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Biological Activity for Itraconazole
Itraconazole is a SMO antagonist (IC50 = 690 nM); acts at different binding site to cyclopamine (Cat. No. 1623). Also cytochrome p450 inhibitor (IC50 = 16-26 nM). Inhibits cell cycle at G1 phase in vitro and blocks angiogenesis in vivo (IC50 = 160 nM). Antifungal.
Technical Data for Itraconazole
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Itraconazole
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|DMSO||14.11||20 with gentle warming|
Preparing Stock Solutions for Itraconazole
The following data is based on the product molecular weight 705.63. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.2 mM||7.09 mL||35.43 mL||70.86 mL|
|1 mM||1.42 mL||7.09 mL||14.17 mL|
|2 mM||0.71 mL||3.54 mL||7.09 mL|
|10 mM||0.14 mL||0.71 mL||1.42 mL|
References for Itraconazole
References are publications that support the biological activity of the product.
Chong et al (2007) Inhibition of angiogenesis by the antifungal drug itracon. ACS Chem.Biol. 2 263 PMID: 17432820
Kim et al (2013) Itraconazole and arsenic trioxide inhibit Hedgehog pathway activation and tumor growth associated with acquired resistance to smoothened antagonists. Cancer Cell 23 23 PMID: 23291299
Kim et al (2010) Itraconazole, a commonly used antifungal that inhibits Hedgehog pathway activity and cancer growth. Cancer Cell 17 388 PMID: 20385363
Pace et al (2016) Repurposing the clinically efficacious antifungal agent itracon. as an anticancer chemotherapeutic. J.Med.Chem. 59 3635 PMID: 27014922
If you know of a relevant reference for Itraconazole, please let us know.
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Keywords: Itraconazole, Itraconazole supplier, SMO, antagonists, smoothened, receptors, cytochrome, p450, inhiibitors, inhibits, cell, cycle, angiogenesis, antifungals, hedgehog, Smoothened, Receptors, Antiangiogenics, Cell, Cycle, Inhibitors, Antifungals, 5981, Tocris Bioscience
2 Citations for Itraconazole
Citations are publications that use Tocris products. Selected citations for Itraconazole include:
Amit et al (2022) Nucleoli in epithelial cell collectives respond to tumorigenic, spatial, and mechanical cues. Mol Biol Cell 33 br19 PMID: 35830599
Jonathan S et al (2020) Optimized Vivid-derived Magnets photodimerizers for subcellular optogenetics in mammalian cells. Elife 9 PMID: 33174843
Do you know of a great paper that uses Itraconazole from Tocris? Please let us know.
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Literature in this Area
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