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SMO antagonist (IC50 = 690 nM); acts at different binding site to cyclopamine (Cat. No. 1623). Also cytochrome p450 inhibitor (IC50 = 16-26 nM). Inhibits cell cycle at G1 phase in vitro and blocks angiogenesis in vivo (IC50 = 160 nM). Antifungal.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|DMSO||14.11||20 with gentle warming|
Preparing Stock Solutions
The following data is based on the product molecular weight 705.63. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.2 mM||7.09 mL||35.43 mL||70.86 mL|
|1 mM||1.42 mL||7.09 mL||14.17 mL|
|2 mM||0.71 mL||3.54 mL||7.09 mL|
|10 mM||0.14 mL||0.71 mL||1.42 mL|
References are publications that support the biological activity of the product.
Chong et al (2007) Inhibition of angiogenesis by the antifungal drug itracon. ACS Chem.Biol. 2 263 PMID: 17432820
Kim et al (2013) Itraconazole and arsenic trioxide inhibit Hedgehog pathway activation and tumor growth associated with acquired resistance to smoothened antagonists. Cancer Cell 23 23 PMID: 23291299
Kim et al (2010) Itraconazole, a commonly used antifungal that inhibits Hedgehog pathway activity and cancer growth. Cancer Cell 17 388 PMID: 20385363
Pace et al (2016) Repurposing the clinically efficacious antifungal agent itracon. as an anticancer chemotherapeutic. J.Med.Chem. 59 3635 PMID: 27014922
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Keywords: Itraconazole, Itraconazole supplier, SMO, antagonists, smoothened, receptors, cytochrome, p450, inhiibitors, inhibits, cell, cycle, angiogenesis, antifungals, hedgehog, Smoothened, Receptors, Antiangiogenics, Cell, Cycle, Inhibitors, Antifungals, 5981, Tocris Bioscience
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