AZD 5438

Pricing Availability Delivery Time Qty
Cat.No. 3968 - AZD 5438 | C18H21N5O2S | CAS No. 602306-29-6
Description: Potent cyclin-dependent kinase (cdk) 1, 2 and 9 inhibitor
Chemical Name: 4-[2-Methyl-1-(1-methylethyl)-1H-imidazol-5-yl]-N-[4-(methylsulfonyl)phenyl]-2-pyrimidinamine
Purity: ≥99% (HPLC)
Datasheet
Citations (2)
Literature

Biological Activity

Potent inhibitor of cyclin-dependent kinase (cdk) 1, 2 and 9 (IC50 values are 16, 6 and 20 nM respectively). Exhibits antiproliferative activity in human tumor cell lines. Blocks cell cycling at G2-M, S and G1 phases; reduces the proportion of actively cycling cells in vivo.

Licensing Information

Sold with the permission of AstraZeneca UK Ltd.

Compound Libraries

AZD 5438 is also offered as part of the Tocriscreen Plus and Tocriscreen Kinase Inhibitor Toolbox I. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 371.46
Formula C18H21N5O2S
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 602306-29-6
PubChem ID 16747683
InChI Key WJRRGYBTGDJBFX-UHFFFAOYSA-N
Smiles CS(C(C=C3)=CC=C3NC1=NC(C2=CN=C(C)N2C(C)C)=CC=N1)(=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 37.15 100

Preparing Stock Solutions

The following data is based on the product molecular weight 371.46. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.69 mL 13.46 mL 26.92 mL
5 mM 0.54 mL 2.69 mL 5.38 mL
10 mM 0.27 mL 1.35 mL 2.69 mL
50 mM 0.05 mL 0.27 mL 0.54 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Byth et al (2009) AZD5438, a potent oral inhibitor of cyclin-dependent kinases 1, 2 and 9, leads to pharmacodynamic changes and potent antitumor effects in human tumor xenografts. Mol.Cancer Ther. 8 1856 PMID: 19509270


If you know of a relevant reference for AZD 5438, please let us know.

View Related Products by Product Action

View all Cyclin-Dependent Protein Kinase Inhibitors

Keywords: AZD5438 Cdk inhibitor cyclin-dependent kinase inhibitors inhibits cdk1 cdk2 cdk9 Cyclin-dependent Kinase

2 Citations for AZD 5438

Citations are publications that use Tocris products. Selected citations for AZD 5438 include:

Natrajan et al (2012) Functional characterization of the 19q12 amplicon in grade III breast cancers. Breast Cancer Res 14 R53 PMID: 22433433

Goonesekere et al (2014) A meta analysis of pancreatic microarray datasets yields new targets as cancer genes and biomarkers. PLoS One 9 e93046 PMID: 24740004


Do you know of a great paper that uses AZD 5438 from Tocris? If so please let us know.

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Literature in this Area

Cancer

Cancer Research Product Guide

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  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
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Kinases

Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

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  • Protein Kinases A, C, D and G
  • PI-3 Kinase, Akt and mTOR
  • MAPK Signaling
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Neurodegeneration

Neurodegeneration Product Guide

A collection of over 275 products for neurodegeneration research, the guide includes research tools for the study of:

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Cell Cycle & DNA Damage Repair

Cell Cycle & DNA Damage Repair Poster

In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.

Pathways for AZD 5438

Protocols

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