XL 413 hydrochloride

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Description: Potent and selective Cdc7 inhibitor
Alternative Names: BMS 863233
Chemical Name: 8-Chloro-2-(2S)-2-pyrrolidinylbenzofuro[3,2-d]pyrimidin-4(3H)-one hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature (2)

Biological Activity for XL 413 hydrochloride

XL 413 hydrochloride is a potent and selective Cdc7 inhibitor (IC50 = 3.4 nM). Exhibits >12-fold selectivity for Cdc7 over PIM-1 kinase and >30-fold selectivity over pMCM and CK2. Inhibits proliferation of Colo 205 cells in vitro and attenuates tumor growth of Colo 205 xenografts in mice. XL 413 also improves homology-directed repair (HDR) editing in hematopoietic stem cells (HSC).

Technical Data for XL 413 hydrochloride

M. Wt 326.18
Formula C14H12ClN3O2.HCl
Storage Store at -20°C
Purity ≥99% (HPLC)
CAS Number 1169562-71-3
PubChem ID 67185304
InChI Key UNDKJUKLBNARIZ-FVGYRXGTSA-N
Smiles ClC1=CC=C2C(C(N=[C@@]([C@H]4NCCC4)NC3=O)=C3O2)=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for XL 413 hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 6.52 20

Preparing Stock Solutions for XL 413 hydrochloride

The following data is based on the product molecular weight 326.18. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 15.33 mL 76.64 mL 153.29 mL
1 mM 3.07 mL 15.33 mL 30.66 mL
2 mM 1.53 mL 7.66 mL 15.33 mL
10 mM 0.31 mL 1.53 mL 3.07 mL

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Product Datasheets for XL 413 hydrochloride

References for XL 413 hydrochloride

References are publications that support the biological activity of the product.

Sasi et al (2014) The potent Cdc7-Dbf4 (DDK) kinase inhibitor XL413 has limited activity in many cancer cell lines and discovery of potential new DDK inhibitor scaffolds. PLoS ONE 9 e113300 PMID: 25412417

Koltun et al (2012) Discovery of XL413, a potent and selective CDC7 inhibitor. Bioorg.Med.Chem.Lett. 22 3727 PMID: 22560567

Azhagiri et al (2021) Homology-directed gene-editing approaches for hematopoietic stem and progenitor cell gene therapy. Stem Cell Res.Ther. 12 500 PMID: 34503562


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Citations for XL 413 hydrochloride

Citations are publications that use Tocris products.

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Literature in this Area

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Cancer Research Product Guide

Cancer Research Product Guide

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