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XL 413 hydrochloride is a potent and selective Cdc7 inhibitor (IC50 = 3.4 nM). Exhibits >12-fold selectivity for Cdc7 over PIM-1 kinase and >30-fold selectivity over pMCM and CK2. Inhibits proliferation of Colo 205 cells in vitro and attenuates tumor growth of Colo 205 xenografts in mice. XL 413 also improves homology-directed repair (HDR) editing in hematopoietic stem cells (HSC).
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
The following data is based on the product molecular weight 326.18. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.2 mM||15.33 mL||76.64 mL||153.29 mL|
|1 mM||3.07 mL||15.33 mL||30.66 mL|
|2 mM||1.53 mL||7.66 mL||15.33 mL|
|10 mM||0.31 mL||1.53 mL||3.07 mL|
References are publications that support the biological activity of the product.
Sasi et al (2014) The potent Cdc7-Dbf4 (DDK) kinase inhibitor XL413 has limited activity in many cancer cell lines and discovery of potential new DDK inhibitor scaffolds. PLoS ONE 9 e113300 PMID: 25412417
Koltun et al (2012) Discovery of XL413, a potent and selective CDC7 inhibitor. Bioorg.Med.Chem.Lett. 22 3727 PMID: 22560567
Azhagiri et al (2021) Homology-directed gene-editing approaches for hematopoietic stem and progenitor cell gene therapy. Stem Cell Res.Ther. 12 500 PMID: 34503562
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