SMO antagonist (IC50 = 690 nM); acts at different binding site to cyclopamine (Cat. No. 1623). Also cytochrome p450 inhibitor (IC50 = 16-26 nM). Inhibits cell cycle at G1 phase in vitro and blocks angiogenesis in vivo (IC50 = 160 nM). Antifungal.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|DMSO||14.11||20 with gentle warming|
Preparing Stock Solutions
The following data is based on the product molecular weight 705.63. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.2 mM||7.09 mL||35.43 mL||70.86 mL|
|1 mM||1.42 mL||7.09 mL||14.17 mL|
|2 mM||0.71 mL||3.54 mL||7.09 mL|
|10 mM||0.14 mL||0.71 mL||1.42 mL|
References are publications that support the biological activity of the product.
Chong et al (2007) Inhibition of angiogenesis by the antifungal drug itraconazole. ACS Chem.Biol. 2 263 PMID: 17432820
Kim et al (2013) Itraconazole and arsenic trioxide inhibit Hedgehog pathway activation and tumor growth associated with acquired resistance to smoothened antagonists. Cancer Cell 23 23 PMID: 23291299
Kim et al (2010) Itraconazole, a commonly used antifungal that inhibits Hedgehog pathway activity and cancer growth. Cancer Cell 17 388 PMID: 20385363
Pace et al (2016) Repurposing the clinically efficacious antifungal agent itraconazole as an anticancer chemotherapeutic. J.Med.Chem. 59 3635 PMID: 27014922
If you know of a relevant reference for Itraconazole, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: Itraconazole, Itraconazole supplier, SMO, antagonists, smoothened, receptors, cytochrome, p450, inhiibitors, inhibits, cell, cycle, angiogenesis, antifungals, hedgehog, Smoothened, Receptors, Antiangiogenics, Cell, Cycle, Inhibitors, Antibiotics, 5981, Tocris Bioscience
Citations for Itraconazole
Citations are publications that use Tocris products.
Currently there are no citations for Itraconazole. Do you know of a great paper that uses Itraconazole from Tocris? Please let us know.
Reviews for Itraconazole
There are currently no reviews for this product. Be the first to review Itraconazole and earn rewards!
Have you used Itraconazole?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.