Home / Pharmacology / Enzymes / Kinases / Other Kinases / Other Kinase Inhibitors / XL 413 hydrochloride

XL 413 hydrochloride

Cat. No. 5493 Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Potent and selective Cdc7 inhibitor
Alternative Names: BMS 863233
Chemical Name: 8-Chloro-2-(2S)-2-pyrrolidinylbenzofuro[3,2-d]pyrimidin-4(3H)-one hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature (2)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for XL 413 hydrochloride

XL 413 hydrochloride is a potent and selective Cdc7 inhibitor (IC50 = 3.4 nM). Exhibits >12-fold selectivity for Cdc7 over PIM-1 kinase and >30-fold selectivity over pMCM and CK2. Inhibits proliferation of Colo 205 cells in vitro and attenuates tumor growth of Colo 205 xenografts in mice. XL 413 also improves homology-directed repair (HDR) editing in hematopoietic stem cells (HSC).

Technical Data for XL 413 hydrochloride

M. Wt 326.18
Formula C14H12ClN3O2.HCl
Storage Store at -20°C
Purity ≥99% (HPLC)
CAS Number 1169562-71-3
PubChem ID 67185304
InChI Key UNDKJUKLBNARIZ-FVGYRXGTSA-N
Smiles ClC1=CC=C2C(C(N=[C@@]([C@H]4NCCC4)NC3=O)=C3O2)=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for XL 413 hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 6.52 20

Preparing Stock Solutions for XL 413 hydrochloride

The following data is based on the product molecular weight 326.18. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 15.33 mL 76.64 mL 153.29 mL
1 mM 3.07 mL 15.33 mL 30.66 mL
2 mM 1.53 mL 7.66 mL 15.33 mL
10 mM 0.31 mL 1.53 mL 3.07 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets for XL 413 hydrochloride

Certificate of Analysis / Product Datasheet
Safety Datasheet

References for XL 413 hydrochloride

References are publications that support the biological activity of the product.

Sasi et al (2014) The potent Cdc7-Dbf4 (DDK) kinase inhibitor XL413 has limited activity in many cancer cell lines and discovery of potential new DDK inhibitor scaffolds. PLoS ONE 9 e113300 PMID: 25412417

Koltun et al (2012) Discovery of XL413, a potent and selective CDC7 inhibitor. Bioorg.Med.Chem.Lett. 22 3727 PMID: 22560567

Azhagiri et al (2021) Homology-directed gene-editing approaches for hematopoietic stem and progenitor cell gene therapy. Stem Cell Res.Ther. 12 500 PMID: 34503562

If you know of a relevant reference for XL 413 hydrochloride, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Other Kinase Inhibitors

Keywords: XL 413 hydrochloride, XL 413 hydrochloride supplier, XL413, hydrochloride, BMS863233, potent, selective, inhibits, inhibitors, cdc7, cell, division, cycle, kinases, hematopoietic, haematopoietic, stem, cells, HSC, HSCs, BMS, 863233, Other, Kinases, Cell, Cycle, Inhibitors, Hematopoietic, Stem, Cells, CRISPR, Reagents, 5493, Tocris Bioscience

Citations for XL 413 hydrochloride

Citations are publications that use Tocris products.

Currently there are no citations for XL 413 hydrochloride. Do you know of a great paper that uses XL 413 hydrochloride from Tocris? Please let us know.

Reviews for XL 413 hydrochloride

There are currently no reviews for this product. Be the first to review XL 413 hydrochloride and earn rewards!

Have you used XL 413 hydrochloride?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Cancer Research Product Guide

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Kinases Product Listing

Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

  • Receptor Tyrosine Kinases
  • Protein Kinases A, C, D and G
  • PI-3 Kinase, Akt and mTOR
  • MAPK Signaling
  • Receptor Serine/Threonine Kinases