Pricing Availability Delivery Time Qty
Cat.No. 4406 - 10058-F4 | C12H11NOS2 | CAS No. 403811-55-2
Description: Inhibits c-Myc-Max dimerization
Chemical Name: 5-[(4-Ethylphenyl)methylene]-2-thioxo-4-thiazolidinone
Purity: ≥99% (HPLC)

Biological Activity

Cell permeable c-Myc-Max dimerization inhibitor. Inhibits proliferation, induces apoptosis and arrests cells in G0/G1 in rat1a-c-Myc cells. Also reduces tumor growth in vivo.

Compound Libraries

10058-F4 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 249.35
Formula C12H11NOS2
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 403811-55-2
PubChem ID 1271002
Smiles O=C(NC(S2)=S)/C2=C\C1=CC=C(CC)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 24.93 100
ethanol 4.99 20

Preparing Stock Solutions

The following data is based on the product molecular weight 249.35. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.01 mL 20.05 mL 40.1 mL
5 mM 0.8 mL 4.01 mL 8.02 mL
10 mM 0.4 mL 2.01 mL 4.01 mL
50 mM 0.08 mL 0.4 mL 0.8 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

Yin et al (2003) Low molecular weight inhibitors of Myc-Max interaction and function. Oncogene 22 6151 PMID: 13679853

Huang et al (2006) A small-molecule c-Myc inhibitor, 10058-F4, induces cell-cycle arrest, apoptosis, and myeloid differentiation of human acute myeloid leukemia. Exp.Hematol. 34 1480 PMID: 17046567

Guo et al (2009) Efficacy, pharmacokinetics, tisssue distribution, and metabolism of the Myc-Max disruptor, 10058-F4 [Z,E]-5-[4-ethylbenzylidine]-2-thioxothiazolidin-4-one, in mice. Cancer Chemother.Pharmacol. 63 615 PMID: 18509642

If you know of a relevant reference for 10058-F4, please let us know.

View Related Products by Product Action

View all MYC Inhibitors

Keywords: 10058-F4, supplier, cell, permeable, c-Myc, cMyc, inhibits, inhibitors, arrests, cell, cycle, G1/G0, 10058-F4, antitumorigenic, antitumourigenic, proliferation, apoptosis, reduces, tumor, growth, tumour, c-Myc-Max, max, Cell, Cycle, Inhibitors, Myc, MYC, Myc, Tocris Bioscience

Citations for 10058-F4

Citations are publications that use Tocris products.

Currently there are no citations for 10058-F4. Do you know of a great paper that uses 10058-F4 from Tocris? If so please let us know.

Commented out for usability testing


TODO: Add Reviews

Literature in this Area


Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Stem Cells

Stem Cells Scientific Review

Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.

Pathways for 10058-F4


MAPK Signaling Pathway

The mitogen-activated protein kinase pathway evokes an intracellular signaling cascade in response to extracellular stimuli such as heat and stress. It can influence cell division, metabolism and survival.


TODO: Add Protocols