Cell Cycle Inhibitors

Cell cycle inhibitors slow or stop cell cycle progression through various mechanisms. Cell cycle arrest can be induced at different stages, decreasing the rate of cell division and the number of actively cycling cells.

Cell Cycle Inhibitor Products

Inhibitors
Cat.No.
Product Name / Activity
5981 Itraconazole
Inhibits cell cycle at G1 phase; also SMO antagonist
Other
Cat.No.
Product Name / Activity
4406 10058-F4
Arrests cell cycle at G0/G1
4138 ABT 751
Inhibitor of microtubule polymerization; blocks cell cycle at G2M
3968 AZD 5438
Blocks cell cycling at G2-M, S and G1 phases
1761 Baicalein
Induces G1 and G2 cell cycle arrest. Also lipoxygenase inhibitor
5144 CFM 4
CARP-1 mimetic; induces G2/M cell cycle arrest
4436 8-Chloroadenosine
Cytotoxic nucleoside analog; induces G2/M arrest
5800 CHMFL-FLT3-122
Arrests cell cycle in G0/G1; FLT3 inhibitor
5331 CPI 203
Arrests cell cycle at G1 phase; also BET bromodomain inhibitor
1417 Daidzein
Arrests cell cycle in G1 phase
4502 DIM
Activates Chk2; induces G2/M cell cycle arrest
3502 Epothilone B
Microtubule stabilization agent; promotes G2-M cell cycle arrest
1813 Indirubin-3'-oxime
Induces cell cycle arrest, antiproliferative
1230 Methotrexate
Cytotoxic agent
5231 MPC 6827 hydrochloride
Inhibitor of microtubule polymerization; antimitotic and antitumor
3715 Narciclasine
Antiproliferative agent; slows cell cycle progression
4761 Plumbagin
Induces G2/M cell cycle arrest; anticancer
4763 Pyridostatin pentahydrochloride
Stabilizes G-quadruplexes; induces DNA damage and cell cycle arrest
4817 SKPin C1
Inhibits Skp2-mediated p27 degradation; induces cell cycle arrest
5264 Temsirolimus
mTOR inhibitor; arrests cell cycle at G1/S
3909 Toceranib
Potent PDGFR and VEGFR inhibitor; induces cell cycle arrest
4282 WYE 687 dihydrochloride
Potent and selective mTOR inhibitor; induces G1 cell cycle arrest
5493 XL 413 hydrochloride
Potent and selective Cdc7 inhibitor
4307 YC 1
Soluble guanylyl cyclase (sGC) activator; induces G1 cell cycle arrest

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