XL 413 hydrochloride

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Cat.No. 5493 - XL 413 hydrochloride | C14H12ClN3O2.HCl | CAS No. 1169562-71-3
Description: Potent and selective Cdc7 inhibitor
Alternative Names: BMS 863233
Chemical Name: 8-Chloro-2-(2S)-2-pyrrolidinylbenzofuro[3,2-d]pyrimidin-4(3H)-one hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Potent and selective Cdc7 inhibitor (IC50 = 3.4 nM). Exhibits >12-fold selectivity for Cdc7 over PIM-1 kinase and >30-fold selectivity over pMCM and CK2. Inhibits proliferation of Colo 205 cells in vitro and attenuates tumor growth of Colo 205 xenografts in mice.

Technical Data

M. Wt 326.18
Formula C14H12ClN3O2.HCl
Storage Store at -20°C
Purity ≥99% (HPLC)
CAS Number 1169562-71-3
PubChem ID 67185304
InChI Key UNDKJUKLBNARIZ-FVGYRXGTSA-N
Smiles ClC1=CC=C2C(C(N=[C@@]([C@H]4NCCC4)NC3=O)=C3O2)=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 6.52 20

Preparing Stock Solutions

The following data is based on the product molecular weight 326.18. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 15.33 mL 76.64 mL 153.29 mL
1 mM 3.07 mL 15.33 mL 30.66 mL
2 mM 1.53 mL 7.66 mL 15.33 mL
10 mM 0.31 mL 1.53 mL 3.07 mL

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References

References are publications that support the biological activity of the product.

Sasi et al (2014) The potent Cdc7-Dbf4 (DDK) kinase inhibitor XL413 has limited activity in many cancer cell lines and discovery of potential new DDK inhibitor scaffolds. PLoS ONE 9 e113300 PMID: 25412417

Koltun et al (2012) Discovery of XL413, a potent and selective CDC7 inhibitor. Bioorg.Med.Chem.Lett. 22 3727 PMID: 22560567


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Citations for XL 413 hydrochloride

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