XL 413 hydrochloride
Potent and selective Cdc7 inhibitor (IC50 = 3.4 nM). Exhibits >12-fold selectivity for Cdc7 over PIM-1 kinase and >30-fold selectivity over pMCM and CK2. Inhibits proliferation of Colo 205 cells in vitro and attenuates tumor growth of Colo 205 xenografts in mice.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 326.18. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.2 mM||15.33 mL||76.64 mL||153.29 mL|
|1 mM||3.07 mL||15.33 mL||30.66 mL|
|2 mM||1.53 mL||7.66 mL||15.33 mL|
|10 mM||0.31 mL||1.53 mL||3.07 mL|
References are publications that support the biological activity of the product.
Sasi et al (2014) The potent Cdc7-Dbf4 (DDK) kinase inhibitor XL413 has limited activity in many cancer cell lines and discovery of potential new DDK inhibitor scaffolds. PLoS ONE 9 e113300 PMID: 25412417
Koltun et al (2012) Discovery of XL413, a potent and selective CDC7 inhibitor. Bioorg.Med.Chem.Lett. 22 3727 PMID: 22560567
If you know of a relevant reference for XL 413 hydrochloride, please let us know.
View Related Products by Product Action
Keywords: XL 413 hydrochloride, XL 413 hydrochloride supplier, XL413, hydrochloride, BMS863233, potent, selective, inhibits, inhibitors, cdc7, cell, division, cycle, kinases, BMS, 863233, Other, Kinases, Cell, Cycle, Inhibitors, 5493, Tocris Bioscience
Citations for XL 413 hydrochloride
Citations are publications that use Tocris products.
Currently there are no citations for XL 413 hydrochloride. Do you know of a great paper that uses XL 413 hydrochloride from Tocris? Please let us know.
Reviews for XL 413 hydrochloride
There are currently no reviews for this product. Be the first to review XL 413 hydrochloride and earn rewards!
Have you used XL 413 hydrochloride?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.