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Description: Inhibits c-Myc-Max dimerization
Chemical Name: 5-[(4-Ethylphenyl)methylene]-2-thioxo-4-thiazolidinone
Purity: ≥99% (HPLC)
Reviews (1)
Literature (3)
Pathways (1)

Biological Activity for 10058-F4

10058-F4 is a cell permeable c-Myc-Max dimerization inhibitor. Inhibits proliferation, induces apoptosis and arrests cells in G0/G1 in rat1a-c-Myc cells. Also reduces tumor growth in vivo. In lymphoma cells, 10058-F4 decreases glucose uptake and expression of glycolysis-associated genes and reduces cell viability.

Compound Libraries for 10058-F4

10058-F4 is also offered as part of the Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for 10058-F4

M. Wt 249.35
Formula C12H11NOS2
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 403811-55-2
PubChem ID 1271002
Smiles O=C(NC(S2)=S)/C2=C\C1=CC=C(CC)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for 10058-F4

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 24.93 100
ethanol 4.99 20

Preparing Stock Solutions for 10058-F4

The following data is based on the product molecular weight 249.35. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.01 mL 20.05 mL 40.1 mL
5 mM 0.8 mL 4.01 mL 8.02 mL
10 mM 0.4 mL 2.01 mL 4.01 mL
50 mM 0.08 mL 0.4 mL 0.8 mL

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References for 10058-F4

References are publications that support the biological activity of the product.

Yin et al (2003) Low molecular weight inhibitors of Myc-Max interaction and function. Oncogene 22 6151 PMID: 13679853

Huang et al (2006) A small-molecule c-Myc inhibitor, 10058-F4, induces cell-cycle arrest, apoptosis, and myeloid differentiation of human acute myeloid leukemia. Exp.Hematol. 34 1480 PMID: 17046567

Guo et al (2009) Efficacy, pharmacokinetics, tisssue distribution, and metabolism of the Myc-Max disruptor, 10058-F4 [Z,E]-5-[4-ethylbenzylidine]-2-thioxothiazolidin-4-one, in mice. Cancer Chemother.Pharmacol. 63 615 PMID: 18509642

Broecker-Preuss et al (2017) Regulation of glucose uptake in lymphoma cell lines by c-MYC- and PI3K-dependent signaling pathways and impact of glycolytic pathways on cell viability J.Transl.Med. 15 158 PMID: 28724379

If you know of a relevant reference for 10058-F4, please let us know.

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Citations for 10058-F4

Citations are publications that use Tocris products.

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Reviews for 10058-F4

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works perfectly.
By Anonymous on 07/28/2019
Assay Type: In Vitro
Species: Human

Used the compound for studying the anti-cancer properties. The compound 10058-F4, strongly induced caspase‐3‐dependent apoptosis in pre‐B ALL cells.

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Cancer Metabolism Research Product Guide

Cancer Metabolism Research Product Guide

This product guide reviews some of the main areas in cancer metabolism research and lists around 150 products that can be used to investigate metabolic pathways in cancer including:

Stem Cells Scientific Review

Stem Cells Scientific Review

Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.

Stem Cells Poster

Stem Cells Poster

Written by Rebecca Quelch and Stefan Przyborski from Durham University (UK), this poster describes the isolation of pluripotent stem cells, their maintenance in culture, differentiation, and the generation and potential uses of organoids.

Pathways for 10058-F4

MAPK Signaling Pathway

MAPK Signaling Pathway

The mitogen-activated protein kinase pathway evokes an intracellular signaling cascade in response to extracellular stimuli such as heat and stress. It can influence cell division, metabolism and survival.