10058-F4

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Cat.No. 4406 - 10058-F4 | C12H11NOS2 | CAS No. 403811-55-2
Description: Inhibits c-Myc-Max dimerization
Chemical Name: 5-[(4-Ethylphenyl)methylene]-2-thioxo-4-thiazolidinone
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature
Pathways

Biological Activity

Cell permeable c-Myc-Max dimerization inhibitor. Inhibits proliferation, induces apoptosis and arrests cells in G0/G1 in rat1a-c-Myc cells. Also reduces tumor growth in vivo.

Compound Libraries

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Technical Data

M. Wt 249.35
Formula C12H11NOS2
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 403811-55-2
PubChem ID 1271002
InChI Key SVXDHPADAXBMFB-JXMROGBWSA-N
Smiles O=C(NC(S2)=S)/C2=C\C1=CC=C(CC)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 24.93 100
ethanol 4.99 20

Preparing Stock Solutions

The following data is based on the product molecular weight 249.35. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.01 mL 20.05 mL 40.1 mL
5 mM 0.8 mL 4.01 mL 8.02 mL
10 mM 0.4 mL 2.01 mL 4.01 mL
50 mM 0.08 mL 0.4 mL 0.8 mL

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References

References are publications that support the biological activity of the product.

Yin et al (2003) Low molecular weight inhibitors of Myc-Max interaction and function. Oncogene 22 6151 PMID: 13679853

Huang et al (2006) A small-molecule c-Myc inhibitor, 10058-F4, induces cell-cycle arrest, apoptosis, and myeloid differentiation of human acute myeloid leukemia. Exp.Hematol. 34 1480 PMID: 17046567

Guo et al (2009) Efficacy, pharmacokinetics, tisssue distribution, and metabolism of the Myc-Max disruptor, 10058-F4 [Z,E]-5-[4-ethylbenzylidine]-2-thioxothiazolidin-4-one, in mice. Cancer Chemother.Pharmacol. 63 615 PMID: 18509642


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Citations for 10058-F4

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Stem Cells

Stem Cells Scientific Review

Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.

Stem Cells

Stem Cells Poster

Written by Rebecca Quelch and Stefan Przyborski from Durham University (UK), this poster describes the isolation of pluripotent stem cells, their maintenance in culture, differentiation, and the generation and potential uses of organoids.

Pathways for 10058-F4

MAPK

MAPK Signaling Pathway

The mitogen-activated protein kinase pathway evokes an intracellular signaling cascade in response to extracellular stimuli such as heat and stress. It can influence cell division, metabolism and survival.