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 778270-11-4
PubChem ID 5311510
Smiles NC(C1=CC(C2=NC=NC(NC3=CC=C(OC(F)(F)F)C=C3)=C2)=CC=C1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for GNF 2

References are publications that support the biological activity of the product.

Zhang et al (2010) Targeting Bcr-Abl by combining allosteric with ATP-binding site inhibitors. Nature 463 501 PMID: 20072125

Adrián et al (2006) Allosteric inhibitors of Bcr-abl-dependent cell proliferation. Nat.Chem.Biol. 2 95 PMID: 16415863

Ohren & Sebolt-Leopold et al (2006) Inhibitors of Bcr-abl... breaking new ground again. Nat.Chem.Biol. 2 63 PMID: 16421581

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Citations for GNF 2

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