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Biological Activity for AZD 5438
AZD 5438 is a potent inhibitor of cyclin dependent kinases (cdks; reported IC50 values are 6 - 45, 14, 16 and 20 nM for cdk2, cdk5, cdk1 and cdk9 respectively). Also inhibits cdk4 and cdk7 in the sub micromolar range. Exhibits antiproliferative activity in human tumor cell lines. Blocks cell cycling at G2-M, S and G1 phases; reduces the proportion of actively cycling cells in vivo.
Sold with the permission of AstraZeneca UK Ltd.
Compound Libraries for AZD 5438
Technical Data for AZD 5438
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for AZD 5438
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for AZD 5438
The following data is based on the product molecular weight 371.46. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.69 mL||13.46 mL||26.92 mL|
|5 mM||0.54 mL||2.69 mL||5.38 mL|
|10 mM||0.27 mL||1.35 mL||2.69 mL|
|50 mM||0.05 mL||0.27 mL||0.54 mL|
References for AZD 5438
References are publications that support the biological activity of the product.
Byth et al (2009) AZD5438, a potent oral inhibitor of cyclin-dependent kinases 1, 2 and 9, leads to pharmacodynamic changes and potent antitumor effects in human tumor xenografts. Mol.Cancer Ther. 8 1856 PMID: 19509270
Jorda et al (2018) How selective are pharmacological inhibitors of cell-cycle-regulating cyclin-dependent kinases? J.Med.Chem. 61 9105 PMID: 30234987
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Keywords: AZD 5438, AZD 5438 supplier, AZD5438, Cdk, inhibitor, cyclin-dependent, kinase, inhibitors, inhibits, cdk1, cdk2, cdk9, Cell, Cycle, Inhibitors, Cyclin-dependent, Kinase, Non-selective, CDKs, 3968, Tocris Bioscience
4 Citations for AZD 5438
Citations are publications that use Tocris products. Selected citations for AZD 5438 include:
Natrajan et al (2012) Functional characterization of the 19q12 amplicon in grade III breast cancers. Breast Cancer Res 14 R53 PMID: 22433433
Helen et al (2023) AZD5438 a GSK-3a/b and CDK inhibitor is antiapoptotic modulates mitochondrial activity and protects human neurons from mitochondrial toxins. Sci Rep 13 8334 PMID: 37221196
Cheng et al (2022) Translational and post-translational control of human naïve versus primed pluripotency. iScience 25 103645 PMID: 35005567
Goonesekere et al (2014) A meta analysis of pancreatic microarray datasets yields new targets as cancer genes and biomarkers. PLoS One 9 e93046 PMID: 24740004
Do you know of a great paper that uses AZD 5438 from Tocris? Please let us know.
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